Results 61 to 70 of about 542,668 (236)

ZER1 Restrains Pressure Overload‐Induced Cardiac Remodeling by Targeting DVL2 for Gly/N‐Degron‐Dependent Degradation

Advanced Science, EarlyView.
Pressure overload suppresses cardiomyocyte ZER1, weakening CRL2Zer1‐mediated DVL2 degradation and allowing DVL2 accumulation. Elevated DVL2 activates CaMKII‐HDAC4‐MEF2C signaling, drives fetal gene reactivation, and promotes pathological remodeling.
Mingchao Jiang, Zhehao Lin, Lu Chen, Ying Ni, Jun Zhou, Wenjuan Zhang, Huilin Wang, Peifeng Ying, Xiu Lu, Kai Wang, Qingran Kong, Naxin Xu, Dingsheng Zhao, Jianwei Li, Guohui Zhong, Xingchen Meng, Sarkawt Hamad, Junmeng Zheng, Yuan Fu, Rongjiang Qin, Xuran Chu, Shangxuan Li, Youyou Li, Yili Wu, Yi Wang, Weihong Song, Yingxian Li, Shukuan Ling   +27 more
wiley   +1 more source

Massive carbon storage in convergent margins initiated by subduction of limestone

Nature Communications, 2021
Experiments and buoyancy calculations reveal that subduction of limestone results in massive carbon storage in arc lithosphere, forming an important carbon reservoir in convergent margins.
Chunfei Chen, Michael W. Förster, Stephen F. Foley, Yongsheng Liu   +3 more
doaj   +1 more source

Once despised now desired: innovative land use and management of multilayered Pumice Soils in the Taupo and Galatea areas, central North Island, New Zealand [PDF]

, 2014
The tour brings together innovative land use change and management associated with dairy farming, and land-based effluent disposal, on weakly weathered and multi-layered, glass-rich, Pumice Soils (Vitrands) in the Taupo and Galatea areas.
Lowe, David J., Laubscher, Nadia, Balks, Megan R.   +2 more
core  

ARC-Publicaties 16

, 2009
onderzoeksrappor
Ufkes, A. (ARC b.v.), Niekus, M.J.L.TH. (ARC b.v.)   +1 more
core   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Advances in New Zealand's Tephrochronostratigraphy Using Marine Drill Sites: The Neogene

Geochemistry, Geophysics, Geosystems, 2023
Three volcanic arcs have been the source of New Zealand's volcanic activity since the Neogene: Northland arc, Coromandel Volcanic Zone (CVZ) and Taupō Volcanic Zone (TVZ).
K. Pank, S. Kutterolf, J. L. Hopkins, K.‐L. Wang, H.‐Y. Lee, A. K. Schmitt   +5 more
doaj   +1 more source

Ferroelectric Catalysts in the Hydrogen Evolution Reaction: A Perspective

Advanced Science, EarlyView.
This perspective summarizes recent advances in ferroelectric (FE) catalysts for the hydrogen evolution reaction (HER). It first introduces HER fundamentals and FE mechanisms, then classifies FE catalysts into single‐phase, single‐atom‐modified, heterostructured, and other engineered types, with representative examples.
Rongxuan Lu, Weizhen Meng, Zhenxiang Cheng, Judy N. Hart, Michael Ferry, Sean Li, Wenxian Li   +6 more
wiley   +1 more source

ARC-Publicaties 105

, 2009
Aanleiding voor het Inventariserend Archeologisch Veldonderzoek fase 2 door middel van boringen is de aanleg van een nieuwe spoorlijn, de Hanzelijn, voor reizigers- en goederenvervoer tussen Lelystad en Zwolle.
Roller, G.J. de (ARC b.v.)
core   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Volcanic lateral collapse during arc–continent collision? Clues from Lutao Island (Northern Luzon Arc)

Geoscience Letters
Lateral collapses, also referred to as sector or flank collapses, are common in various types of volcanoes, particularly in island arc systems. Taiwan is situated in an active oblique collision zone, where the northern Luzon Arc converges with the ...
Huai-Yu Tang, Yu-Ming Lai, Sheng-Rong Song   +2 more
doaj   +1 more source