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Terahertz Wave Enhances Permeability of the Voltage-Gated Calcium Channel.
Journal of the American Chemical Society, 2021A deficiency of Ca2+ fluxes arising from dysfunctional voltage-gated calcium channels has been associated with a list of calcium channelopathies such as epilepsy, hypokalemic periodic paralysis, episodic ataxia, etc.
Yangmei Li +4 more
semanticscholar +1 more source
The crystal structure of a voltage-gated sodium channel
Nature, 2011 Voltage-gated sodium (NaV) channels initiate electrical signalling in excitable cells and are the molecular targets for drugs and disease mutations, but the structural basis for their voltage-dependent activation, ion selectivity and drug block is ...
Jian Payandeh +2 more
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Current Opinion in Pharmacology, 2015
Voltage-gated sodium channels play a key role in the transmission of sensory information about the status of organs in the periphery. Sensory fibers contain a heterogeneous yet specific distribution of voltage-gated sodium channel isoforms. Major efforts by industry and academic groups are underway to develop medicines that interrupt inappropriate ...
Kevin, Kwong, Michael J, Carr
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Voltage-gated sodium channels play a key role in the transmission of sensory information about the status of organs in the periphery. Sensory fibers contain a heterogeneous yet specific distribution of voltage-gated sodium channel isoforms. Major efforts by industry and academic groups are underway to develop medicines that interrupt inappropriate ...
Kevin, Kwong, Michael J, Carr
openaire +2 more sources
Current Opinion in Pharmacology, 2001
Increased knowledge of the molecular diversity of sodium channel alpha- and beta-subunits, and their distribution of expression have been highlights of the past year. The development of subtype-specific channel blockers remains elusive, but the discovery of selective inhibitors such as mu-conotoxins promises useful antagonists in the near future.
J N, Wood, M, Baker
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Increased knowledge of the molecular diversity of sodium channel alpha- and beta-subunits, and their distribution of expression have been highlights of the past year. The development of subtype-specific channel blockers remains elusive, but the discovery of selective inhibitors such as mu-conotoxins promises useful antagonists in the near future.
J N, Wood, M, Baker
openaire +2 more sources
Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution
Nature, 2016Jianping Wu, Zhen Yan, Zhangqiang Li
exaly +2 more sources
Science's STKE, 2003
Ion channels and the electrical properties they confer on cells are involved in every human characteristic that distinguishes us from the stones in a field. Every perception, thought, movement, and heartbeat depends on electrical signals generated by the activity of ion channels.
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Ion channels and the electrical properties they confer on cells are involved in every human characteristic that distinguishes us from the stones in a field. Every perception, thought, movement, and heartbeat depends on electrical signals generated by the activity of ion channels.
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2008
How and where simple volatile organic molecules act in the central nervous system to cause loss of consciousness and insensitivity to pain has eluded investigation; yet remarkable progress has been made recently towards identifying possible molecular targets through which the mechanism of anesthesia is tranduced.
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How and where simple volatile organic molecules act in the central nervous system to cause loss of consciousness and insensitivity to pain has eluded investigation; yet remarkable progress has been made recently towards identifying possible molecular targets through which the mechanism of anesthesia is tranduced.
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2020
This chapter describes the main properties of a voltage-dependent channel presented firstly as a prototype of conducting channels, that is, pore-forming molecules managing transient transmembrane ion fluxes. At resting potential, the voltage sensor adopts a depolarized conformation, and the pore is closed.
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This chapter describes the main properties of a voltage-dependent channel presented firstly as a prototype of conducting channels, that is, pore-forming molecules managing transient transmembrane ion fluxes. At resting potential, the voltage sensor adopts a depolarized conformation, and the pore is closed.
openaire +1 more source
Voltage gating of ion channels
Quarterly Reviews of Biophysics, 1994Voltage-gated ion channels are membrane proteins that play a central role in the propagation and transduction of cellular signals (Hille, 1992). Calcium ions entering cells through voltage-gated calcium channels serve as the trigger for neurotransmitter release, muscle contraction, and the release of hormones. Voltage-gated sodium channels initiate the
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Ether-à-go-go encodes a voltage-gated channel permeable to K+ and Ca2+ and modulated by cAMP
Nature, 1993Andrea Brüggemann +3 more
semanticscholar +1 more source