Effects of General Anesthetics on Excitatory and Inhibitory Synaptic Transmission in Area CA1 of the Rat Hippocamptls In Vitro [PDF]
, 1999 It is unclear whether general anesthetics induce enhancement of neural inhibition and/or attenuation of neural excitation.We studied the effects of pentobarbital (5xl0^mol/L), propofol (5x10^ mol/L), ketamine (10^ mol/L), halothane (1.5 vol%) and ...
Wakasugi Masahiro
core +1 more source
Rare but relevant: Hydrocarbons and sudden sniffing syndrome
Addiction, EarlyView.Abstract Inhaled hydrocarbon‐associated sudden collapse (IHASC), often referred to as ‘sudden sniffing death syndrome’ is a critical and often fatal event linked to the inhalation of volatile hydrocarbons, primarily occurring in adolescents and young adults. This syndrome manifests as sudden cardiac and/or respiratory arrest, typically occurring during
Ingrid Berling +1 more
wiley +1 more source
An In Silico Investigation of the Molecular Interactions between Volatile Anesthetics and Actin. [PDF]
Pharmaceuticals (Basel), 2023 Truglia B +7 more
europepmc +1 more source
Embedding Pharmacogenetics Into Clinical Practice to Improve Patient Outcomes
Annals of Human Genetics, EarlyView.ABSTRACT Pharmacogenomics, the use of germline genomic data to guide prescription to improve effective and safer medication, holds promise as a clinical intervention. To date in most health systems, there has been limited uptake of pharmacogenomic testing confined to a few single drug–gene associations.
John Henry McDermott +3 more
wiley +1 more source
Physiological parameter changes during field anaesthesia of bandicoots
Australian Veterinary Journal, EarlyView.Introduction Physiological responses to anaesthesia are described for the first time in eastern barred bandicoot (EBB; Perameles gunnii) and southern brown bandicoot (SBB; Isoodon obesulus). Method Two hundred and six field anaesthetics were carried out on free‐ranging bandicoots (82 EBB and 66 SBB) in North West Tasmania.
AF Bullen +3 more
wiley +1 more source
International Journal of Hyperthermia, 2019 Background: Studies suggest volatile anesthetics and opioids may enhance the malignant potential of cancer cells. The objective of this single institution retrospective study was to evaluate the survival impact of a multimodal opioid-sparing nonvolatile ...
Juan P. Cata +6 more
doaj +1 more source
Sustainability Standards in Pediatric Anesthesia: Quality Initiative to Reduce Costly Environmentally Harmful Volatile Anesthetics. [PDF]
Pediatr Qual Saf, 2023 Waberski AT +4 more
europepmc +1 more source
Deficiency of Aging‐Related Gene Chitinase‐Like 4 Impairs Olfactory Epithelium Homeostasis
Cell Proliferation, EarlyView.Deficiency of Chil4 impairs OE homeostasis through loss of sustentacular cells and a specific type of immature sensory neuron, cell cycle arrest in globose basal cells, and inflammatory activation in microglia‐like cells. ABSTRACT Mammalian olfactory epithelium (OE) undergoes consistent self‐renewal throughout life.
Tingting Wu +7 more
wiley +1 more source
Antagonism of propofol anesthesia by alkyl-fluorobenzene derivatives
Scientific ReportsDespite their frequent use across many clinical settings, general anesthetics are medications with lethal side effects and no reversal agents. A fluorinated analogue of propofol has previously been shown to antagonize propofol anesthesia in tadpoles and ...
Diana M. Plasencia +4 more
doaj +1 more source
Volatile anesthetics inhibit presynaptic cGMP signaling to depress presynaptic excitability in rat hippocampal neurons. [PDF]
Neuropharmacology, 2023 Speigel I +3 more
europepmc +1 more source