Results 281 to 290 of about 818,499 (336)

NQO1/p65/CXCL12 Axis‐Recruited Tregs Mediate Resistance to Anti‐PD‐1 Plus Lenvatinib Therapy in PIVKA‐II‐Positive Hepatocellular Carcinoma

Advanced Science, EarlyView.
High PIVKA‐II expression in HCC correlates with resistance to anti‐PD‐1 plus lenvatinib, driven by an immunosuppressive TME. NQO1/p65/CXCL12 axis recruits Tregs to promote resistance to anti‐PD‐1 plus lenvatinib in HCC with high PIVKA‐II expression.
Biao Gao, Yafei Wang, Zhuoya Sun, Haowen Tang, Yinbiao Cao, Hao Jiang, Wenwen Zhang, Yinzhe Xu, Bingyang Hu, Zhe Liu, Guankun Mao, Xuerui Li, Junfeng Li, Tao Wan, Bing Liu, Xiao Zhao, Shunchang Jiao, Chonghui Li, Shichun Lu   +18 more
wiley   +1 more source

Vitamins, Vascular Health and Disease. [PDF]

Nutrients
Ayoub G.
europepmc   +1 more source

Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Group‐specific component protein (GC) promotes perineural invasion (PNI) in pancreatic ductal adenocarcinoma (PDAC) by activating Schwann cell dedifferentiation and by enhancing tumor–Schwann cell chemoattraction, independently of vitamin D transport. Integrin β1 (ITGB1) functions as a GC receptor in both cancer cells and Schwann cells.
Shan Zhang, Luju Jiang, Shuqi Cai, Zheqi Weng, Yuheng Zhu, Zhi‐Wei Cai, Hui Li, Qing Li, Li‐Peng Hu, Hong‐Fei Yao, Rong Hua, Yu Zhao, Dongxue Li, Xiao‐Mei Yang, Jun‐Feng Zhang, Shu‐Heng Jiang   +15 more
wiley   +1 more source

National Guide on Nutrition Care and Support for People Living With HIV/AIDS\ud [PDF]

, 2003
Abdallah., Fatma, Charles, Tumaini, Elisaria,, Esther, Kimboka, Sabas, Kyungu, Lunna, Lorri, Wilbard, Lyatuu, Vumilia, Macha, Elizabeth, Magambo, Faith, Mboya, Pantaleo, Missano, Hilda, Ndossi, Godwin, Ngonyani, Monica, Nnally, Luitfrid, Ntoga, Bupe, Nyagawa, Daniel, Rwenyagira, Margeth, Sanga, Alfred, Semu, Hellen, Shirima, Restituta, Urio, Elisante   +20 more
core  

Unveiling the mechanistic nexus: how micronutrient enrichment shapes brain function, and cognitive health. [PDF]

Front Mol Biosci
Das S, Banerjee P, Jana S, Mondal H.
europepmc   +1 more source

Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection

Advanced Science, EarlyView.
Punicalagin, a pomegranate molecule, helps the body fight Mycobacterium abscessus. It preferentially boosts interstitial macrophages in the lung, stabilizing mitochondria and switching on the autophagy via SIRT1/FoxO3a, which lowers bacterial load without directly killing bacteria.
Kefan Bi, Bihan Xu, Dan Cao, Kaijin Xu, Ying Zhang   +4 more
wiley   +1 more source

Disease Diagnosis Using Retinal Vasculature: Insights from Flammer Syndrome and AI. [PDF]

Brain Sci
Ayoub G.
europepmc   +1 more source

Enhanced Selenium Supplement Extends Lifespan and Delays Multi‐Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis

Advanced Science, EarlyView.
Aging involves physiological decline and heightened disease susceptibility, necessitating effective interventions. Redox‐responsive selenium‐loaded nanoparticles (SeMSNs) are developed, which delay cellular senescence by reducing oxidative stress and senescence markers (p16/p21). In aged mice, SeMSNs extend lifespan, improve organ function, and restore
Yang Yu, Jintao Song, Mengjiao Guo, RuZe Ma, Mingyang Du, Zhe Xun, Xu Liu, RongXia Xu, Xiaochun Xie, Peilin Qi, Yujie Chen, Dan Shao, Chao Yang, Liang Wang, Xiaoyu Song, Difei Wang   +15 more
wiley   +1 more source

The role of fat-soluble vitamins on bone metabolism and osteoporosis: a literature review. [PDF]

Ann Med
Li H, Cao W, Tao L, Zhu Y.
europepmc   +1 more source

Bimetallic Nanozyme Amplifier for Synergistic Ferroptosis‐Cuproptosis and Metabolic Reprogramming to Reshape Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
The Bimetallic Nanozyme Amplifier (PEG@AuCZ@CC) to maximize hydrogen peroxide production and reprogram tumor metabolism from glycolysis to oxidative phosphorylation. This shift enhances ferroptotic/cuproptotic signaling cascades and creates a glucose‐enriched but lactate‐depleted tumor microenvironment (TME), effectively overcoming immune tolerance in ...
Jianzhang Luo, Kunzhao Huang, Xiaoyuan Yi, Pei Lu, Huaying Xie, Wen Li, Qingyu Zeng, Feifei He, Duo Wang, Liyan Wang   +9 more
wiley   +1 more source