Results 71 to 80 of about 569,165 (382)

Timing and Predictive Value of Clinical Conditions Preceding Multiple Sclerosis in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Multiple sclerosis (MS) patients often experience a higher incidence of clinical conditions before diagnosis, suggesting a prodromal phase. However, their predictive value and temporal trajectories remain underexplored. We investigated these aspects using the large UK Biobank's population‐based cohort, which provided clinical ...
Andrea Nova, Teresa Fazia, Giovanni Di Caprio, Davide Gentilini, Luisa Bernardinelli, Roberto Bergamaschi   +5 more
wiley   +1 more source

Maximizing the benefits and minimizing the risks of intervention programs to address micronutrient malnutrition: symposium report. [PDF]

, 2016
Interventions to address micronutrient deficiencies have large potential to reduce the related disease and economic burden. However, the potential risks of excessive micronutrient intakes are often not well determined.
Bruins, Maaike J, Engle-Stone, Reina, Kraemer, Klaus, Kupka, Roland, Lietz, Georg, Zimmermann, Michael B   +5 more
core   +1 more source

Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio).

Journal of NutriLife, 2011
α-Tocopherol is a required, lipid-soluble antioxidant that protects PUFA. We hypothesized that α-tocopherol deficiency in zebrafish compromises PUFA status.
K. Lebold, D. Jump, Galen W. Miller, Charlotte L. Wright, Edwin M. Labut, Carrie L. Barton, Robert L. Tanguay, M. Traber   +7 more
semanticscholar   +1 more source

Cognitive Resilience in Apolipoprotein ε4 Carrier Women Predicted by Neuron‐Derived Extracellular Vesicles

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Apolipoprotein (APOE) ε4 allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD); however, many ε4 carriers remain cognitively intact into old age. Leveraging plasma neuron‐derived extracellular vesicles (NDEVs), we sought to identify biomarkers of cognitive resilience and their interplay with APOE ...
Apostolos Manolopoulos, Maja Mustapic, Carlos Nogueras‐Ortiz, Francheska Delgado‐Peraza, Krishna A. Pucha, Pamela J. Yao, Joseph Blommer, Michael P. Vreones, William York, De' Larrian Knight, Stephen R. Rapp, Aladdin H. Shadyab, JoAnn E. Manson, Ramon Casanova, Robert B. Wallace, Luigi Ferrucci, Susan M. Resnick, Dimitrios Kapogiannis   +17 more
wiley   +1 more source

Using a Supramolecular Approach to Engineer Modular Hydrogel Platforms for Culturing Protoplasts – from General Tissue Engineering to Cellular Agriculture

Advanced Biology, EarlyView.
Using supramolecular monomers, various hydrogel culture systems were formulated to culture protoplasts; including 2D, 2.5D, and 3D hydrogels. Depending on the culture platform, bioactive functionalization led to protoplast enlargement (2D and 2.5D) or plasmolysis (3D). This work shows the potential to modularly engineer synthetic platforms for cellular
Maritza M. Rovers, Erik J. Slootweg, Ferdinand C. O. Los, Patricia Y. W. Dankers   +3 more
wiley   +1 more source

The effect of vitamin E deficiency on some platelet membrane properties.

Journal of Lipid Research, 1982
The effects of alpha-tocopherol (vitamin E) deficiency on membrane properties of platelets were studied to determine if vitamin E has a measureable stabilizing role in biological membranes.
J C Whitin, R K Gordon, L M Corwin, E R Simons   +3 more
doaj  

Sensory Ataxia and Vitamin E Deficiency

Pediatric Neurology Briefs, 1994
A progressive limb and gait ataxia, distal loss of proprioception and vibration sense, and areflexia, caused by a prolonged and severe vitamin E deficiency, are reported in four patients evaluated as adults at King’s College, Hammersmith Hospital, and ...
J Gordon Millichap
doaj   +1 more source

Prevalence of vitamin D deficiency among healthy adolescents.

Archives of Pediatrics & Adolescent Medicine, 2004
BACKGROUND Although vitamin D deficiency has been documented as a frequent problem in studies of young adults, elderly persons, and children in other countries, there are limited data on the prevalence of this nutritional deficiency among healthy US ...
Catherine M. Gordon, Kerrin C DePeter, Henry A. Feldman, E. Grace, S. Emans   +4 more
semanticscholar   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Vitamin E requirements of adult domestic cats (Felis catus) fed diets containing high levels of fish oil : a thesis presented in partial fulfilment of the requirement for the degree of Master of Nutritional Sciences at Massey University, Palmerston North, New Zealand [PDF]

, 1999
The vitamin E (α-tocopherol) requirement of adult cats fed diets containing high levels of fish oil was investigated. Thirty-two (16 male, 16 female) adult domestic cats (Felis catus) were randomly allocated to four groups according to sex and fed one of
Wu, Yuben
core