Results 51 to 60 of about 16,357 (238)

SUDEP and mortality in developmental and epileptic encephalopathies: A meta‐analysis of randomized clinical trials and extension studies

Epilepsia, EarlyView.
Abstract Objective Developmental and epileptic encephalopathies (DEEs) are associated with high premature mortality and increased risk of sudden unexpected death in epilepsy (SUDEP). However, epidemiological data remain limited, particularly for specific syndromes such as Dravet syndrome (DS), Lennox–Gastaut syndrome (LGS), and infantile epileptic ...
Pierludovico Moro, Maria Sole Borioni, Adolfo Mazzeo, Enrico Cocchi, Carlo Di Bonaventura, Emanuele Cerulli Irelli   +5 more
wiley   +1 more source

Chronic vagal nerve stimulation has no effect on tachycardia‐induced heart failure progression or excitation–contraction coupling

Physiological Reports, 2020
Autonomic dysregulation plays a key role in the development and progression of heart failure (HF). Vagal nerve stimulation (VNS) may be a promising therapeutic approach. However, the outcomes from clinical trials evaluating VNS in HF have been mixed, and
Emma J. Radcliffe, Charles M. Pearman, Amy Watkins, Michael Lawless, Graeme J. Kirkwood, Sophie N. Saxton, David A. Eisner, Andrew W. Trafford   +7 more
doaj   +1 more source

Differential effects of vagus nerve stimulation paradigms guide clinical development for Parkinson’s disease

Brain Stimulation, 2020
Background: Vagus nerve stimulation (VNS) modifies brain rhythms in the locus coeruleus (LC) via the solitary nucleus. Degeneration of the LC in Parkinson’s disease (PD) is an early catalyst of the spreading neurodegenerative process, suggesting that ...
Ariana Q. Farrand, Ryan S. Verner, Ryan M. McGuire, Kristi L. Helke, Vanessa K. Hinson, Heather A. Boger   +5 more
doaj   +1 more source

Stereo‐electroencephalography–guided responsive neuromodulation: A propensity‐matched cohort study

Epilepsia, EarlyView.
Abstract Objective The optimal pre‐implantation evaluation and surgical targeting strategies for responsive neurostimulation (RNS) in patients with unresectable, drug‐resistant focal epilepsy continue to be debated. Although stereo‐electroencephalography (sEEG) is central to characterizing the seizure‐onset zone, its role in preoperative testing for ...
David Botros, Julian Brown, John D. Rolston, Paul A. House, Amir Arain, Matthew Jensen, Blake Newman, Brian Johnson, Sindhu Richards, Angela Peters, Shervin Rahimpour, Ben Shofty   +11 more
wiley   +1 more source

The Role of the Vagus Nerve in Depressive Disorders: A Literature Review and the Potential of Vagotomy to Create a Depression Phenotype in Rodents

Acta Medica Bulgarica
Major depressive disorder (MDD) affects 280 million people worldwide and is a major global health burden due to its link with suicide, physical comorbidities, and inadequate response to pharmacotherapy in many patients. The monoamine theory of depression
Ataker F., Pencheva D., Bakalov D.
doaj   +1 more source

Frequency-specific modulation of oscillatory activity in the rat auditory cortex by vagus nerve stimulation

Brain Stimulation, 2023
Background: We previously found that vagus nerve stimulation (VNS) strengthened stimulus-evoked activity in the superficial layer of the sensory cortex but not in the deep layer, suggesting that VNS altered the balance between the feedforward (FF) and ...
Shinichi Kumagai, Tomoyo Isoguchi Shiramatsu, Akane Matsumura, Yohei Ishishita, Kenji Ibayashi, Yoshiyuki Onuki, Kensuke Kawai, Hirokazu Takahashi   +7 more
doaj   +1 more source

Effects of VNS FREQ on HR and heart period.

, 2018
Mean percent drop in HR for (A) P-VNS, (B) S-VNS (10%), and (C) S-VNS (20%) at different FREQ. Mean percent drop in Heart Period for (D) P-VNS, (E) S-VNS (10%), and (F) S-VNS (20%) at different FREQ.
Elizabeth M. Annoni (5029715), Bruce H. KenKnight (5029721), Elena G. Tolkacheva (3942389), Imad Libbus (5029718), Kanchan Kulkarni (5029712), Steven W. Lee (5029724)   +5 more
core   +1 more source

Effect of time to palliative epilepsy surgery on outcomes

Epilepsia, EarlyView.
Abstract Objective Epilepsy duration is a modifiable risk factor in the outcome of definitive epilepsy surgery; however, an analogous effect in palliative procedures has not been shown. We reviewed the Pediatric Epilepsy Surgery Database data for an association between epilepsy duration and seizure reduction in palliative procedures.
Robert M. Crutcher, David E. Horvat, Avery R. Caraway, Kristen H. Arredondo, Taylor J. Abel, Nitin Agarwal, Allyson L. Alexander, Dallas Michael Armstrong, Kurtis I. Auguste, Danilo Bernardo, Jeffrey Bolton, David Bonda, Dewi Frances Depositario‐Cabacar, Krista Eschbach, William D. Gaillard, Aran Groves, Jason S. Hauptman, Pradeep K. Javarayee, Cemal Karakas, Andrew T. Knox, Jenny J. Lin, Patricia E. McGoldrick, Derryl J. Miller, Edward John Novotny, Adam P. Ostendorf, Pilar D. Pichon, Shilpa B. Reddy, Debopam Samanta, Rani K. Singh, Janelle L. Wagner, Steven M. Wolf, Lily C. Wong‐Kisiel, Fernando N. Galan, M. Scott Perry, Michael A. Ciliberto   +34 more
wiley   +1 more source

Effects of vagal nerve stimulation parameters on heart rate variability in epilepsy patients

Frontiers in Neurology
IntroductionVagal nerve stimulation (VNS) is used as an alternative treatment in drug-resistant epilepsy patients. Effects of VNS on the cardiac autonomic system are controversial.
Ahmet Genç, Firdevs Ezgi Uçan Tokuç, Meltem Korucuk   +2 more
doaj   +1 more source

Acute Vagus Nerve Stimulation Facilitates Short Term Memory and Cognitive Flexibility in Rats

Brain Sciences, 2022
Vagus nerve stimulation (VNS) causes the release of several neuromodulators, leading to cortical activation and deactivation. The resulting preparatory cortical plasticity can be used to increase learning and memory in both rats and humans.
Christopher M. Driskill, Jessica E. Childs, Bemisal Itmer, Jai S. Rajput, Sven Kroener   +4 more
doaj   +1 more source