Results 41 to 50 of about 248,505 (393)

Identification of Residues in the N Terminus of α1B Critical for Inhibition of the Voltage-Dependent Calcium Channel by Gβγ

Journal of Neuroscience, 1999
To examine the role of the intracellular N terminus in the G-protein modulation of the neuronal voltage-dependent calcium channel (VDCC) α1B, we have pursued two routes of investigation.
C. Cantí, K. Page, G. Stephens, A. Dolphin   +3 more
semanticscholar   +1 more source

Targeted disruption of the voltage-dependent calcium channel alpha2/delta-1-subunit.

American Journal of Physiology. Heart and Circulatory Physiology, 2009
G. Fuller-Bicer, G. Varadi, Sheryl E. Koch, M. Ishii, I. Bódi, Nijiati Kadeer, J. Muth, G. Mikala, N. Petrashevskaya, M. A. Jordan, Sui-Po Zhang, N. Qin, C. M. Flores, Idit Isaacsohn, M. Váradi, Y. Mori, W. Jones, A. Schwartz   +17 more
semanticscholar   +3 more sources

Genetic Evidence Supporting the Role of the Calcium Channel, CACNA1S, in Tooth Cusp and Root Patterning

Frontiers in Physiology, 2018
In this study, we report a unique dominantly inherited disorganized supernumerary cusp and single root phenotype presented by 11 affected individuals belonging to 5 north-eastern Thai families.
Virginie Laugel-Haushalter, Supawich Morkmued, Supawich Morkmued, Corinne Stoetzel, Véronique Geoffroy, Jean Muller, Jean Muller, Anne Boland, Jean-François Deleuze, Kirsley Chennen, Kirsley Chennen, Waranuch Pitiphat, Hélène Dollfus, Hélène Dollfus, Karen Niederreither, Karen Niederreither, Agnès Bloch-Zupan, Agnès Bloch-Zupan, Agnès Bloch-Zupan, Patimaporn Pungchanchaikul   +19 more
doaj   +1 more source

Cdk5/p35 Regulates Neurotransmitter Release through Phosphorylation and Downregulation of P/Q-Type Voltage-Dependent Calcium Channel Activity

Journal of Neuroscience, 2002
Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase with close structural homology to the mitotic Cdks. The complex of Cdk5 and p35, the neuron-specific regulatory subunit of Cdk5, plays important roles in brain development ...
K. Tomizawa, J. Ohta, M. Matsushita, A. Moriwaki, Sheng-tian Li, K. Takei, H. Matsui   +6 more
semanticscholar   +1 more source

Voltage-Dependent Calcium Channels

, 2001
Voltage-activated calcium channels can be divided into two subgroups based on their activation threshold, low-voltage-activated (LVA) and high-voltage-activated (HVA). Auxiliary subunits of the HVA calcium channels contribute significantly to biophysical properties of the channels.
LUBICA LACINOVÁ, FRANZ HOFMANN
openaire   +2 more sources

Determinants of the voltage dependence of G protein modulation within calcium channel β subunits [PDF]

, 2008
CaVβ subunits of voltage-gated calcium channels contain two conserved domains, a src-homology-3 (SH3) domain and a guanylate kinase-like (GK) domain with an intervening HOOK domain. We have shown in a previous study that, although Gβγ-mediated inhibitory
A Hummer, A Meir, A Neely, AC Dolphin, AC Meir A Dolphin, AJ Butcher, Andriy V. Dresviannikov, Annette C. Dolphin, B Li, C Altier, C Canti, C Canti, D Bichet, D Walker, DC Bell, EA Ertel, F Bertaso, F Petegem Van, G Sandoz, GJ Stephens, GJ Stephens, J Barclay, J Leroy, Jerôme Leroy, JM Maltez, Karen M. Page, KM Page, L Berrou, L Birnbaumer, LP Jones, M Pragnell, M Waard De, MR Hanlon, MW Richards, MW Richards, N Qin, N Weiss, NL Brice, RM Cohen, SC Stotz, SX Takahashi, SX Takahashi, WA Catterall, Wendy S. Pratt, Y Opatowsky, YH Chen   +45 more
core   +2 more sources

Functional Coupling of Cav2.3 and BK Potassium Channels Regulates Action Potential Repolarization and Short-Term Plasticity in the Mouse Hippocampus

Frontiers in Cellular Neuroscience, 2019
Voltage-gated ion channels are essential for signal generation and propagation in neurons and other excitable cells. The high-voltage activated calcium-channel Cav2.3 is expressed throughout the central and peripheral nervous system, and within CA1 ...
Jakob J. Gutzmann, Lin Lin, Dax A. Hoffman   +2 more
doaj   +1 more source

Strategies for studying permeation at voltage-gated ion channels [PDF]

, 1991
Voltage-dependent ion channels are presently thought to consist of several distinct functional regions: (a) activation gates, (b) inactivation gates, and permeation pathways.
Lester, Henry A.
core   +1 more source

Medaka as a model for ECG analysis and the effect of verapamil

Journal of Pharmacological Sciences, 2018
The heart of the medaka, a small fish native to East Asia, has electrophysiological aspects similar to mammalian hearts. We found that the heart rates of medaka were more similar to humans than mice or rats.
Manabu Yonekura, Nami Kondoh, Chong Han, Yuichi Toyama, Takayoshi Ohba, Kyoichi Ono, Shirou Itagaki, Hirofumi Tomita, Manabu Murakami   +8 more
doaj   +1 more source

A Lipid Bilayer Formed on a Hydrogel Bead for Single Ion Channel Recordings

Micromachines, 2020
Ion channel proteins play important roles in various cell functions, making them attractive drug targets. Artificial lipid bilayer recording is a technique used to measure the ion transport activities of channel proteins with high sensitivity and ...
Minako Hirano, Daiki Yamamoto, Mami Asakura, Tohru Hayakawa, Shintaro Mise, Akinobu Matsumoto, Toru Ide   +6 more
doaj   +1 more source