Results 251 to 260 of about 10,028,727 (294)
Some of the next articles are maybe not open access.
Vitamin K Antagonists: Beyond Bleeding
Seminars in Dialysis, 2014AbstractWarfarin is the most widely used oral anticoagulant in clinical use today. Indications range from prosthetic valve replacement to recurrent thromboembolic events due to antiphospholipid syndrome. In hemodialysis (HD) patients, warfarin use is even more frequent than in the nonrenal population due to increased cardiovascular comorbidities.
Thilo, Krüger, Jürgen, Floege
openaire +2 more sources
Management of vitamin K antagonists in the elderly
Annales de biologie clinique, 2014Elderly patients of 80 years and above are commonly frail, due to substantial comorbid conditions and numerous medications. Managing elderly patients receiving vitamin K antagonists (VKA) is challenging because those patients are at high risk of both thrombosis and bleeding.
Tiphaine, Belleville +3 more
openaire +2 more sources
1966
Publisher Summary Vitamin K activity is shared by a fairly large number of compounds. They consist, in the main, of two naturally occurring groups of compounds: phylloquinones (K), containing saturated isoprenoid side chains, and menaquinones (MK) with unsaturated isoprenoid side chains.
openaire +3 more sources
Publisher Summary Vitamin K activity is shared by a fairly large number of compounds. They consist, in the main, of two naturally occurring groups of compounds: phylloquinones (K), containing saturated isoprenoid side chains, and menaquinones (MK) with unsaturated isoprenoid side chains.
openaire +3 more sources
Oral anticoagulation with vitamin K-antagonists
Therapeutische Umschau, 2003Coumarin-Derivate finden heute eine breite klinische Anwendung und sollten deswegen zur Gruppe der «vertrauten» Medikamente gehören. In der vorliegenden Übersichtsarbeit werden verschiedene Aspekte der Behandlung mit Vitamin K-Antagonisten beleuchtet: die Bedeutung von Vitamin K für die Synthese von funktionsfähigen Gerinnungsfaktoren, klinisch ...
openaire +2 more sources
THE ANTAGONISTIC EFFECT OF VITAMIN A ON VITAMIN K IN THE GERMFREE RAT
Nutrition Reviews, 1966Survival time of the germfree rat on a diet deficient in vitamin K is not affected by physiological doses of vitamin A. However, excess doses of vitamin A may result in systemic antagonism to vitamin K.
openaire +2 more sources
The vitamin K antagonists and their limitations
2010The vitamin K antagonists (VKAs) have been the mainstay of oral anticoagulant therapy for more than 50 years, warfarin being the VKA most commonly used worldwide. The longstanding popularity of the VKAs is largely based on their effectiveness in the prevention and treatment of venous thromboembolism (VTE), as well as the prevention of systemic embolism
Chee W Khoo, Gregory Y H Lip
openaire +1 more source
Vitamin K Antagonists – Current Concepts and Challenges
Thrombosis Research, 2011Vitamin K antagtonists (VKAs) have, for decades, been the corner-stone of anticoagulation in the outpatient setting. While the long half life makes once daily administration practical, close monitoring of VKA effect is necessary because these medicines have a narrow therapeutic index.
Hayan, Moualla, David, Garcia
openaire +2 more sources
Cancer prevention and vitamin K antagonists: An overview
Thrombosis Research, 2010The relation of cancer to thromboembolism has been described since the mid 1800s. Different studies in animal and in vitro models have confirmed the link between the haemostatic system and both tumor stroma formation and metastasis. Although the mechanisms of warfarin effects on cancer are not elucidated, but are based on hypothesis, various studies ...
PENGO, VITTORIO +3 more
openaire +3 more sources
[Vitamin K antagonists overdose].
Przeglad lekarski, 2016Nowadays, anticoagulant therapy belongs to the most commonly used forms of pharmacotherapy in modern medicine. The most important representatives of anticoagulants are heparins (unfractionated heparin and low-molecular-weight heparin) and coumarin derivatives (vitamin K antagonists--VKA).
Barbara, Groszek, Paweł, Piszczek
openaire +1 more source
Bleeding risks associated with vitamin K antagonists
Blood Reviews, 2013Vitamin K antagonists are widely used for the prevention of stroke due to atrial fibrillation, treatment and secondary prevention of venous thromboembolism, prevention of valvular thromboembolism in patients with prosthetic heart valves, and secondary prevention of acute myocardial infarction.
openaire +2 more sources