Results 61 to 70 of about 21,138 (359)

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

open access: yesFEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Plug replaces weld filler as seal in complex casting [PDF]

open access: yes, 1966
Expandable metal plug is inserted to provide a seal to support the mold core with small blocks, referred to as chaplets, during the casting of a complex volute.
Goundrey, R. L., Harris, C. L.
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Some Unsteady Fluid Forces on Pump Impellers [PDF]

open access: yes, 1992
Spectral analyses of all the forces and moments acting on a typical centrifugal pump impeller/volute combination are presented. These exhibit shaft frequencies, blade passing frequencies, and beat frequencies associated with a whirl motion imposed on ...
Brennen, C. E., Miskovish, R. S.
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

MODERNIZATION OF THE FLOW SECTION OF THE MAIN CIRCULATION PUMP GCN 22600-87

open access: yesИзвестия высших учебных заведений: Проблемы энергетики, 2018
In the presented work, a new version of the design of the flow-through part of the main circulation pump for NPPs with increased energy indices is proposed.
E. A. Ivanov   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Diagnosis of Centrifugal Pump Faults Using Vibration Methods [PDF]

open access: yes, 2012
Pumps are the largest single consumer of power in industry. This means that faulty pumps cause a high rate of energy loss with associated performance degradation, high vibration levels and significant noise radiation.
Al Thobiani, Faisal   +3 more
core   +1 more source

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