Results 91 to 100 of about 3,092 (233)

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Water, water, every where—the advent of hydrated pili structure

The FEBS Journal, EarlyView.
Protein structure is defined by its surrounding water. Naturally, this is also true for the gigantic protein filaments that pathogenic bacteria use to attach to and colonize their host cells. Structures of these filaments for which water can be identified with high confidence have stayed elusive for the longest time.
Hiroya Oki, Hideki Shigematsu, Kazuki Kawahara, Christoph Gerle   +3 more
wiley   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Cytocompatible and osteoconductive silicon oxycarbide glass scaffolds 3D printed by DLP: a potential material for bone tissue regeneration

Frontiers in Bioengineering and Biotechnology
Bone lesions affect individuals of different age groups, compromising their daily activities and potentially leading to prolonged morbidity. Over the years, new compositions and manufacturing technologies were developed to offer customized solutions to ...
Matheus Versão Carnieri, Daniele de Freitas Garcia, Rafael Voltolini, Neri Volpato, Marcio Mafra, Euclides Alexandre Bernardelli, Marco Augusto Stimamiglio, Carmen Kuniyoshi Rebelatto, Alejandro Correa, Lucas Freitas Berti, Bruna Hilzendeger Marcon, Bruna Hilzendeger Marcon   +11 more
doaj   +1 more source

Bioinspired Thermosensitive Hydrogel as a Vitreous Substitute: Synthesis, Properties, and Progress of Animal Studies. [PDF]

Materials (Basel), 2020
Laradji A, Shui YB, Karakocak BB, Evans L, Hamilton P, Ravi N.   +5 more
europepmc   +1 more source

Sodium–glucose cotransporter 2 inhibition and injection burden in mild diabetic macular edema: An exploratory post hoc analysis of the COMET trial

Journal of Diabetes Investigation, EarlyView.
Combining oral sodium‐glucose cotransporter 2 inhibitors with reduced intravitreal injections of anti‐vascular endothelial growth factor showed potential efficacy for mild diabetic macular edema. ABSTRACT Aims To investigate the potential of sodium–glucose cotransporter 2 inhibitors (SGLT2i) as a less invasive treatment option for mild diabetic macular
Yoko Takatsuna, Ryoichi Ishibashi, Masaya Koshizaka, Tomoaki Tatsumi, Takayuki Baba, Shuichi Yamamoto, Koutaro Yokote   +6 more
wiley   +1 more source

Advances in high‐resolution cryo‐volume electron microscopy (cvEM) imaging for unicellular and multicellular organisms

Journal of Microscopy, EarlyView.
Abstract Cryo‐Focused Ion Beam Scanning Electron Microscopy (cryoFIB‐SEM) using samples fixed by high‐pressure freezing uniquely enables high‐resolution cryo‐volume Electron Microscope (cvEM) images of cell ultrastructure to be obtained from whole cells and complex tissues in their near native state. As the freezing process also preserves fluorescence,
Maryna Kobylynska, Daniel Nicholls, Zoe Broad, Jack Wells, Alex Robinson, Stefania Marcotti, Damien McGrouther, Ch'ng Q‐L, Genoveva Esteban, Nigel Browning, Roland Fleck   +10 more
wiley   +1 more source

Neural modulation of ocular immunity: Exploring a sympathetic‐macrophage neuroimmune link in the human ciliary body

Journal of Anatomy, EarlyView.
Using microscopy and 3D confocal imaging on seven cadaveric eyes, we identified sympathetic nerves closely associated with β₂‐adrenergic receptor‐expressing macrophages in the human ciliary body (CB). These findings suggest a sympathetic‐macrophage neuroimmune link in the CB, potentially influencing ocular inflammation and degeneration, warranting ...
Tanya S. Karakyriakou, Claire Mackaaij, Mark van Zijverden, Hendrik A. Messal, Jeannette Ossewaarde‐van Norel, Ronald L. A. W. Bleys, Cindy G. J. Cleypool   +6 more
wiley   +1 more source

Enhance the viscosity of polydimethylsiloxane by controlling the volume ratio of monomer and chain terminator

AIP Advances
The production of polydimethylsiloxane (PDMS) as a vitreous substitute in Indonesia has been carried out. In our previous study, a good quality of low viscosity PDMS was well provided using a low-grade octamethylcyclotetrasiloxane (D4) monomer.
D. G. Auliya, S. Setiadji, Fitrilawati, A. S. Kartasasmita, Risdiana   +4 more
doaj   +1 more source

Magnetic properties of geraisites, the first tektite strewn field identified in Brazil

Meteoritics &Planetary Science, EarlyView.
Abstract Geraisites are a newly recognized class of tektite from Brazil. They occur as centimeter‐sized, elongated to subspherical bodies scattered across surface gravel and shallow subsurface layers within a ~90‐km‐long strewn field extending between the municipalities of São João do Paraíso and Curral de Dentro, near the border between the states of ...
Melissa De Andrade Nunes, Ricardo I. F. Trindade, João Pedro Rodriguez Pinto, Alvaro P. Crósta, Gabriel G. Silva, Ludovic Ferrière, Camila R. Sales, Giovanna M. Tosi   +7 more
wiley   +1 more source