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Pros and Cons of Vitamin K Antagonists and Non–Vitamin K Antagonist Oral Anticoagulants
Seminars in Thrombosis and Hemostasis, 2015 Anticoagulant treatment can be currently instituted with two different classes of drugs: the vitamin K antagonists (VKAs) and the newer, "novel" or non-vitamin K antagonist oral anticoagulant drugs (NOACs).
Walter Ageno, Nicoletta Riva
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Hämostaseologie, 2012
SummaryFor the last decades, anticoagulation for stroke prevention in atrial fibrillation (AF) as well as for the prophylaxis and long-term treatment of venous thromboembolism has been entirely based on vitamin K antagonists (VKA). Although very effective under optimal conditions, long-term treatment with these drugs is flawed by the fact that the time
Steffel J, Luscher TF
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SummaryFor the last decades, anticoagulation for stroke prevention in atrial fibrillation (AF) as well as for the prophylaxis and long-term treatment of venous thromboembolism has been entirely based on vitamin K antagonists (VKA). Although very effective under optimal conditions, long-term treatment with these drugs is flawed by the fact that the time
Steffel J, Luscher TF
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Lancet, The, 2008 BACKGROUND: Vitamin K antagonists, the current standard treatment for prophylaxis against stroke and systemic embolism in patients with atrial fibrillation, require regular monitoring and dose adjustment; an unmonitored, fixed-dose anticoagulant regimen ...
Graeme J. Hankey +2 more
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A COMPREHENSIVE REVIEW OF VITAMIN K AND VITAMIN K ANTAGONISTS
Hematology/Oncology Clinics of North America, 2000For more than 60 years, vitamin K-dependent proteins have been known to play an important role in regulating blood coagulation. During recent years it has become clear, however, that vitamin K is also involved in other physiologic processes, including bone metabolism and vascular biology.
C, Vermeer, L J, Schurgers
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2023
Abstract Since the 1950s, vitamin K antagonists have been used for the prevention and treatment of venous and arterial thrombotic disorders. They have a narrow therapeutic window. To ensure efficacy and safety, close monitoring of the anticoagulation status is mandatory. Dietary and drug interactions are common.
Freek W.A. Verheugt, Marc A. Brouwer
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Abstract Since the 1950s, vitamin K antagonists have been used for the prevention and treatment of venous and arterial thrombotic disorders. They have a narrow therapeutic window. To ensure efficacy and safety, close monitoring of the anticoagulation status is mandatory. Dietary and drug interactions are common.
Freek W.A. Verheugt, Marc A. Brouwer
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Vitamin K antagonists and emergencies
European Journal of Emergency Medicine, 2018The recent emergence of ‘non-VKA’ oral anticoagulants may have led to some forgetting that vitamin K antagonists (VKA) are by far the most widely prescribed oral anticoagulants worldwide. Consequently, we decided to summarize the information available on them. This paper presents the problems facing emergency physicians confronted with patients on VKAs
Lapostolle, Frédéric +6 more
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The Role of Dietary Vitamin K in the Management of Oral Vitamin K Antagonists
Blood Reviews, 2012Vitamin K antagonists (VKA) have been the mainstay of oral anticoagulant therapy for over 60years. In this review we critically assess the evidence for the importance of vitamin K nutrition during VKA therapy; the methodologies for measuring dietary intakes; the vitamin K intake data in patients on VKA and healthy people; and the experimental evidence ...
Michael V Holmes
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Vitamin K and Vitamin K Antagonists
2020Vitamin Κ was discovered by Henrik Dam in 1929 in studies of sterol metabolism in chicks fed fat-free diets (1). The antihemorrhagic fat-soluble agent was called vitamin Κ, Κ being short for "Koagulation" (the German word for coagulation). Since then there have been two major eras of extensive research on this vitamin.
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