Results 51 to 60 of about 208,965 (228)

Ex vivo biophysical characterization of a hydrogel-based artificial vitreous substitute.

PLoS ONE, 2019
PurposeTo characterize the biophysical properties of an artificial vitreous body substitute (VBS), which consists of a biocompatible, cross-linked, hyaluronic acid (HA)-based hydrogel, by analysing the VBS's influence on intraocular pressure (IOP) and ...
Kai Januschowski, Sven Schnichels, José Hurst, Christine Hohenadl, Charlotte Reither, Annekatrin Rickmann, Lisa Pohl, Karl-Ulrich Bartz-Schmidt, Martin S Spitzer   +8 more
doaj   +1 more source

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Advanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup, Sabrina Leslie, Miffy Hok Yan Cheng, Pieter R. Cullis   +12 more
wiley   +1 more source

A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization

Advanced Materials, EarlyView.
In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren, Alex Wu, Lucas Ramirez, Yaqing Huang, Connor Amelung, Sophia Saxonhouse, Sharon Gerecht   +6 more
wiley   +1 more source

Self‐Sealing Microneedles Improve Precision and Reduce Reflux in Subretinal Cell Transplantation

Advanced Materials Technologies, EarlyView.
Ultrafine 49G microneedles enable subretinal delivery of induced pluripotent stem cell‐derived retinal pigment epithelial cells through a 50 µm outer diameter tip. Compared with conventional 38G microcannulas, these microneedles reduce cell suspension reflux in a rabbit model, highlighting the potential of microinvasive delivery instruments to improve ...
Jared Ching, Hinako Ichikawa, Aya Motoyoshi, Shin Tanaka, Liam Morrow, Satoshi Shirae, Noriko Sakai, Shohei Kitahata, Michiko Mandai, Kazuaki Kadonosono   +9 more
wiley   +1 more source

Design of an Injectable in Situ Gelation Biomaterials for Vitreous Substitute [PDF]

, 2011
To adapt the physical properties of living materials to their biological function, nature developed various types of polymers with outstanding physical behavior.
Martin E. Vigild, Masahiko Annaka, Annaka, Masahiko, Vigild, Martin Etchells, Ueda, Tetsuo, Tsuji, Souichiro, Souichiro Tsuji, Vigild, Martin E., Kell Mortensen, Mortensen, Kell, Toyoaki Matsuura, Tetsuo Ueda, Matsuura, Toyoaki, Tsujinaka, Hiroki, Hiroki Tsujinaka, Tsujinaka, Hiroki (author), Tsuji, Souichiro (author), Annaka, Masahiko (author), Matsuura, Toyoaki (author), Ueda, Tetsuo (author), Mortensen, Kell (author), Vigild, Martin E. (author)   +21 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Predictive factors for anterior chamber fibrin formation after vitreoretinal surgery

Revista Brasileira de Oftalmologia, 2014
Purpose: The aim of this study was to investigate possible predictive factors related to anterior chamber fibrin formation after vitreoretinal surgery in a large series of patients.
Leonardo Provetti Cunha, Luciana Virgínia Ferreira Costa-Cunha, Carolina Ferreira Costa, Ronaldo Rocha Bastos, Tiago dos Santos Prata, Mário Luiz Ribeiro Monteiro   +5 more
doaj   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Vitreous Substitutes in Vitreoretinal Surgery: From Native Vitreous Physiology to Bioengineered Experimental Replacements

Journal of Functional Biomaterials
The vitreous body is not only a transparent filling material of the posterior segment; it is a soft, hydrated, and biologically active matrix that supports structural, optical, and biochemical homeostasis. Vitrectomy therefore leaves a functional deficit
Alessandro Avitabile, Ludovica Cannizzaro, Dario Rusciano   +2 more
doaj   +1 more source

Influence of Siluron® insertion on model drug distribution in the simulated vitreous body

Current Directions in Biomedical Engineering, 2016
Biorelevant in vitro test systems may be helpful to understand the in vivo behaviour of modern intravitreal dosage forms such as implants and injections.
Stein Sandra, Bogdahn Malte, Weitschies Werner, Seidlitz Anne   +3 more
doaj   +1 more source