Results 61 to 70 of about 68,175 (264)

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Assessment of the feed additive consisting of calcium D‐pantothenate for all animal species for the renewal of its authorisation (BASF SE)

EFSA Journal
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of calcium D‐pantothenate for the renewal of its authorisation as a nutritional feed additive for all animal species. The additive
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Roberto Edoardo Villa, Ruud Woutersen, Jaume Galobart, Orsolya Holczknecht, Fabiola Pizzo, Maria Vittoria Vettori, Anita Radovnikovic   +21 more
doaj   +1 more source

The Importance of Micronutrient Adequacy in Obesity and the Potential of Microbiota Interventions to Support It

Applied Sciences
Micronutrient deficiencies co-occur with obesity throughout the world. While many factors may contribute to this, microbiota dysbiosis is certainly one that has received a lot of attention in recent years.
Agnieszka Rudzka, Kamila Kapusniak, Dorota Zielińska, Danuta Kołożyn-Krajewska, Janusz Kapusniak, Renata Barczyńska-Felusiak   +5 more
doaj   +1 more source

A 17 Year Old With Developmental Delay Presenting With Increasing Confusion and Imbalance

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Methylmalonic acidemia is an autosomal recessive genetic disorder primarily caused by defects in methylmalonyl‐CoA mutase and cobalamin (vitamin B12) metabolism. These defects disrupt the tricarboxylic acid cycle and oxidative phosphorylation, leading to the abnormal accumulation of metabolic products such as methylmalonic acid, propionic acid,
Wei Zhao, Yingli Zhang, Hongliang Zheng
wiley   +1 more source

Genetic diversity among yellow maize with pro-vitamin A content

Journal of Agriculture and Environment for International Development, 2016
An improvement in the concentration of vitamin A in adapted yellow maize varieties grown in Africa can have a positive impact on the dietary intakes in regions where maize is a staple food. The present study was designed to identify heterotic groups and divergent parents for developing new pro-vitamin A enriched maize lines. Ten Simple Sequence Repeats
Olowolafe, Mercy Oluremi, Kehinde, Moyib Oluwasayo, Tayo, Akinyosoye Solomon   +2 more
openaire   +2 more sources

The role of vitamin A and its pro-vitamin carotenoids in fetal and neonatal programming: gaps in knowledge and metabolic pathways

Nutrition Reviews, 2020
AbstractVitamin A (VA) and its pro-vitamin carotenoids are naturally occurring lipophilic compounds involved in several cellular processes and metabolic pathways. Despite their broad spectrum of activities in the general population, dietary deficiencies of these compounds can potentially affect pregnancy outcomes.
Leonardo M de Souza Mesquita, Laís V Mennitti, Veridiana V de Rosso, Luciana P Pisani   +3 more
openaire   +2 more sources

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Pro‐Vitamin A Biofortified Cavendish Banana: Trait Stability in the Field

Plant Biotechnology Journal
ABSTRACT Vitamin A deficiency (VAD), a major global health concern, has driven efforts to develop staple crops with enhanced pro‐vitamin A (pVA) content. Delivering meaningful nutritional benefits, however, requires technologies that maintain elevated carotenoid levels under field conditions.
Jimmy M. Tindamanyire, Jacinta L. Watkins, Cara Mortimer, Bulukani Mlalazi, Jeff Daniells, Rob Harding, James L. Dale, Jean‐Yves Paul   +7 more
openaire   +2 more sources

Farmers’ Willingness to Cultivate Pro-vitamin-A Cassava Variety in Kwara State, Nigeria

Journal of Agricultural Extension, 2020
The study examined factors underlying farmers’ perception about pro-vitamin-A cassava varieties and their willingness to cultivate them in Kwara State, Nigeria. One hundred and twenty-two (122) cassava farmers, selected through a multistage sampling procedure, were used for the study.
Olayinka Jelili Yusuf, Olatunji Yusuf Ambali, Ololade Latifat Abdulrahman, Oluwafemi Oluwatosin Lawal, Ibrahim Folorunsho Ayanda   +4 more
openaire   +4 more sources