Results 61 to 70 of about 208,965 (228)

Investigating Ex Vivo Animal Models to Test the Performance of Intravitreal Liposomal Drug Delivery Systems

Pharmaceutics, 2021
There is a strong need for innovative and efficient drug delivery systems for ocular therapy development. However, testing intravitreal drug delivery systems without using live animals is challenging.
Gustav Christensen, Leon Barut, Dileep Urimi, Nicolaas Schipper, François Paquet-Durand   +4 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Disorder Beats Order: Carbon Microstructure Steers Radical Versus Cationic Pathways in Kolbe Electrolysis

Angewandte Chemie, EarlyView.
Less graphitic, more Kolbe: carbon microstructure steers selectivity in Kolbe electrolysis. Disordered, sp3‐rich carbon electrodes with high charge‐transfer resistance favor surface radical pathways, giving about an order of magnitude more Kolbe dimer than graphitized sp2‐rich counterparts.
Md Mosaddek Hossen, Thy Ho, Bin Wang, Jean‐Philippe Tessonnier   +3 more
wiley   +2 more sources

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Understanding and Designing Phase Change Materials: Insights From Atom Probe Tomography

Advanced Science, EarlyView.
Atom probe tomography can distinguish metallic, covalent, and metavalent bonds based upon their bond rupture; in particular, the probability to form more than one ion (PME) in laser‐assisted field evaporation. These findings open new avenues in understanding and designing phase change materials (PCMs) since they allow quantification of bonds in solids ...
Jan Köttgen, Nils von den Driesch, Alexander Pawlis, Matthias Wuttig   +3 more
wiley   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Evolution of Vitreous Substitutes

, 2015
Evolution of Vitreous Substitutes: Ravi Bypareddy MD, DNB, Obuli Ramchandran N. MBBS, Koushik Tripathy MD, DNB, Subodh Kumar Singh MBBS, Harshinder Singh MD, Rohan Chawla MD, Rajpal Vohra MD, Yog Raj Sharma MSDOS times, Vol.
Bypareddy, Ravi, Ramchandran N, Obuli, Tripathy, Koushik, Kumar Singh, Subodh, Singh, Harshinder, Chawla, Rohan, Vohra, Rajpal, Raj Sharma, Yog   +7 more
openaire   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Silicone Oil Induced Glaucoma

Delhi Journal of Ophthalmology, 2018
Silicone oil (SO) is a vitreous substitute which is widely used to provide long term intraocular tamponade in retinal surgery. Transient or permanent rise in intraocular pressure is a common complication of silicone oil injection following pars plana ...
Madhu Bhoot, Ankita Agarwal, Suneeta Dubey, Julie Pegu, Monica Gandhi   +4 more
doaj   +1 more source

Contact Angle as Characterization Method for Vitreous Humor and Vitreous Humor Substitute Gels

, 2022
Purpose: In clinical ophthalmology, intraocular injections and long-acting implants are currently utilized to facilitate controlled drug release into the eye. However, in vivo pharmacokinetic testing not possible due to the inaccessibility of intraocular
Jacobsen, Dylan
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