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The Molecular Pharmacology of Volatile Anesthetics [PDF]

International Anesthesiology Clinics, 2015
Volatile anesthetics (VAs) transformed medical practice, although their impact may now be taken for granted. More than 150 years after they were introduced, VAs are now ubiquitous in operating rooms, but should not be considered commonplace in terms of our understanding of how they act.
openaire   +3 more sources

The use of volatile anesthetic agents for long-term critical care sedation (VALTS): study protocol for a pilot randomized controlled trial

Trials, 2015
BackgroundSedatives are administered to 85 % of intensive care unit (ICU) patients. The most commonly used sedatives are intravenous benzodiazepines and propofol. These agents are associated with over-sedation in 40 to 60 % of patients, which can lead to
A. Jerath, N. Ferguson, A. Steel, D. Wijeysundera, J. Macdonald, M. Wąsowicz   +5 more
semanticscholar   +1 more source

A randomized prospective study of desflurane versus isoflurane in minimal flow anesthesia using "equilibration time" as the change-over point to minimal flow

Journal of Anaesthesiology Clinical Pharmacology, 2012
Background: In the administration of minimal flow anesthesia, traditionally a fixed time period of high flow has been used before changing over to minimal flow.
Tanuja Mallik, S Aneja, R Tope, V Muralidhar   +3 more
doaj   +1 more source

Volatile anesthetic sevoflurane ameliorates endotoxin-induced acute lung injury via microRNA modulation in rats.

Biomedical Reports, 2015
Volatile anesthetics have a lung protective effect in acute lung injury (ALI). Our previous study showed sevoflurane affects the expression of microRNA (miRNA) that control various physiological systems by regulating messenger RNA (mRNA) expression ...
Tatsuro Otsuki, Masashi Ishikawa, Y. Hori, G. Goto, A. Sakamoto   +4 more
semanticscholar   +1 more source

Chromosomal damage among medical staff occupationally exposed to volatile anesthetics, antineoplastic drugs, and formaldehyde

Scandinavian Journal of Work, Environment & Health, 2013
OBJECTIVES: Structural chromosomal aberrations in blood lymphocytes represent a biomarker for cellular damage caused by genotoxic carcinogens and are an indicator of increased cancer risk.
Ludovit Musak, Zdenek Smerhovsky, Erika Halasova, Oto Osina, Lucia Letkova, Ludmila Vodickova, Veronika Polakova, Janka Buchancova, Kari Hemminki, Pavel Vodicka   +9 more
doaj   +1 more source

Atomistic study of lipid membranes containing chloroform: looking for a lipid-mediated mechanism of anesthesia. [PDF]

PLoS ONE, 2013
The molecular mechanism of general anesthesia is still a controversial issue. Direct effect by linking of anesthetics to proteins and indirect action on the lipid membrane properties are the two hypotheses in conflict.
Ramon Reigada
doaj   +1 more source

The Volatile Anesthetic Isoflurane Increases Endothelial Adenosine Generation via Microparticle Ecto-5′-Nucleotidase (CD73) Release

PLoS ONE, 2014
Endothelial dysfunction is common in acute and chronic organ injury. Isoflurane is a widely used halogenated volatile anesthetic during the perioperative period and protects against endothelial cell death and inflammation.
Mihwa Kim, Ahrom Ham, Katelyn, Yu-Mi Kim, K. Brown, H. Lee, Charles C Caldwell   +6 more
semanticscholar   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Effects of surgery and anesthetic choice on immunosuppression and cancer recurrence

Journal of Translational Medicine, 2018
Background The relationship between surgery and anesthetic-induced immunosuppression and cancer recurrence remains unresolved. Surgery and anesthesia stimulate the hypothalamic–pituitary–adrenal (HPA) axis and sympathetic nervous system (SNS) to cause ...
Ryungsa Kim
doaj   +1 more source

Anesthetic care for patients with anti-NMDA receptor encephalitis

Saudi Journal of Anaesthesia, 2020
Introduction: Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis, an autoimmune disorder resulting from antibodies directed against the NMDA (glutamate) receptor, is the second most frequent cause of immune-mediated encephalitis.
Faris Al Ghamdi, Joshua C Uffman, Stephani S Kim, Olubukola O Nafiu, Joseph D Tobias   +4 more
doaj   +1 more source