Results 41 to 50 of about 14,972,601 (255)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials. [PDF]

, 2012
Introduction: Vitamin D may affect multiple health outcomes. If so, an effect on mortality is to be expected. Using pooled data from randomized controlled trials, we performed individual patient data (IPD) and trial level meta-analyses to assess ...
Salovaara, K., Smith, H.E., Jackson, Rebecca D, Sanders, Kerrie M., Jacobs, ET, Rebecca D Jackson (16135031), Sanders, KM, Tahir Masud (804313), Jacobs, E.T., JoAnn E Manson (13567339), Robbins, John A., Salovaara, K, Haakon E Meyer (10282121), Rejnmark, Lars, Abrahamsen, Bo, Jackson, Rebecca D., Mosekilde, Leif, Brixen, K., Mosekilde, L., Robbins, JA, Cyrus Cooper (141250), Lars Rejnmark (3752971), Mosekilde, L, Elizabeth T Jacobs (16135028), Bo Abrahamsen (650396), Meyer, Haakon E., Jackson, RD, Alison Avenell (82040), Jacobs, Elizabeth T., Smith, Helen E, Abrahamsen, Bo; id_orcid, Brixen, K, Salovaara, Kari, Manson, Joann E, Torgerson, D., Robbins, J.A., Avenell, A, Robbins, John A, Francis, Roger M., Roger M Francis (7380278), Abrahamsen, B, Masud, T, Jacobs, Elizabeth T, Manson, JoAnn E., Anderson, F., Francis, R.M., Kerrie M Sanders (13488952), Francis, RM, David Torgerson (462403), Masud, T., Helen E Smith (16045475), Abrahamsen, B., Manson, J.E., Cooper, Cyrus, Sanders, K.M., Frazer Anderson (16135022), Meyer, Haakon E, Anderson, F, Torgerson, D, Kari Salovaara (16135025), Meyer, H.E., Rejnmark, L, Francis, Roger M, John A Robbins (8553495), Torgerson, David, Masud, Tahir, Smith, HE, Anderson, Frazer, Cooper, C., Meyer, HE, Kim Brixen (16135034), Jackson, R.D., Smith, Helen E., Cooper, C, Rejnmark, L., Manson, JE, Avenell, Alison, Avenell, A., Brixen, Kim, Leif Mosekilde (349340), Sanders, Kerrie M   +80 more
core   +1 more source

Overexpression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy [PDF]

, 2020
ObjectiveThe Vitamin D receptor (VDR) has been positively associated with skeletal muscle mass, function and regeneration. Mechanistic studies have focused upon loss of the receptor, with in vivo whole-body knockout models demonstrating reduced myofiber ...
Atherton, Philip J.,, Garcia, Amadeo Mu�oz, Szewczyk, Nathaniel J., Gallagher, Iain J.,, Smith, Ken,, Atherton, Philip J., Brook, Matthew S., Andersen, Ditte, Garcia, Amadeo Muñoz, Nakhuda, Asif,, Wilkinson, Daniel J., Cleasby, Mark E, Atherton, Philip J, Garcia, Amadeo Munoz,, Cleasby, Mark E., Andersen, Ditte,, Philp, Andrew,, Gallagher, Iain James, Brook, Matthew S.,, Deane, Colleen S.,, Kadi, Fawzi,, Gallagher, Iain J, Deane, Colleen S, Gallagher, Iain J., Wilkinson, Daniel J.,, Szewczyk, Nathaniel J.,, Cleasby, Mark E.,, Szewczyk, Nathaniel, Bass, Joseph J., Smith, Ken, Philp, Andrew, Bass, Joseph J.,, Tarum, Janelle, Brook, Mathew S., Szewczyk, Nathaniel J, Phillips, Bethan E.,, Deane, Colleen S., Wilkinson, Daniel J, Tarum, Janelle,, Phillips, Bethan E, Brook, Matthew S, Bass, Joseph J, Phillips, Bethan E., Kadi, Fawzi, Nakhuda, Asif   +44 more
core   +1 more source

The vitamin D receptor agonist EB1089 can exert its antiviral activity independently of the vitamin D receptor.

PLoS ONE, 2023
Vitamin D has been shown to have antiviral activity in a number of different systems. However, few studies have investigated whether the antiviral activity is exerted through the vitamin D receptor (VDR).
Janejira Jaratsittisin, Wannapa Sornjai, Thanathom Chailangkarn, Anan Jongkaewwattana, Duncan R Smith   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin d in mice fed a high-fat diet [PDF]

, 2014
The role of vitamin D in curtailing the development of obesity and comorbidities such as the metabolic syndrome (MetS) and type 2 diabetes has received much attention recently. However, clinical trials have failed to conclusively demonstrate the benefits
Feelisch, Martin, Weller, Richard B; id_orcid, Matthews, Vance, Jacoby, Peter, Endersby, Raelene, Hart, Prue H, Geldenhuys, Sian, Weller, Richard B., Hart, Prue H., Gorman, Shelley   +9 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Hospital admissions for vitamin D related conditions and subsequent immune-mediated disease: record-linkage studies. [PDF]

, 2013
BACKGROUND: Previous studies have suggested that there may be an association between vitamin D deficiency and the risk of developing immune-mediated diseases.
Giulio Disanto, Michael J Goldacre, Goldacre, R, Sreeram V Ramagopalan, Gavin Giovannoni, Raph Goldacre, Ramagopalan, SV, Goldacre, MJ, Goldacre, Michael, Giovannoni, G, Disanto, G   +10 more
core   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The Assessment of Vitamin D, Antimicrobial Peptides and Procalcitonin in Bronchiectasis [PDF]

, 2014
My research investigated the distribution of antimicrobial peptides (cathelicidin and β-defensin 2), vitamin D and the inflammatory marker procalcitonin, between systemic and localised respiratory levels in stable bronchiectasis patients.
Gartner, Sarah Nicole
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