Results 81 to 90 of about 681,564 (359)

Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus.

PLoS ONE, 2012
The anesthetic excitement phase occurring during induction of anesthesia with volatile anesthetics is a well-known phenomenon in clinical practice. However, the physiological mechanisms underlying anesthetic-induced excitation are still unclear.
Klaus Becker, Matthias Eder, Andreas Ranft, Ludwig von Meyer, Walter Zieglgänsberger, Eberhard Kochs, Hans-Ulrich Dodt   +6 more
doaj   +1 more source

A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: evidence for neural inertia. [PDF]

PLoS ONE, 2010
One major unanswered question in neuroscience is how the brain transitions between conscious and unconscious states. General anesthetics offer a controllable means to study these transitions. Induction of anesthesia is commonly attributed to drug-induced
Eliot B Friedman, Yi Sun, Jason T Moore, Hsiao-Tung Hung, Qing Cheng Meng, Priyan Perera, William J Joiner, Steven A Thomas, Roderic G Eckenhoff, Amita Sehgal, Max B Kelz   +10 more
doaj   +1 more source

Insights into Distinct Modulation of α7 and α7β2 Nicotinic Acetylcholine Receptors by the Volatile Anesthetic Isoflurane*

Journal of Biological Chemistry, 2013
Background: What determines hypersensitivity or insensitivity of β2-containing or α7 nAChRs to volatile anesthetics remains unclear. Results: Isoflurane binds to the EC end of the TM domain, modulates channel dynamics, and inhibits channel current in β2 ...
D. Mowrey, Qiang Liu, V. Bondarenko, Qiang Chen, E. Seyoum, Yan Xu, Jie Wu, P. Tang   +7 more
semanticscholar   +1 more source

Volatile anesthetics affect macrophage phagocytosis

PLOS ONE, 2019
Perioperative infections, particularly surgical site infections pose significant morbidity and mortality. Phagocytosis is a critical step for microbial eradication. We examined the effect of commonly used anesthetics on macrophage phagocytosis and its mechanism.The effect of anesthetics (isoflurane, sevoflurane, propofol) on macrophage phagocytosis was
Nathan Blazon-Brown, Renyu Liu, Weiming Bu, Erika Matsunami, Erika Matsunami, Hasan Babazada, Lifei Hou, Lifei Hou, Koichi Yuki, Koichi Yuki, Sophia Koutsogiannaki, Sophia Koutsogiannaki, Hui Zha, Hui Zha, Hui Zha, Kirsten C. Odegard, Kirsten C. Odegard, Roderic G. Eckenhoff   +17 more
openaire   +4 more sources

Sanggenol L Enhances Temozolomide Drug Sensitivity by Inhibiting Mitophagy and Inducing Apoptosis Through the Regulation of the TRIM16‐OPTN Axis in Glioblastoma

Advanced Science, EarlyView.
Sanggenol L, a flavonoid from mulberry, enhances glioblastoma sensitivity to temozolomide by inhibiting mitophagy and inducing apoptosis through TRIM16‐mediated OPTN degradation. In animal studies, liposomal delivery of Sanggenol L significantly improves the efficacy of its combination with TMZ, providing new insights into glioblastoma treatment ...
Hongbo Chang, Jianbing Hou, Xin Hu, Nana Hou, Minghao Xu, Yi Du, Jingyang Xu, Yongzhao Wang, Zhuohao Xie, Junbo Shi, Yundong Zhang, Hongjuan Cui   +11 more
wiley   +1 more source

Anesthetic Management of a Child with Mitochondrial Neurogastrointestinal Encephalopathy

Case Reports in Anesthesiology, 2015
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder associated with deficiency of thymidine phosphorylase (TP).
Vianey Q. Casarez, Acsa M. Zavala, Pascal Owusu-Agyemang, Katherine Hagan   +3 more
doaj   +1 more source

NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex

Advanced Science, EarlyView.
The primary neurological manifestations of tuberous sclerosis complex (TSC) are intractable epilepsy and intellectual disability. NEAT1 is differentially expressed in TSC‐related epilepsy and influences neuronal excitability by regulating the PI3K/AKT/mTOR signaling pathway.
Suhui Kuang, Tinghong Liu, Zhirong Wei, Jinshan Xu, Jiayi Han, Jiaqi Wang, Feng Zhai, Yiran Tian, Shuli Liang   +8 more
wiley   +1 more source

Ischemia-Reperfusion Injury and Volatile Anesthetics [PDF]

BioMed Research International, 2014
Ischemia-reperfusion injury (IRI) is induced as a result of reentry of the blood and oxygen to ischemic tissue. Antioxidant and some other drugs have protective effect on IRI. In many surgeries and clinical conditions IRI is counteract inevitable. Some anesthetic agents may have a protective role in this procedure.
openaire   +3 more sources

Robust Antifogging and Antifouling Coating Tailored with Zwitterionic Nanocellulose for Multi‐Functional Applications

Advanced Science, EarlyView.
A multifunctional, zwitterionic nanocellulose‐based coating is developed with lysine modification and polyacrylic acid integration, enabling robust antifogging and antifouling performance. With excellent hydrophilicity, mechanical strength, and biocompatibility, the coating shows promising potential for use in medical, food, and marine applications ...
Yanyi Duan, Jiangjiexing Wu, Aihua Qiao, Zheng Zhang, Jiaxin Shang, Xiaohui Mao, Xiaohui Yan, Nan Wang, Peng Zhong, Xiaobo Li, Xavier Banquy, Wei Qi, Rongxin Su   +12 more
wiley   +1 more source

Advances in Oncoanaesthesia and Cancer Pain

Cancer Treatment and Research Communications, 2021
Introduction:: The growing interest on how peri-‑operative interventions, especially regional anesthesia, during cancer surgery can alter oncological outcome increasing disease free survival is probably responsible for the birth of the new subspecialty ...
Mary Thomas
doaj   +1 more source