Results 41 to 50 of about 32,153 (233)

Meta-Analysis of Alterations in Regulatory T Cells’ Frequency and Suppressive Capacity in Patients with Vitiligo

Journal of Immunology Research, 2022
Vitiligo is a noncontagious autoimmune skin depigmenting disease. Regulatory T cells (Tregs) play a key role in maintaining peripheral tolerance; however, Tregs’ number, suppressive function, and associated suppressive molecules (FOXP3, IL-10, and TGF-β)
Prashant S. Giri, Jahanvi Mistry, Mitesh Dwivedi   +2 more
doaj   +1 more source

Comprehensive Safety Exposure‐Response Analysis to Support Ritlecitinib Dose Selection

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Ritlecitinib is a kinase inhibitor drug recently approved for the treatment of alopecia areata (AA) in both adults and adolescents based on a single, combined Phase 2b/3 study. Various QD doses with and without a loading dose have been evaluated in the pivotal Phase 2b/3 study.
Yeamin Huh, Ruolun Qiu, John Prybylski, Jessica Wojciechowski, Yuchen Wang, Vivek S. Purohit   +5 more
wiley   +1 more source

Survivorship Needs and Experiences of Survivors of Head and Neck Cancer in Rural Australia: A Qualitative Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Semi‐structured interviews with 17 rural head and neck cancer survivors revealed six main themes relating to their survivorship needs and experiences: 1) financial impacts, 2) physical effects, 3) psychosocial effects, 4) clinical management, 5) information and support needs, and 6) access.
Poorva Pradhan, Helen Hughes, Ashleigh R. Sharman, Judith Lacey, Patrick Dwyer, Jacques Hill, Kimberley J. Davis, Steven Craig, Raymond Wu, Bruce Ashford, Jenny Mitchell, Jonathan R. Clark, Michael Elliott, Carsten E. Palme, Rebecca L. Venchiarutti   +14 more
wiley   +1 more source

Clinico-epidemiological profile of vitiligo patients in Najran Region, Saudi Arabia

Journal of Dermatology and Dermatologic Surgery, 2015
Objectives: To assess the prevalence of vitiligo among patients with dermatological diseases in Najran, South-Western Saudi Arabia, and to explore the epidemiological profile of vitiligo patients in the region. Materials and methods: This single-observer,
Hamad Ayed AL Fahaad
doaj   +1 more source

Development of consensus recommendations on the management of vitiligo and the role of decapeptide in vitiligo by the delphi method

Indian Journal of Dermatology, 2023
Background: Treatment of vitiligo is still a challenge in dermatology. Literature is sparse on the definitive clinical role of basic fibroblast growth factor (bFGF) in vitiligo patients.
Davinder Parsad, Sanjeev Kandhari, Rachita Dhurat, Bela Shah, Imran Majid, Harikishan Kumar Yadalla, Jagdish Sakhiya, Shital Poojary, P Jagadish, Pravin D Banotkar, Ravindra Babu, Y M Shivakumar, S K Bose, Saleem Jamadar, Monal Shah, Bharat Tank, Ravindra Dhabhai, Sanjay Kumar Mittal, Premanshu Bhushan, Akshi Pandita, Vaibhav Barve   +20 more
doaj   +1 more source

A Guide to Screening for Autoimmune Diseases in Patients With Vulvar Lichen Sclerosus

Australasian Journal of Dermatology, Volume 66, Issue 3, Page 135-141, May 2025.
ABSTRACT Background The aetiology of vulvar lichen sclerosus (VLS) remains unknown. However, there is evidence that in addition to a genetic predisposition, autoimmunity contributes to the pathogenesis. Objectives The objective of this study was to determine the prevalence of autoimmune disease and positive autoantibody serology in patients with VLS ...
Annabel Guttentag, Marlene Wijaya, Gayle O. Fischer, Angela Lee, Ken Liu, Rebecca Bronwyn Saunderson   +5 more
wiley   +1 more source

MicroRNA-146a and Forkhead box protein 3 expressions in nonsegmental vitiligo: an insight into disease pathogenesis

Journal of the Egyptian Women’s Dermatologic Society, 2019
Background Autoimmune destruction of melanocytes is the principal hypothesis in vitiligo pathogenesis. MicroRNA-146a (miRNA-146a) is considered an essential regulator of posttranscriptional gene expression, suggesting a potential role in autoimmune ...
Arwa M Hassan, Yomna M. El-Hamd Neinaa, Amal S El-Bendary, Soha S Zakaria   +3 more
doaj   +1 more source

The Genetics of Vitiligo [PDF]

Journal of Investigative Dermatology, 2011
Vitiligo is one of the most striking of all human disease phenotypes, and it is perhaps the most common pigmentary disorder. The patchy loss of skin pigmentation and the marked contrast between involved and uninvolved skin particularly impacts persons of color, with consequent stigmatization that has long been recognized to result in significant social
openaire   +3 more sources

Familial Frontal Fibrosing Alopecia Occurs Early in Daughters With Affected Mothers: A Case Report and a Review of the Literature

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Frontal fibrosing alopecia (FFA) is a form of cicatricial alopecia that is being increasingly diagnosed in recent years. It predominantly affects post‐menopausal women of various ethnic backgrounds, but cases have also been reported in pre‐menopausal women and rarely in men.
Adrienne Oxenham, Annabel Stevenson
wiley   +1 more source

New oral and topical approaches for the treatment of melasma

International Journal of Women's Dermatology, 2019
Melasma is a common, therapeutically challenging, and universally relapsing disorder of hyperpigmentation that is most often observed in women and individuals with Fitzpatrick Skin Types III through VI. The pathogenesis of melasma is complex and protean.
P.E. Grimes, MD, S. Ijaz, BA, MPH, R. Nashawati, BS, MSGM, D. Kwak   +3 more
doaj