Results 61 to 70 of about 184,846 (305)

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Overexpression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy

, 2020
ObjectiveThe Vitamin D receptor (VDR) has been positively associated with skeletal muscle mass, function and regeneration. Mechanistic studies have focused upon loss of the receptor, with in vivo whole-body knockout models demonstrating reduced myofiber ...
Atherton, Philip J.,, Garcia, Amadeo Mu�oz, Szewczyk, Nathaniel J., Gallagher, Iain J.,, Smith, Ken,, Atherton, Philip J., Brook, Matthew S., Andersen, Ditte, Garcia, Amadeo Muñoz, Nakhuda, Asif,, Wilkinson, Daniel J., Cleasby, Mark E, Atherton, Philip J, Garcia, Amadeo Munoz,, Cleasby, Mark E., Andersen, Ditte,, Philp, Andrew,, Gallagher, Iain James, Brook, Matthew S.,, Deane, Colleen S.,, Kadi, Fawzi,, Gallagher, Iain J, Deane, Colleen S, Gallagher, Iain J., Wilkinson, Daniel J.,, Szewczyk, Nathaniel J.,, Cleasby, Mark E.,, Szewczyk, Nathaniel, Bass, Joseph J., Smith, Ken, Philp, Andrew, Bass, Joseph J.,, Tarum, Janelle, Brook, Mathew S., Szewczyk, Nathaniel J, Phillips, Bethan E.,, Deane, Colleen S., Wilkinson, Daniel J, Tarum, Janelle,, Phillips, Bethan E, Brook, Matthew S, Bass, Joseph J, Phillips, Bethan E., Kadi, Fawzi, Nakhuda, Asif   +44 more
core   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Vitamin D Receptor (VDR) Gene BsmI Polymorphisms in Lupus Nephritis

مجله دانشکده پزشکی اصفهان, 2011
Background: Vitamin D has immunomodulatory function. Polymorphisms of the gene encoding the vitamin D receptor detected by BsmI may be source of diversity in its action.
Mahnaz Abbasi, Zahra Rezaieyazdi, Jalil Tavakol afshari, Mohammadreza Hatef, Maryam Sahebari   +4 more
doaj  

Human Cytomegalovirus Induces Vitamin-D Resistance In Vitro by Dysregulating the Transcriptional Repressor Snail

Viruses, 2022
Vitamin-D supplementation is considered to play a beneficial role against multiple viruses due to its immune-regulating and direct antimicrobial effects.
Carmen Stecher, Katharina Philomena Maurer, Marie-Theres Kastner, Christoph Steininger   +3 more
doaj   +1 more source

Glucocorticoid regulation of the vitamin D receptor [PDF]

The Journal of Steroid Biochemistry and Molecular Biology, 2010
Many studies indicate calcitriol has potent anti-tumor activity in different types of cancers. However, high levels of vitamin D can produce hypercalcemia in some patients. Glucocorticoids are used to ameliorate hypercalcemia and to enhance calcitriol anti-tumor activity.
Alejandro A, Hidalgo, Donald L, Trump, Candace S, Johnson   +2 more
openaire   +2 more sources

Vitamin D supplementation and breast cancer prevention : a systematic review and meta-analysis of randomized clinical trials [PDF]

, 2013
In recent years, the scientific evidence linking vitamin D status or supplementation to breast cancer has grown notably. To investigate the role of vitamin D supplementation on breast cancer incidence, we conducted a systematic review and meta-analysis ...
Nancy Santesso (435397), Pizzuti, Laura, Pizzuti, L, Montella, Maurizio, Nancy Santesso, Santesso Nancy, Patrizia Vici (85361), Santesso, Nancy, Barba, Maddalena, Anna Crispo (435403), Mariani, Luciano, Barba M., Maugeri-Saccà, Marcello, Maddalena Barba, Montella Maurizio, Laura Pizzuti, Mottolese Marcella, Sergi D., Patrizia Vici, Domenico Sergi, Francesca Sperati, Stranges, Saverio, Luigi Di Lauro (435401), Vici Patrizia, Luciano Mariani (435398), Antonio Giordano, Barba Maddalena, Montella, M, Marcella Mottolese (85368), Sperati, Francesca, Francesca Sperati (95245), Mottolese M., Sperati Francesca, Saverio Stranges, Mariani L., Crispo, A, Di Lauro, L, Laura Pizzuti (435400), Pizzuti L., Saverio Stranges (73786), Marcella Mottolese, Giordano, A, Pizzuti Laura, Crispo A., Marcello Maugeri-Saccà, Barba, M, Maugeri-Saccà Marcello, Stranges, S, Santesso N., Di Lauro, Luigi, Stranges S., Maurizio Montella, Marcello Maugeri-Saccà (435396), Antonio Giordano (55096), Vici P., Sperati, F, Di Lauro Luigi, Sergi, D, Sergi, Domenico, Santesso, N, Mariani, L, Luigi Di Lauro, Giordano, Antonio, MD, Giordano A., Mottolese, M, Giordano, Antonio|, Stranges Saverio, Di Lauro L., Mottolese, Marcella, Maddalena Barba (82927), Sergi Domenico, Crispo Anna, Luciano Mariani, Maurizio Montella (435402), Sperati F., Giordano Antonio, Vici, P, Montella M., Crispo, Anna, Maugeri-Saccà, M, Vici, Patrizia, Mariani Luciano, Anna Crispo, Domenico Sergi (435399), Maugeri-Sacca M.   +84 more
core   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis [PDF]

