Results 61 to 70 of about 389,924 (238)

The effect of a preoperative subconjuntival injection of dexamethasone on blood-retinal barrier breakdown following scleral buckling retinal detachment surgery: a prospective randomized placebo-controlled double blind clinical trial [PDF]

, 2010
Background: Blood-retinal barrier breakdown secondary to retinal detachment and retinal detachment repair is a factor in the pathogenesis of proliferative vitreoretinopathy (PVR). We wished to investigate whether an estimated 700 to 1000 ng/ml subretinal
Bali, E. (Ernesto), Feron, E.J. (Eric), Meurs, J.C. (Jan) van, Mulder, P.G.H. (Paul), Peperkamp, E. (Ed), Veckeneer, M.A.H. (Marc)   +5 more
core   +3 more sources

Techniques for subretinal injections in animals

Veterinary Ophthalmology, Volume 28, Issue 2, Page 506-518, March 2025.
Abstract Subretinal injections are not commonly performed during clinical treatment of animals but are frequently used in laboratory animal models to assess therapeutic efficacy and safety of gene and cell therapy products. Veterinary ophthalmologists are often employed to perform the injections in the laboratory animal setting, due to knowledge of ...
Ryan F. Boyd, Simon M. Petersen‐Jones
wiley   +1 more source

Clinicopathologic Correlation of a Subretinal Proliferative Vitreoretinopathy Band in a Patient with Chronic Recurrent Retinal Detachment

Case Reports in Ophthalmology, 2018
Purpose: Proliferative vitreoretinopathy is a well-known cause of failure of retinal detachment surgery. The purpose of this case report is to illustrate the clinical occurrence and histopathology of a horizontal subretinal band (“clothesline ...
Karen R. Brown, Sander R. Dubovy, Nidhi Relhan, Harry W. Flynn Jr.   +3 more
doaj   +1 more source

Increased Glial Fibrillary Acid Protein and Vimentin in Vitreous Fluid as a Biomarker for Proliferative Vitreoretinopathy

Investigative Ophthalmology and Visual Science, 2020
Purpose Glial fibrillary acid protein (GFAP) and vimentin are type III intermediate filament proteins, ubiquitously expressed in retinal glial cells.
S. Lee, John W. Surbeck, M. Drake, Apryl S Saunders, H. Jin, V. Shah, R. V. Rajala   +6 more
semanticscholar   +1 more source

Ozurdex(R) (a slow-release dexamethasone implant) in proliferative vitreoretinopathy: study protocol for a randomised controlled trial [PDF]

, 2013
Proliferative vitreoretinopathy (PVR) is the commonest cause of late anatomical failure in rhegmatogenous retinal detachment. Visual and anatomical outcomes remain poor despite advances in vitreoretinal surgical techniques with reported primary failure ...
Banerjee, PJ, Bunce, C, Charteris, DG
core  

Interventions for submacular haemorrhage: A systematic review and network meta‐analysis of controversies—On behalf of the Spanish Vitreo‐Retinal Society (SERV)

Acta Ophthalmologica, Volume 104, Issue 2, Page 139-163, March 2026.
Abstract Purpose This systematic review aims to evaluate and synthesize the existing literature on the interventions used for submacular haemorrhage (SMH), highlighting the controversies and differences in clinical practice. Method A systematic review was conducted following the PRISMA guidelines.
Salvador Pastor‐Idoate, Pablo Redruello‐Guerrero, Laura de Juan Hernández, Gregorio Benites‐Narcizo, Mario Rivera‐Izquierdo, José García‐Arumí, José Carlos Pastor Jimeno   +6 more
wiley   +1 more source

Topical delivery of a small molecule RUNX1 transcription factor inhibitor for the treatment of proliferative vitreoretinopathy

Scientific Reports, 2020
Proliferative vitreoretinopathy (PVR) is the leading cause of retinal detachment surgery failure. Despite significant advances in vitreoretinal surgery, it still remains without an effective prophylactic or therapeutic medical treatment.
Santiago Delgado-Tirado, Dhanesh Amarnani, Guannan Zhao, E. Rossin, D. Eliott, John B. Miller, Whitney A. Greene, Leslie Ramos, Said Arévalo-Alquichire, David Leyton-Cifuentes, L. González-Buendía, Daniela Isaacs-Bernal, Hannah A. B. Whitmore, N. Chmielewska, Brandon V. Duffy, Eric J. Kim, H. Wang, J. Ruiz-Moreno, L. Kim, Joseph F. Arboleda-Velasquez   +19 more
semanticscholar   +1 more source

Methotrexate‐Loaded Liposomal Formulation Enables 6‐Week Sustained Intraocular Therapeutic Drug Release in a Porcine Model

Advanced Healthcare Materials, Volume 15, Issue 1, 9 January 2026.
A liposomal formulation for methotrexate enables minimally invasive, sustained intraocular drug delivery for over six weeks with a single injection. Developed for treating intraocular diseases like lymphoma and PVR, it offers excellent biocompatibility in vivo in a porcine model.
Maximilian Hammer, Lea Skrzypczyk, Sabrina Wohlfart, Bryan Calder Ackermann, Ludwig Geisweid, Simon William Pohl, Margarita Karaivanova, Jonathan Herth, Victor Aristide Augustin, Alexander Studier‐Fischer, Tina Sackmann, Leon Kaulen, Anna Steyer, Walter Mier, David H Steel, Kanmin Xue, Gerd Uwe Auffarth, Philipp Uhl   +17 more
wiley   +1 more source

Molecular Surgery: Proteomics of a Rare Genetic Disease Gives Insight into Common Causes of Blindness

iScience, 2020
Summary: Rare diseases are an emerging global health priority. Although individually rare, the prevalence of rare “orphan” diseases is high, affecting approximately 300 million people worldwide.
Gabriel Velez, Vinit B. Mahajan
doaj   +1 more source

Preoperative electrophysiological characterization of patients with primary macula-involving rhegmatogenous retinal detachment [PDF]

, 2018
Purpose: To determine 1) which components of retinal function are impaired after rhegmatogenous retinal detachment, 2) which outer retinal pathways (rod- or cone-driven) are more severely affected, and 3) whether there is concomitant inner retinal ...
Apte, Rajendra, Lin, Jonathan, Sein, Julia, Van Stavern, Gregory   +3 more
core   +3 more sources