Results 51 to 60 of about 4,444,377 (217)
Advanced Science, EarlyView.HECTD1 emerges as an upstream amplifier of Th17 metabolic programming by promoting K63‐linked ubiquitination of IGF2BP3 and enhancing HIF‐1α translation. HIF‐1α reciprocally drives HECTD1 transcription, establishing a positive regulatory loop that sustains glycolysis and Th17 differentiation.
Shuiyu Xu +12 more
wiley +1 more source
Anatomical Sciences Education, EarlyView.Abstract Medical education must balance foundational science with clinical relevance. Increasing emphasis on standardized assessments has led to prioritization of “high‐yield” conditions—those most likely to be assessed. Subsequently, educators and students often prioritize these conditions.
Kathryn Veazey, Oheneba Boadum
wiley +1 more source
Brain Pathology, 1995 After a decade of intensive clinical and molecular genetic efforts the von Hippel‐Lindau (VHL) gene was cloned in 1993. The open reading frame encodes the putative protein of 284 amino acids. A large number of different mutations have been identified so far, including single base mutations, deletions, rearrangements and more complex mutations.
Neumann, Hartmut P. H. +3 more
openaire +3 more sources
Regulatory harmonization: Evolution, globalization and future directions
British Journal of Clinical Pharmacology, EarlyView.Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm +2 more
wiley +1 more source
A Case of Von Hippel Lindau Disease [PDF]
Medical Journal Armed Forces India, 2007 Ayoung recruit presented with weakness of right lower limb, which was diagnosed as a case of Von Hippel Lindau (VHL) disease. It is a rare disease which causes central nervous system and other visceral neoplasm/ cysts.
S, Bhargava, A, Rao, A, Mishra
openaire +2 more sources
von Hippel-Lindau syndrome: analysis of multiple pathologies' connections
, 2023 reservedLa sindrome di von Hippel-Lindau, una rara malattia autosomica dominante, predispone l'individuo alla formazione di patologie multiple di natura sia benigna che maligna. La comprensione delle relazioni tra le diverse patologie manifestate risulta
BOSCOLO ANZOLETTI, AURORA
core
Enfermedad de Von Hippel-Lindau: una presentación atípica [PDF]
, 2004 OBJETIVO: Describir una presentación atípica de la enfermedad de von Hippel-Lindau. MATERIAL Y MÉTODO: Presentamos la clínica, diagnóstico y tratamiento de las manifestaciones urológicas de esta enfermedad, de índole mayormente neurológica, en un varón ...
Murio,E. +9 more
core +1 more source
Bilateral pheochromocytoma as first manifestation of von Hippel-Lindau disease: a case report
The Turkish Journal of Pediatrics, 2012 Von Hippel-Lindau syndrome is an autosomal dominant disorder that includes susceptibility to hemangioblastomas of the eyes and central nervous system, renal clear cell carcinoma, multiple pancreatic cysts, serous cystadenomas and pancreatic ...
Gönül Catli +5 more
doaj
Optimized Coherence Masking Improves Ultrasound Imaging of Kidney Cysts
Journal of Ultrasound in Medicine, EarlyView.Objectives Renal cystic lesions are exceedingly common and typically benign, though accurate diagnostic techniques are required to recognize the subset of malignant lesions that require timely intervention. Ultrasound (US) is the preferred first line test for renal cyst evaluation because it is safe, widely accessible, and low cost. US imaging, however,
Scott Schoen Jr +12 more
wiley +1 more source
Surgical treatment of von Hippel-Lindau disease complicated by retinal detachment: a clinical case
Российский офтальмологический журнал, 2018 A clinical case of surgical treatment of a patient with von Hippel-Lindau disease complicated by retinal detachment is presented. Intravitreal injection of ranibizumab was performed 7 days before vitrectomy.
V. V. Neroev +3 more
doaj +1 more source