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Volatile anesthetic-induced preconditioning [PDF]
Perfusion, 2014 The myocardium has an innate ability to protect itself from ischemic events. This protection occurs when the myocardium is exposed to a brief ischemic period prior to a more extreme ischemic event. This is termed ischemic preconditioning. Ischemic preconditioning induces a series of molecular pathways that protect the cardiac myocyte; first, for a ...
T. Swyers, D. Redford, DF Larson
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Cardioprotection by volatile anesthetics
Vascular Pharmacology, 2005Preconditioning describes a very powerful endogenous mechanism by which the heart may be protected against ischemia and reperfusion injury. Transient administration of a volatile anesthetic before a prolonged ischemic episode reduces myocardial infarct size to a degree comparable to that observed during ischemic preconditioning.
Dorothee Weihrauch +8 more
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Mutagenicity of Volatile Anesthetics
Anesthesiology, 1976The mutagenicity of halothane was tested in an in-vitro microbial assay system employing two histidine-dependent mutants of Salmonella typhimurium, TA98 and TA100, Halothane in concentrations ranging from 0.1 to 30 per cent was incubated with bacteria in the presence or absence of a metabolic activation system prepared from either rat liver treated ...
Robert S. Wharton +5 more
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Preconditioning of the Myocardium by Volatile Anesthetics
Current Medicinal Chemistry-Cardiovascular & Hematological Agents, 2004Cardiovascular disease continues to be a major health problem. Tremendous efforts have been invested in clinical and laboratory research in the hopes of decreasing the risk of patients with cardiovascular disease undergoing cardiac and non-cardiac surgeries.
Kei Aizawa, Wai-Meng Kwok
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Anesthetic action of volatile anesthetics by using Paramecium as a model [PDF]
Journal of Huazhong University of Science and Technology [Medical Sciences], 2012 Although empirically well understood in their clinical administration, volatile anesthetics are not yet well comprehended in their mechanism studies. A major conundrum emerging from these studies is that there is no validated model to assess the presumed candidate sites of the anesthetics.
Jiao Liu +5 more
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Volatile Anesthetics and Neuroprotection
2015Since 1963, many studies have demonstrated the protective and preconditioning effects of volatile anesthetics on cerebral ischemia, and it has also been suggested that they can delay neuronal cell death, especially in the developing brain. Various molecular mechanisms involving the numerous pathways of the neuronal cell death cascade have been reported
Yasunori Mishima, Kazuo Ushijima
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Anesthesiology Clinics of North America, 1993
Summary In conclusion, the physiologic response to desflurane, for the most part, closely mimics the response to isoflurane. In the steady state, it is difficult to distinguish these two drugs on the basis of their effect on the central and regional hemodynamics, as well as on pulmonary function.
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Summary In conclusion, the physiologic response to desflurane, for the most part, closely mimics the response to isoflurane. In the steady state, it is difficult to distinguish these two drugs on the basis of their effect on the central and regional hemodynamics, as well as on pulmonary function.
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Volatile anesthetic-induced cardiac preconditioning
Journal of Anesthesia, 2007Pharmacological preconditioning with volatile anesthetics, or anesthetic-induced preconditioning (APC), is a phenomenon whereby a brief exposure to volatile anesthetic agents protects the heart from the potentially fatal consequences of a subsequent prolonged period of myocardial ischemia and reperfusion.
Marko Ljubkovic +4 more
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Volatile Anesthetics and Cardiac Function
Seminars in Cardiothoracic and Vascular Anesthesia, 2006All volatile anesthetics have been shown to induce a dose-dependent decrease in myocardial contractility and cardiac loading conditions. These depressant effects decrease myocardial oxygen demand and may, therefore, have a beneficial role on the myocardial oxygen balance during myocardial ischemia.
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Are volatile anesthetics cardioprotective agents?
Seminars in Anesthesia, Perioperative Medicine and Pain, 2001T HERE IS A renewed interest in the potential beneficial effects of volatile anesthetics as possible myocardial protective agents during cardiac surgery. The pendulum seems to be swinging away from the perception (in the 1980s) that volatile anesthetics might be harmful in the setting of coronary artery disease, to one in which volatile anesthetics ...
Imre Redai, Berend Mets, Marina Svyatets
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