Results 51 to 60 of about 20,449 (205)

Proteomics of Urinary Extracellular Vesicles Highlight the Involvement of Vitronectin and the Fibrinolytic and TNF Pathways as Mechanisms Underlying Renal Fibrosis in Kidney Transplant Patients

Journal of Extracellular Biology
Vitronectin (VTN) is a potential non‐invasive biomarker for renal fibrosis, originally described in urinary extracellular vesicles (uEV) from kidney transplant patients (KTx).
Marta Clos‐Sansalvador, Sergio G. Garcia, Paula Rodríguez‐Martínez, Marta Sanroque‐Muñoz, Miriam Font‐Morón, Cristina Grange, Benedetta Bussolati, Marcella Franquesa, Javier Juega, Francesc E. Borràs   +9 more
doaj   +1 more source

Vitronectin promotes proliferation and metastasis of cervical cancer cells via the epithelial-mesenchymal transition

Frontiers in Oncology
BackgroundVitronectin (VTN) is a multifunctional glycoprotein in blood and the extracellular, which could be an effective biomarker for many cancers. However, its role in cervical cancer is under investigated.
Yao Lin, Yao Lin, Lihong Bian, Lihong Bian, Guangwei Zhu, Bin Zhang, Bin Zhang   +6 more
doaj   +1 more source

MXene Bioinks for 3D Bioprinting: Design and Translation

Small, EarlyView.
This study establishes a comprehensive framework for MXene‐based bioinks in 3D bioprinting, highlighting the interplay between rheological engineering and electroactive hydrogels. By optimizing electrical percolation and mediated signaling, these formulations drive tissue‐specific biological outcomes and accelerated regeneration.
Begüm Sarac, Seydanur Yücer, Fatih Ciftci   +2 more
wiley   +1 more source

Characterization of the modular design of the autolysin/adhesin Aaa from Staphylococcus aureus. [PDF]

PLoS ONE, 2012
BACKGROUND: Staphylococcus aureus is a frequent cause of serious and life-threatening infections, such as endocarditis, osteomyelitis, pneumonia, and sepsis. Its adherence to various host structures is crucial for the establishment of diseases. Adherence
Nina Hirschhausen, Tim Schlesier, Georg Peters, Christine Heilmann   +3 more
doaj   +1 more source

Hydrolysis of Platelet Vitronectin by Calpain [PDF]

Journal of Biological Chemistry, 1996
Vitronectin (Vn) is not only a major adhesive glycoprotein present in platelets but also regulates proteolytic enzyme cascades, including the blood coagulation, fibrinolytic, and complement systems. In human platelet lysates prepared by freeze-thawing or by the addition of nonionic detergent, the Vn antigen content was drastically reduced in comparison
openaire   +2 more sources

Hierarchically Rough rGO/HAp Nanocoatings on SLM Ti–6Al–4 V Implants for Enhanced Biointegration

Small, EarlyView.
This study investigates HAp/rGO bioactive coatings on Ti‐6Al‐4V fixation implants fabricated by selective laser melting with systematically varied volumetric energy density to tailor the as‐built surface state. Composite coatings were deposited by electrophoretic deposition and characterized using micro‐CT, profilometry, FESEM/EDS, and detailed XPS to ...
Muhammad Usama Zaheer, Vahid Jahed, Rajveer Singh Rajaura, Fatemeh Rastegar Adib, Muhammad Hassan Razzaq, Gökhan Demirel, Mobarak Abu Mraheil, Thaqif El Khassawna, Mehmet Fatih Aycan, Yogendra Kumar Mishra   +9 more
wiley   +1 more source

Spatial Characterization of the Human Meniscus: Bridging Biomechanics and Biochemistry Using Atomic Force Microscopy Micro‐Indentation and Mass Spectrometry Imaging

Small Methods, EarlyView.
A multimodal imaging approach combines AFM micro‐indentation and MALDI mass spectrometry imaging on the same fresh‐frozen human meniscus section to directly associate microscale mechanics with molecular composition. Collagen‐rich regions exhibit increased stiffness, whereas zones enriched in other extracellular matrix proteins are mechanically less ...
Aleksandra N. Lebedeva, Martin Handelshauser, Orestis G. Andriotis, Lena Hirtler, Martina Marchetti‐Deschmann, Philipp J. Thurner   +5 more
wiley   +1 more source

Polypropylene Nanoplastic Exposure to Respiratory Epithelial Barrier‐On‐Chip and Interfacial Interactions With Human Serum Albumin

Allergy, EarlyView.
Exposure to 305 nm PP NPs significantly disrupts the airway barrier‐on‐chip, reducing TEER, suppressing ZO‐1/ACE2 expression, and triggering ROS‐mediated apoptosis. In biological media, PP NPs exhibit a biphasic adsorption pattern, leading to the formation of a protein corona that increases their size to 364 nm.
Omur Sert, Eyup Bilgi, Reyhan Coban, Pelin Saglam‐Metiner, Basar Dogan, Zeynep Imir‐Tekneci, Suleyman Selim Cinaroglu, Ozlem Goksel, Ceyda Oksel Karakus, Ozlem Yesil‐Celiktas   +9 more
wiley   +1 more source

[Vitronectin in children with renal disease--2. Examination of urinary vitronectin excretion].

Nihon Jinzo Gakkai shi, 1995
Urinary vitronectin excretion was measured by ELISA in healthy and various renal diseases children. In 36 healthy children, urinary vitronectin was excreted at low levels in the range of 0-2.71 (0.187 +/- 0.655) micrograms/g.Cre. Urinary Vitronectin and the positive ratio in various renal diseases were as follows: IgA nephropathy: 0-59.22 (3.420 +/- 9 ...
TAKAHASHI, Tsutomu, INABA, Susumu, OKADA, Toshio   +2 more
openaire   +2 more sources

Mesenchymal Stem Cells From a Klinefelter Syndrome Patient: Functional Characterization and Therapeutic Implications

Andrology, EarlyView.
ABSTRACT Background Cell therapy, particularly those utilizing mesenchymal stem/stromal cells (MSCs), is gaining traction as a therapeutic option for regenerative treatment in patients with limited therapeutic options. Although the safety of MSC‐based interventions is well established, uncertainties remain regarding how genetic abnormalities and ...
Marzena Zychowicz, Wioletta Lech, Anna Figiel‐Dabrowska, Marta Kot, Magdalena Murzyn, Natalia Malawska, Barbara Pienkowska‐Grela, Zuzanna Sandowska‐Markiewicz, Iwona Ziolkowska‐Suchanek, Agnieszka Zimna, Tomasz Oldak, Natalia Rozwadowska, Anna Sarnowska   +12 more
wiley   +1 more source