Results 131 to 140 of about 194,442 (307)

Designer genetically encoded voltage-dependent calcium channel inhibitors inspired by RGK GTPases. [PDF]

J Physiol, 2020
Colecraft HM.
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

A native prokaryotic voltage-dependent calcium channel with a novel selectivity filter sequence. [PDF]

Elife, 2020
Shimomura T, Yonekawa Y, Nagura H, Tateyama M, Fujiyoshi Y, Irie K.   +5 more
europepmc   +1 more source

N-type Ca2+ channels mediate the stimuli-dependent α-synuclein secretion in mouse striatum

npj Parkinson's Disease
The secretion of α-synuclein from presynaptic terminals is controlled by neuronal activity through a calcium-dependent mechanism. To address the role of voltage gated calcium channels in this process, we used reverse brain microdialysis to monitor α ...
Emmanouela Leandrou, Ioanna Chalatsa, Kostas Vekrellis, Evangelia Emmanouilidou   +3 more
doaj   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source

Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters

Advanced Biology, EarlyView.
Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams, Ana I Borrachero‐Conejo, Pratheepa Kumari Rasiah, Emanuela Saracino, Roberto Zamboni, Eric Duco Jansen, Valentina Benfenati, Anita Mahadevan‐Jansen   +7 more
wiley   +1 more source

Calcium channel voltage-dependent α2/δ subunit 2 (CACNA2D2) [PDF]

, 2013

openalex   +1 more source

Tetraspanin‐7 regulation of L‐type voltage‐dependent calcium channels controls pancreatic β‐cell insulin secretion [PDF]

, 2020
Matthew T. Dickerson, Prasanna K. Dadi, Regan B. Butterworth, Arya Y. Nakhe, Sarah M. Graff, Karolina E. Zaborska, Charles M. Schaub, David A. Jacobson   +7 more
openalex   +1 more source

Amide‐Linked Local Anesthetics Alter Tumor Biology in a Complex Human Tissue Model of Non‐Small Cell Lung Adenocarcinoma

Advanced Biology, EarlyView.
Amide local anesthetics (LA) affect tumor burden in various preclinical studies, possibly via their anti‐inflammatory properties. However, a translation into clinical evidence is still lacking. The current study demonstrates that LA ‐ even at clinically relevant concentrations – exert a strong anti‐tumoral effect in a complex ex vivo model patient ...
Juliane Krömer, Sebastian Krämer, Ngoc Anh Hoang, Doreen Sittig, Isabella Metelmann, Uta‐Carolin Pietsch, Sebastian N. Stehr, Sonja Kallendrusch, Tobias Piegeler   +8 more
wiley   +1 more source

Voltage‐dependent calcium and potassium channels in Schwann cells cultured from dorsal root ganglia of the mouse. [PDF]

, 1991
Thierry Amédée, Emmanuel Ellie, B. Dupouy, J.D. Vincent   +3 more
openalex   +1 more source