Results 101 to 110 of about 118,788 (309)

Inductor-Based Active Balancing Topology with Wide Voltage Range Capability

Batteries
With the increasing number of batteries integrated into the grid, the electrification of transportation, and the importance of reusing secondary batteries to preserve natural resources, active balancing techniques are becoming critical for optimizing ...
Hourong Song, Branislav Hredzak, John Fletcher   +2 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

A Voltage-Balancer-Based Cascaded DC–DC Converter With a Novel Power Feedforward Control for the Medium-Voltage DC Grid Interface of Photovoltaic Systems

IEEE Access, 2019
DC-DC converters with output-series cascaded submodules (SMs) are required for the medium-voltage direct current (MVDC) grid interface of photovoltaic (PV) systems.
Yizhan Zhuang, Fei Liu, Yanhui Huang, Xiangjing Zhang, Xiaoming Zha   +4 more
doaj   +1 more source

A branch current reallocation based energy balancing strategy for the modular multilevel matrix converter operating around equal frequency [PDF]

, 2016
The Modular multilevel matrix converter (M3C) is a promising topology for medium-voltage, high-power applications. Due to the modular structure, it is scalable, produces high quality output waveforms and can be fault tolerant.
Fan, Boran, Gu, Chunyang, Li, Yongdong, Wang, Kui, Wheeler, Patrick   +4 more
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Cophase Traction Power Supply System Based on Improved MMC-STATCOM-Vv Wiring

IEEE Access
A static synchronous compensator topology with an improved MMC (MMC-STATCOM) is proposed in this study after analyzing the modular converter (MMC) topology.
Yong Zhou, Minan Tang, Weili Liu
doaj   +1 more source

Multi-Objective Predictive Balancing Control of Battery Packs Based on Predictive Current

Energies, 2016
Various balancing topology and control methods have been proposed for the inconsistency problem of battery packs. However, these strategies only focus on a single objective, ignore the mutual interaction among various factors and are only based on the ...
Wenbiao Li, Longyun Kang, Xiangwei Guo, Yuan Yao   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source