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Animal Toxins Acting on Voltage-Gated Potassium Channels
Current Pharmaceutical Design, 2008Animal venoms are rich natural sources of bioactive compounds, including peptide toxins acting on the various types of ion channels, i.e. K(+), Na(+), Cl(-) and Ca(2+). Among K+ channel-acting toxins, those selective for voltage-gated K(+) (Kv) channels are widely represented and have been isolated from the venoms of numerous animal species, such as ...
Stéphanie, Mouhat +3 more
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Clinical spectrum of voltage-gated potassium channel autoimmunity
Neurology, 2008To document neurologic, oncologic, and serologic associations of patients in whom voltage-gated potassium channel (VGKC) autoantibodies were detected in the course of serologic evaluation for neuronal, glial, and muscle autoantibodies.Indirect immunofluorescence screening of sera from 130,000 patients performed on a service basis for markers of ...
K M, Tan +4 more
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Voltage-gated potassium ion channels in colon cancer
Oncology Reports, 2002Voltage-gated potassium channels (VGPCs) have been previously implicated in cellular proliferation. In this study, the expression of VGPCs was examined by immunohistochemistry in seventy-four human colonic carcinoma specimens. Immunostaining for the Kv1.3 type VGPC was absent in two normal human colon specimens.
Mansoor, Abdul, Naseema, Hoosein
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Voltage-Gated Potassium Channels: Regulation by Accessory Subunits
The Neuroscientist, 2006Voltage-gated potassium channels regulate cell membrane potential and excitability in neurons and other cell types. A precise control of neuronal action potential patterns underlies the basic functioning of the central and peripheral nervous system. This control relies on the adaptability of potassium channel activities.
Yan, Li +2 more
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Pharmacology of Voltage-Gated Potassium Channels
2000Voltage-gated potassium (Kv) channels play an important role in many cellular functions correlated with changes in excitability. Their functions range from the setting of basal levels of membrane potential to shaping action potentials in excitable cells (PAPAZIAN et al. 1987).
O. Pongs, C. Legros
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Voltage-Gated Potassium Channels
Acta Crystallographica Section A Foundations and Advances, 2023openaire +2 more sources
Management of Voltage-Gated Potassium Channel Antibody Disorders
Neurologic Clinics, 2010Syndromes from antibodies to voltage-gated potassium channels include neuromyotonia (NMT), limbic encephalitis (LE) and Morvan syndrome (MVS). There are distinct clinical features for NMT (cramps, stiffness, fasciculations, myokymia, hyperhidrosis; afterdischarges and continuous motor activity on electromyogram), LE (encephalopathy with seizures ...
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The voltage-gated potassium channels and their relatives
Nature, 2002The voltage-gated potassium channels are the prototypical members of a family of membrane signalling proteins. These protein-based machines have pores that pass millions of ions per second across the membrane with astonishing selectivity, and their gates snap open and shut in milliseconds as they sense changes in voltage or ligand concentration.
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Artificial channels for confined mass transport at the sub-nanometre scale
Nature Reviews Materials, 2021Jie Shen, Gong-Ping Liu, Yu Han
exaly