Results 41 to 50 of about 208,904 (295)

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source

Experimental Identification of the Void Fraction in a Large Hydrodynamic Offset Halves Bearing

Lubricants
A common approach to optimising hydrodynamic journal bearings for power loss is to reduce the lubricant supply and direct the oil to specific bearing areas where it is needed to guarantee safe operation.
Alexander Engels, Sören Wettmarshausen, Michael Stottrop, Thomas Hagemann, Christoph Weißbacher, Hubert Schwarze, Beate Bender   +6 more
doaj   +1 more source

Void Fraction Measurment Beneath a Stationary Breaking Wave [PDF]

, 1998
Impedance based techniques have been used to quantify air entrainment by a stationary breaking wave at the bow of a ship. The present paper describes an impedance based void fraction meter which was developed to make measurements in this high speed ...
Brennen, Christopher E., Raichlen, Frederic, Waniewski, Tricia A.   +2 more
core  

Spatial and temporal tuning in void models for acceleration

, 2010
There has been considerable interest in recent years in cosmological models in which we inhabit a very large, underdense void as an alternative to dark energy.
Foreman, Simon, Moss, Adam, Scott, Douglas, Zibin, James P.   +3 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Experimental study and modelling of average void fraction of gas-liquid two-phase flow in a helically coiled rectangular channel [PDF]

, 2018
Void fraction is an important parameter in designing and simulating the relevant gas-liquid two-phase flow equipment and systems. Although numerous experimental research and modelling of void fraction in straight circular channels have been conducted ...
Cai, Bo, Cheng, Lixin, Jia, Yuting, Wang, Zhipeng, Xia, Guodong   +4 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An Investigation of Void Fraction in the Stratified/Annular Flow Regions in Smooth, Horizontal Tubes [PDF]

, 1999
Refrigerants R134a and R410A have been used for void fraction measurements in smooth horizontal tubes with diameters between 4mm and 7mm. Quality and mass flux were varied from 5% to 90% and 75 kglm2-s to 700 kglm2-s, respectively.
Chato, J.C., Graham, D.M., Kopke, H.R., Newell, T.A., Wilson, M.J., Yashar, D.A.   +5 more
core  

Preferential concentration of inertial sub-kolmogorov particles. The roles of mass loading of particles, Stokes and Reynolds numbers [PDF]

, 2016
Turbulent flows laden with inertial particles present multiple open questions and are a subject of great interest in current research. Due to their higher density compared to the carrier fluid, inertial particles tend to form high concentration regions ...
Aliseda, Alberto, Bourgoin, Mickael, Cartellier, Alain, Sumbekova, Sholpan   +3 more
core   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source