Results 71 to 80 of about 660,206 (287)

Research advances in dysphagia animal models

Animal Models and Experimental Medicine, EarlyView.
This review systematically summarizes the establishment, evaluation, and detection of dysphagia animal models in stroke, Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) in three kinds of experimental animals (including rodents, nonhuman primates, and other mammals), providing a basis for the selection of appropriate animal models of ...
Junhui Bai, Keling Cheng, Nannan Zhang, Yunfang Chen, Jun Ni, Zhiyong Wang   +5 more
wiley   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

Mitochondrial Disease and Anesthesia

Journal of Inborn Errors of Metabolism and Screening, 2017
It is increasingly common for children with mitochondrial disease to undergo surgery and anesthesia. Although many different anesthetics have been used successfully for these patients, serious, unexpected complications have occurred during and following ...
Vincent C. Hsieh MD, Elliot J. Krane MD, Philip G. Morgan MD   +2 more
doaj   +1 more source

Nonconventional Techniques in Plant Alkaloid Extraction: A Decade of Progress (2014–2023)

Chemistry &Biodiversity, EarlyView.
This figure seeks to represent the evolution of the different unconventional approaches that were adopted for the extraction of plant‐derived alkaloids during the decade from 2014 to 2023. ABSTRACT Plant metabolism encompasses primary and secondary pathways, with secondary metabolism yielding diverse natural products crucial for plant adaptation and ...
Victor Menezes Sipoloni, Milena Costa Bassicheto, Maria Vitória de Oliveira, Ana Beatriz dos Santos de Souza, Gabriella Melo Alves, Thiago André Moura Veiga   +5 more
wiley   +1 more source

Development of a simple method for differential delivery of volatile anesthetics to the spinal cord of the rabbit.

PLoS ONE, 2020
Emulsified volatile anesthetic can be directly injected into the circulation and eliminated from blood through lungs. Taking advantage of the unique pharmacokinetics of the emulsified volatile anesthetics, we aimed to develop a less traumatic method to ...
Peng Zhang, Yao Li, Ting Xu
doaj   +1 more source

Impact of anesthetic agents on the amount of bleeding during dilatation and evacuation: A systematic review and meta-analysis.

PLoS ONE, 2021
PurposePatients undergo dilatation and evacuation for abortion or miscarriage. However, bleeding is sometimes problematic. Despite reports on the association between volatile anesthetics and increased bleeding during the procedure, firm evidence is ...
Hyun Ah Lee, Hiromasa Kawakami, Takahiro Mihara, Hitoshi Sato, Takahisa Goto   +4 more
doaj   +1 more source

Secondary Metabolites Composition and Their Histochemical Localization in the Fruit of Piper malgassicum Papini, Palchetti, Gori and Rota Nodari (Piperaceae)

Chemistry &Biodiversity, EarlyView.
ABSTRACT The anatomy, histochemistry, and secondary metabolite composition were investigated on the drupes of Piper malgassicum, one of the components of the spice voatsiperifery pepper. The high amount of piperine recorded with high‐performance liquid chromatography with photodiode‐array detection analysis was localized with histochemistry mainly ...
Sara Falsini, Sara Ballantini, Alexander Pittella, Gelsomina Fico, Claudia Giuliani, Enrico Palchetti, Massimo Gori, Stefano Biricolti, Emilio Corti, Alessio Papini, Luca Calamai, Marzia Innocenti   +11 more
wiley   +1 more source

Intra and postoperative outcome of adding clonidine to bupivacaine in infraorbital nerve block for young children undergoing cleft lip surgery

Saudi Journal of Anaesthesia, 2011
Aims and Context: To evaluate the efficacy of adding clonidine to bupivacaine in bilateral infraorbital nerve block for hemodynamic changes, requirement of opioids, volatile agent, and muscle relaxants intraoperatively and relief of pain postoperatively .
Parul Jindal, Gurjeet Khurana, Sanjay Dvivedi, J P Sharma   +3 more
doaj   +1 more source

Stimulus Threshold for Providing Intraoperative Motor Evoked Potential

Haseki Tıp Bülteni, 2020
Aim:Intraoperative neurophysiological monitoring (IOM) has been increasingly used in surgeries associated with a risk of neurological impairment. Motor evoked potential (MEP), which is a part of intraoperative neurophysiological tests, evaluates motor ...
Emine Taşkıran, Dilek Akyüz
doaj   +1 more source

Isoflurane reversibly destabilizes hippocampal dendritic spines by an actin-dependent mechanism. [PDF]

PLoS ONE, 2014
General anesthetics produce a reversible coma-like state through modulation of excitatory and inhibitory synaptic transmission. Recent evidence suggests that anesthetic exposure can also lead to sustained cognitive dysfunction.
Jimcy Platholi, Karl F Herold, Hugh C Hemmings, Shelley Halpain   +3 more
doaj   +1 more source