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Volatile Anesthetic Sedation for Critically Ill Patients

Anesthesiology
Volatile anesthetics have multiple properties that make them useful for sedation in the intensive care unit. The team-based approach to volatile anesthetic sedation leverages these properties to provide a safe and effective alternative to intravenous ...
Brian O'Gara, C. Boncyk, Andreas Meiser, Angela Jerath, M. Bellgardt, Matthieu Jabaudon, Jeremy R Beitler, Christopher G Hughes   +7 more
semanticscholar   +1 more source

Chromosomal damage among medical staff occupationally exposed to volatile anesthetics, antineoplastic drugs, and formaldehyde

Scandinavian Journal of Work, Environment & Health, 2013
OBJECTIVES: Structural chromosomal aberrations in blood lymphocytes represent a biomarker for cellular damage caused by genotoxic carcinogens and are an indicator of increased cancer risk.
Ludovit Musak, Zdenek Smerhovsky, Erika Halasova, Oto Osina, Lucia Letkova, Ludmila Vodickova, Veronika Polakova, Janka Buchancova, Kari Hemminki, Pavel Vodicka   +9 more
doaj   +1 more source

Neurotoxic Impact of Individual Anesthetic Agents on the Developing Brain

Children, 2022
Concerns about the safety of anesthetic agents in children arose after animal studies revealed disruptions in neurodevelopment after exposure to commonly used anesthetic drugs.
Dabin Ji, Joelle Karlik
doaj   +1 more source

Altered Anesthetic Sensitivity of Mice Lacking Ndufs4, a Subunit of Mitochondrial Complex I [PDF]

, 2012
RDP and AQ were supported by the Howard Hughes Medical Institute (HHMI). AQ was a recipient of MICINN postdoctoral mobility program fellowship from the Spanish Ministerio de Ciencia e Innovación.
Albert Quintana, Margaret M Sedensky, Philip G Morgan, Richard D Palmiter, Shane E Kruse   +4 more
core   +7 more sources

An innovative technique to improve safety of volatile anesthetics suction from the cardiopulmonary bypass circuit

Annals of Cardiac Anaesthesia, 2017
Context: Myocardial injury during cardiac surgery on cardiopulmonary bypass (CPB) is a major determinant of morbidity and mortality. Preclinical and clinical evidence of dose- and time-related cardioprotective effects of volatile anesthetic drugs exist ...
Francesco De Simone, Luigi Cassarà, Salvatore Sardo, Elena Scarparo, Omar Saleh, Caetano Nigro Neto, Alberto Zangrillo, Giovanni Landoni   +7 more
doaj   +1 more source

Perioperative and anesthetic deaths: toxicological and medico legal aspects [PDF]

, 2019
Background: Anesthesia has become safer during decades, though there is still a preventable mortality; the complexity of medical and surgical interventions, increasingly older and sicker patients, has created a host of new hazards in anesthesiology.
Argo A., Buscemi R., Karch S. B., Lanzarone A., Roccuzzo R., Zerbo S.   +5 more
core   +1 more source

The use of volatile anesthetic agents for long-term critical care sedation (VALTS): study protocol for a pilot randomized controlled trial

Trials, 2015
BackgroundSedatives are administered to 85 % of intensive care unit (ICU) patients. The most commonly used sedatives are intravenous benzodiazepines and propofol. These agents are associated with over-sedation in 40 to 60 % of patients, which can lead to
A. Jerath, N. Ferguson, A. Steel, D. Wijeysundera, J. Macdonald, M. Wąsowicz   +5 more
semanticscholar   +1 more source

The Molecular Pharmacology of Volatile Anesthetics [PDF]

International Anesthesiology Clinics, 2015
Volatile anesthetics (VAs) transformed medical practice, although their impact may now be taken for granted. More than 150 years after they were introduced, VAs are now ubiquitous in operating rooms, but should not be considered commonplace in terms of our understanding of how they act.
openaire   +3 more sources

A randomized prospective study of desflurane versus isoflurane in minimal flow anesthesia using "equilibration time" as the change-over point to minimal flow

Journal of Anaesthesiology Clinical Pharmacology, 2012
Background: In the administration of minimal flow anesthesia, traditionally a fixed time period of high flow has been used before changing over to minimal flow.
Tanuja Mallik, S Aneja, R Tope, V Muralidhar   +3 more
doaj   +1 more source

Atomistic study of lipid membranes containing chloroform: looking for a lipid-mediated mechanism of anesthesia. [PDF]

PLoS ONE, 2013
The molecular mechanism of general anesthesia is still a controversial issue. Direct effect by linking of anesthetics to proteins and indirect action on the lipid membrane properties are the two hypotheses in conflict.
Ramon Reigada
doaj   +1 more source