Results 61 to 70 of about 9,142 (197)

Vagus Nerve Stimulation Affects Pain Perception in Depressed Adults

Pain Research and Management, 2005
BACKGROUND: Previous research suggests that vagus nerve stimulation (VNS) affects pain perception in epilepsy patients, with acute VNS decreasing pain thresholds and chronic VNS treatment increasing pain thresholds.
Jeffrey J Borckardt, F Andrew Kozel, Berry Anderson, Angela Walker, Mark S George   +4 more
doaj   +1 more source

Epileptic drop attacks: More than just atonic seizures

Epilepsia Open, EarlyView.
Abstract “Drop attacks” are not officially defined by the International League Against Epilepsy. Seizures are characterized by a sudden loss of control over the trunk and posture, leading to falls and injuries, and resolving within a few seconds. Accurately diagnosing the type of seizure is usually difficult due to limitations in clinical documentation
Tomonori Ono, Kazuaki Sato, Ryoko Honda, Hiroshi Otsubo   +3 more
wiley   +1 more source

Effectiveness and safety of implantable vagus nerve stimulation in people with primary generalized tonic–clonic seizures

Epilepsia Open, EarlyView.
The impact of prompt diagnosis and treatment, and early predictors of outcome severity in this cohort. Abstract Objective Most therapies for drug‐resistant epilepsy (DRE) focus on focal‐onset seizures, the most common seizure types. Studying primary generalized tonic–clonic seizures (PGTCS) is more challenging due to diagnostic and recruitment ...
Katherine Eggleston, Justine Curley, Ryan Verner, Maxine Dibue, Charles Gordon, Gaia Giannicola, Kathryn Nichol   +6 more
wiley   +1 more source

Real‐world outcomes of responsive neurostimulation in patients with Lennox–Gastaut syndrome: A multicenter retrospective study

Epilepsia Open, EarlyView.
Abstract Objective Lennox–Gastaut syndrome (LGS) is a severe developmental and epileptic encephalopathy (DEE) characterized by multiple seizure types and high resistance to antiseizure medication (ASM), often necessitating nonpharmacologic therapies, including neuromodulation.
Shanna M. Swartwood, Robert J. Bollo, Catherine J. Chu, Alexandra L. Geffrey, Robert Mark Richardson, Hiroki Nariai, Aria Fallah, Samuel Ahn, Saadi Ghatan, Laura Chenevert, Maite La Vega‐Talbott, Audie C. Espinoza   +11 more
wiley   +1 more source

Sex Differences in Vagus Nerve Stimulation Effects on Rat Cardiovascular and Immune Systems

Frontiers in Neuroscience, 2020
BackgroundInvestigations into the benefits of vagus nerve stimulation (VNS) through pre-clinical and clinical research have led to promising findings for treating several disorders.
Farid Yaghouby, Kee Jang, Uyen Hoang, Sepideh Asgari, Srikanth Vasudevan   +4 more
doaj   +1 more source

Beyond seizures: A multidimensional approach to non‐seizure issues in Lennox–Gastaut syndrome. Insights from Italian experts

Epilepsia Open, EarlyView.
Abstract Non‐seizure issues (NSIs), including cognition, behavior/psychiatric symptoms, adaptive and social functioning, sleep, autonomic, and motor impairments, often shape day‐to‐day outcomes in Lennox–Gastaut syndrome (LGS) more than seizures, yet clinicians lack LGS‐specific, feasible assessment pathways.
Giancarlo Di Gennaro, Domenica Immacolata Battaglia, Paolo Bonanni, Gian Marco Duma, Antonietta Coppola, Edoardo Ferlazzo, Dario Pruna, Carlo Di Bonaventura   +7 more
wiley   +1 more source

Relative entropy as a biomarker for vagus nerve stimulation response in epilepsy: Insights from intracerebral electroencephalography

Epilepsia Open, EarlyView.
Abstract Objective This study aims to analyze differences in pre‐implantation invasive electroencephalographic (IEEG) data between vagus nerve stimulation (VNS) responders (>50% seizure reduction) and VNS nonresponders (<50% seizure reduction). Methods We retrospectively identified 19 patients with drug‐resistant focal epilepsy who underwent IEEG ...
Štěpán Erben, Jan Cimbálník, Eva Zatloukalová, Petra Búřilová, Jan Vinklárek, Barbora Sklenárová, Jan Chrastina, Eva Brichtová, Jitka Kočvarová, Ondřej Strýček, Martin Pail, Milan Brázdil, Irena Doležalová   +12 more
wiley   +1 more source

Real‐world effectiveness of cenobamate in drug‐resistant and ultra‐refractory epilepsy: A multicenter study

Epilepsia Open, EarlyView.
Abstract Objective To evaluate the real‐world effectiveness, safety, and treatment retention of cenobamate (CNB) in patients with drug‐resistant epilepsy (DRE), including ultra‐refractory epilepsy (URE), high seizure burden, and extensive prior treatment history.
Ondřej Strýček, Jana Amlerová, Martin Pail, Jitka Kočvarová, Jana Slonková, Martin Šimčík, Kateřina Stanzelová, Monika Šibalová, Petr Marusič, Milan Brázdil   +9 more
wiley   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Complex network behavior in epileptic patients treated with Vagus Nerve Stimulation (VNS): VNS responders exhibit a unique pattern, different from VNS non-responders and healthy controls

Frontiers in Neuroscience
IntroductionVagus nerve stimulation (VNS) represents an alternative treatment option in drug-resistant epilepsy. VNS patients can be categorized as responders (R, ≥50% seizure reduction) or non-responders (NR, < 50% seizure reduction).
Irena Dolezalova, Irena Dolezalova, Jan Chladek, Jan Chladek, Jan Chladek, Michal Macek, Jan Chrastina, Tereza Škvařilova, Petra Burilova, Stepan Erben, Eva Zatloukalova, Eva Zatloukalova, Milan Brazdil, Milan Brazdil   +13 more
doaj   +1 more source