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Preconditioning of the Myocardium by Volatile Anesthetics
Current Medicinal Chemistry-Cardiovascular & Hematological Agents, 2004Cardiovascular disease continues to be a major health problem. Tremendous efforts have been invested in clinical and laboratory research in the hopes of decreasing the risk of patients with cardiovascular disease undergoing cardiac and non-cardiac surgeries.
Kei Aizawa, Wai-Meng Kwok
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Journal of Cardiothoracic and Vascular Anesthesia, 2015
DEPENDING ON THE PATIENT’S individual risk profile, the likelihood of their suffering from a myocardial infarction during perioperative care is around 5%. The devastating effect of such a major cardiovascular event is tremendous, with a lethal outcome in
C. Lotz, F. Kehl
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DEPENDING ON THE PATIENT’S individual risk profile, the likelihood of their suffering from a myocardial infarction during perioperative care is around 5%. The devastating effect of such a major cardiovascular event is tremendous, with a lethal outcome in
C. Lotz, F. Kehl
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Anesthetic action of volatile anesthetics by using Paramecium as a model [PDF]
Journal of Huazhong University of Science and Technology [Medical Sciences], 2012 Although empirically well understood in their clinical administration, volatile anesthetics are not yet well comprehended in their mechanism studies. A major conundrum emerging from these studies is that there is no validated model to assess the presumed candidate sites of the anesthetics.
Jiao Liu +5 more
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Volatile Anesthetics and Neuroprotection
2015Since 1963, many studies have demonstrated the protective and preconditioning effects of volatile anesthetics on cerebral ischemia, and it has also been suggested that they can delay neuronal cell death, especially in the developing brain. Various molecular mechanisms involving the numerous pathways of the neuronal cell death cascade have been reported
Yasunori Mishima, Kazuo Ushijima
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Volatile anesthetic-induced cardiac preconditioning
Journal of Anesthesia, 2007Pharmacological preconditioning with volatile anesthetics, or anesthetic-induced preconditioning (APC), is a phenomenon whereby a brief exposure to volatile anesthetic agents protects the heart from the potentially fatal consequences of a subsequent prolonged period of myocardial ischemia and reperfusion.
Marko Ljubkovic +4 more
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Anesthesiology Clinics of North America, 1993
Summary In conclusion, the physiologic response to desflurane, for the most part, closely mimics the response to isoflurane. In the steady state, it is difficult to distinguish these two drugs on the basis of their effect on the central and regional hemodynamics, as well as on pulmonary function.
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Summary In conclusion, the physiologic response to desflurane, for the most part, closely mimics the response to isoflurane. In the steady state, it is difficult to distinguish these two drugs on the basis of their effect on the central and regional hemodynamics, as well as on pulmonary function.
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Volatile Anesthetics and Cardiac Function
Seminars in Cardiothoracic and Vascular Anesthesia, 2006All volatile anesthetics have been shown to induce a dose-dependent decrease in myocardial contractility and cardiac loading conditions. These depressant effects decrease myocardial oxygen demand and may, therefore, have a beneficial role on the myocardial oxygen balance during myocardial ischemia.
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Are volatile anesthetics cardioprotective agents?
Seminars in Anesthesia, Perioperative Medicine and Pain, 2001T HERE IS A renewed interest in the potential beneficial effects of volatile anesthetics as possible myocardial protective agents during cardiac surgery. The pendulum seems to be swinging away from the perception (in the 1980s) that volatile anesthetics might be harmful in the setting of coronary artery disease, to one in which volatile anesthetics ...
Imre Redai, Berend Mets, Marina Svyatets
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The conformational landscape of the volatile anesthetic sevoflurane.
Physical Chemistry, Chemical Physics - PCCP, 2010Most of the volatile haloorganic compounds used as anesthetics exhibit a heavy-atom frame large enough to allow for conformational changes. Even in the absence of directed intermolecular interactions, only some or just one of the possible conformations ...
A. Lesarri +4 more
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Extraction of mitochondrial proteins by volatile anesthetics
Biochimica et Biophysica Acta (BBA) - General Subjects, 1978Heavy beef heart mitochondria were exposed to controlled concentrations of several volatile anesthetics including halothane, enflurane and chloroform. These anesthetics caused a concentration-dependent release of protein from mitochondria with maximal release occurring at 17.5% halothane and less release at lower and higher concentrations. The proteins
U. Juhl +3 more
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