Results 41 to 50 of about 207,619 (294)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Experimental Identification of the Void Fraction in a Large Hydrodynamic Offset Halves Bearing
LubricantsA common approach to optimising hydrodynamic journal bearings for power loss is to reduce the lubricant supply and direct the oil to specific bearing areas where it is needed to guarantee safe operation.
Alexander Engels +6 more
doaj +1 more source
Void Fraction Measurment Beneath a Stationary Breaking Wave [PDF]
, 1998 Impedance based techniques have been used to quantify air entrainment by a stationary breaking wave at the bow of a ship. The present paper describes an impedance based void fraction meter which was developed to make measurements in this high speed ...
Brennen, Christopher E. +2 more
core
Analysis of the characteristic lengths in the bubble and slug flow regimes generated in a capillary T-junction [PDF]
, 2016 We present an analysis of the geometry of the continuous and disperse phases in the bubble and slug flow regimes in air–water mixtures generated in a capillary T-junction of 1 mm internal diameter.
Arias Calderón, Santiago +1 more
core +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Spatial and temporal tuning in void models for acceleration
, 2010 There has been considerable interest in recent years in cosmological models in which we inhabit a very large, underdense void as an alternative to dark energy.
Foreman, Simon +3 more
core +1 more source
Preferential concentration of inertial sub-kolmogorov particles. The roles of mass loading of particles, Stokes and Reynolds numbers [PDF]
, 2016 Turbulent flows laden with inertial particles present multiple open questions and are a subject of great interest in current research. Due to their higher density compared to the carrier fluid, inertial particles tend to form high concentration regions ...
Aliseda, Alberto +3 more
core +2 more sources
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Measurement and Modeling of Void Fraction in High Pressure Condensing Flows through Microchannels [PDF]
, 2014 This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the ...
4th Micro and Nano Flows Conference (MNF2014) +2 more
core
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source