Results 51 to 60 of about 30,290 (300)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Volcanic and sedimentary processes in phreatomagmatic volcanoes [PDF]
, 1982 Phreatomagmatic volcanoes form when ascending magma explosively interacts with surface or groundwater at shallow depths. Three types of phreatomagmatic activity are recognised- phreaticp phreatomagmatic (s. s. ) and surtseyan - based on the degree of
Leys, C.A., Leys, Clyde Andrew
core
TSUNAMIGENIC SOURCES IN THE INDIAN OCEAN [PDF]
Science of Tsunami Hazards, 2008 Based on an assessment of the repeat periods of great earthquakes from past seismicity, convergence rates and paleoseismological results, possible future source zones of tsunami generating earthquakes in the Indian Ocean (possible seismic gap areas) are ...
B. K. Rastogi +2 more
doaj
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
RRS James Cook Cruise 10, 13 May-07 Jul 2007. Hotspot ecosystems in the NE Atlantic, UK contribution to the HERMES Project. Mud volcanoes in the Gulf of Cadiz; submarine canyons west of Portugal; submarine canyons in the northern Bay of Biscay [PDF]
, 2007 The major objective of RRS James Cook Cruise 10 was to increase our understanding of how seafloor environmental variables affect the biodiversity, structure, function and dynamics of faunal communities in two specific ‘biological hotspot’ environments ...
Masson, D.G., Weaver, P.P.E.
core
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Volcanic studies by members of the Royal Society of London 1665 - 1780 [PDF]
, 1971 Late seventeenth century ideas about volcanic activity were largely derived from classical sources. The Philosophical Transactions of the Royal Society of London provided a vehicle for publication of information about volcanoes where many ancient notions
Stokes, Evelyn
core
Geochemistry, Geophysics, Geosystems, 2020 Quantifying the global volcanic CO2 output from subaerial volcanism is key for a better understanding of rates and mechanisms of carbon cycling in and out of our planet and their consequences for the long‐term evolution of Earth's climate over geological
Tobias P. Fischer, Alessandro Aiuppa
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source