Results 181 to 190 of about 101,918 (291)

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

The antipsychotic chlorpromazine reduces neuroinflammation by inhibiting microglial voltage-gated potassium channels. [PDF]

Glia
Lee HY, Lee Y, Chung C, Park SI, Shin HJ, Joe EH, Lee SJ, Kim DW, Jo SH, Choi SY.   +9 more
europepmc   +1 more source

Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism. [PDF]

Cell Death Dis, 2021
Styles FL, Al-Owais MM, Scragg JL, Chuntharpursat-Bon E, Hettiarachchi NT, Lippiat JD, Minard A, Bon RS, Porter K, Sukumar P, Peers C, Roberts LD.   +11 more
europepmc   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

H⁺ and Confined Water in Gating in Many Voltage-Gated Potassium Channels: Ion/Water/Counterion/Protein Networks and Protons Added to Gate the Channel. [PDF]

Int J Mol Sci
Kariev AM, Green ME.
europepmc   +1 more source

Neurodevelopmental features in KCNQ2 developmental and epileptic encephalopathy may have limited associations with KV7.2 dysfunction

Epilepsia Open, EarlyView.
Abstract Objective Variants in KCNQ2 encoding the voltage‐gated potassium channel KV7.2 are associated with developmental and epileptic encephalopathy (DEE) of varying severity. This study examined the relationship of KCNQ2 variant dysfunction with the neurodevelopmental phenotype of individuals with KCNQ2‐DEE. Methods A parent‐reported survey gathered
Jessa S. Bidwell, Carlos G. Vanoye, Reshma R. Desai, Anne T. Berg, Alfred L. George Jr   +4 more
wiley   +1 more source

A novel spider toxin as a selective antagonist of the Kv1 subfamily of voltage-gated potassium channels through gating modulation. [PDF]

J Biol Chem
Xiao Z, You X, Chen M, Li H, Chen B, Hu Z, You Q, Liu H, Zhao P, Zhou X, Liu Z.   +10 more
europepmc   +1 more source

Co-Application of Statin and Flavonoids as an Effective Strategy to Reduce the Activity of Voltage-Gated Potassium Channels Kv1.3 and Induce Apoptosis in Human Leukemic T Cell Line Jurkat. [PDF]

Molecules, 2022
Teisseyre A, Chmielarz M, Uryga A, Środa-Pomianek K, Palko-Łabuz A.   +4 more
europepmc   +1 more source

Harnessing Piezoelectric Biomaterials for Pathogenic Eradication and Tissue Regeneration

Exploration, EarlyView.
This review highlights recent advances in piezoelectric biomaterials for antibacterial therapy and tissue regeneration, discussing material classifications, catalytic mechanisms, property enhancements, biomedical applications, and future challenges in clinical translation.
Wenxuan Mao, Xiaoye Li, Ao He, Meng Ding, Yu Zhang, Zhuo Dai, Qiang Li, Weijun Xiu, Yanling Hu, Yongbin Mou, Dongliang Yang, Heng Dong   +11 more
wiley   +1 more source

Voltage-gated potassium channels are involved in oxymatrine-regulated islet function in rat islet β cells and INS-1 cells. [PDF]

Iran J Basic Med Sci, 2021
Gao J, Xia L, Wei Y.
europepmc   +1 more source