Results 51 to 60 of about 173,383 (330)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Improvement in Marine CSEM Imaging for Towed Electromagnetic Receivers Through Multirate Signal Processing and Adaptive Noise Suppression

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Multirate signal processing and adaptive filtering techniques have been widely employed to mitigate noise contamination and enhance the efficiency of data analysis.
Yu Long, Xiaochen Li, Dong Liang, Minghui Chen, Kai Chen   +4 more
doaj   +1 more source

Simulation of Near Horizontal Muons and Muon Bundles for the HAWC Observatory with CORSIKA

, 2017
The HAWC (High Altitude Water Cerenkov) gamma ray observatory observes muons with nearly-horizontal trajectories corresponding to zenith angles greater than $80^{0}$. HAWC is located at an altitude of 4100 meters a.s.l. (70 deg. atmospheric depth of 2400
Barber, Ahron S., Kieda, David B., Springer, R. Wayne   +2 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Detection and Monitoring of Mining-Induced Seismicity Based on Machine Learning and Template Matching: A Case Study from Dongchuan Copper Mine, China

Sensors
The detection and monitoring of mining-induced seismicity are essential for understanding the mechanisms behind earthquakes and mitigating seismic hazards.
Tao Wu, Zhikun Liu, Shaopeng Yan
doaj   +1 more source

AGU Centennial Grand Challenge: Volcanoes and Deep Carbon Global CO2 Emissions From Subaerial Volcanism—Recent Progress and Future Challenges

Geochemistry, Geophysics, Geosystems, 2020
Quantifying the global volcanic CO2 output from subaerial volcanism is key for a better understanding of rates and mechanisms of carbon cycling in and out of our planet and their consequences for the long‐term evolution of Earth's climate over geological
Tobias P. Fischer, Alessandro Aiuppa
doaj   +1 more source

Volcano Seismology

, 2001
New Manual of Seismological Observatory Practice 2 (NMSOP2)
openaire   +6 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Hazardousness of place : a new comparative approach to the Filipino past [PDF]

, 2016
© Ateneo de Manila University. The historiography of the Philippines has been largely bounded by the nation-state, which has defined how its past has been conceived and to whom its peoples are mainly compared.
Bankoff, Greg
core   +2 more sources