, 2009
Antimicrobial peptides (AMPs) are strongly expressed in lesional skin in psoriasis and play an important role as proinflammatory "alarmins" in this chronic skin disease.
Koglin, Sarah, Ulrich Zügel, Thomas Ruzicka, Büchau Amanda, Dombrowski, Yvonne, Zügel, Ulrich, Steinmeyer, Andreas, Jürgen Schauber, Schauber, Jürgen, Büchau, Amanda, Sarah Koglin, Steinmeyer Andreas, Bradac, Eva, Mark Peric, Schauber Jürgen, Koglin Sarah, Amanda Büchau, Zügel Ulrich, Yvonne Dombrowski, Eva Bradac, Katrin Gross, Peric Mark, Gross, Katrin, Dombrowski Yvonne, Peric, Mark, Andreas Steinmeyer, Dombrowski, Yvonne; id_orcid, Bradac Eva, Groß Katrin, Ruzicka, Thomas, Ruzicka Thomas   +30 more
core   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

Arthritis Care &Research, EarlyView.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo, Robert Fox, Katherine M. Hammitt, Julie Frantsve‐Hawley, Matthew C. Baker, Stamatina Danielides, Eduardo De Sousa, Brent P. Goodman, Jennifer K. King, Steven Mandel, Ghaith Noaiseh, Pantelis P. Pavlakis, George Sarka, R. Hal Scofield, Arun Varadhachary, Daniel J. Wallace, Matt Makara, Nancy Carteron, Steven Carsons, in collaboration with the Consensus Expert Panel (CEP) members, G. Alden Adkins, Brittany Adler, Hossein Ansari, Senada Arabelovic, Alan Baer, Denis Balaban, Shamik Bhattacharyya, Evelyn Bromet, Krishna Chaganti, Kamal Chemali, Melissa Cortez, Schartess Culpepper, Paul Dellaripa, Dana Direnzo, Daniel El Bogdadi, Robert Fearon, Mehrnez Fischbach, Judi Furlong, Christopher Gibbons, Rachael Gordon, Thomas Grader Beck, Syed Haider, Larry Hollenbeck, Chadwick R. Johr, Stuart S. Kassan, Brian King, Octavia Kincaid, Eugene Kissin, Vasileios Kyttaris, Lindsay Lally, Brandon M. Law, Janet Lewis, Scott M. Lieberman, Amanda Lusa, Joseph Lutt, Rashmi Maganti, Arthur M. Mandelin, Sara McCoy, Kerry Neall, Timothy Niewold, Anne Louise Oaklander, Ruben A. Peredo‐Wende, Lynn Petruzzi, Mark A. Porter, Guada Respicio Duque, Tania Reyna, Nathaniel M. Robbins, Elliot D. Rosenstein, Laura Rosow, Breanna Ruthrauff, Amit Sachdev, Nora Sandorfi, Sarah Schafer, Elena Schiopu, Chokkalingam Siva, Daniel Small, Sara M. Stern, Lauren Stiles, Susan Stoddard, Jinny Tavee, Donald Thomas, Edward L. Treadwell, Nagagopal Venna, Steven Vernino, Frederick B. Vivino, Brittany Weber, Sepideh Yadollahi, Huiying Yu, Scott Zashin   +88 more
wiley   +1 more source