Results 61 to 70 of about 4,444,377 (217)
Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research
Mass Spectrometry Reviews, EarlyView.Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik +3 more
wiley +1 more source
Ophthalmological Aspects of von-Hippel-Lindau Syndrome
, 2021 Background: von Hippel-Lindau (VHL) syndrome is a multisystem neoplastic disorder involving eyes, central nervous system, kidneys, spine, and other tissues.
SAATCİ, ALİ OSMAN +21 more
core +1 more source
Cáncer Renal Hereditario Bilateral en Von Hippel Lindau.
Revista Guatemalteca de Urología, 2020 OBJETIVO: Presentar el caso clínico de una paciente con diagnóstico de Cáncer de células claras renales bilateral en su variedad familiar de Von Hippel-Lindau ANTECEDENTES: El cáncer de células renales es el de mayor predominio histológico de las ...
Pablo Le Masson T. +2 more
doaj +1 more source
Keeping It Native: Non‐Denaturing Approaches to Top‐Down Protein Mass Spectrometry
Mass Spectrometry Reviews, EarlyView.ABSTRACT Top‐down proteomics and top‐down mass spectrometry approaches provide direct characterization of proteoforms; the specific molecular forms of proteins, including post‐translational modifications, truncations, alternative splicing, and sequence variants.
Michael Xiao +3 more
wiley +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Targeted elimination of pathogenic proteins remains a fundamental challenge in therapeutic intervention, particularly for proteins considered “undruggable” by conventional inhibition‐based approaches. Aptamer–based targeted protein degradation (TPD) has emerged as a versatile strategy that leverages the high specificity, structural ...
Ambrin Malik +3 more
wiley +1 more source
SHP2 in Cancer: From Tumor Biology to Therapeutic Targeting
Medicinal Research Reviews, EarlyView.ABSTRACT SHP2 is a tyrosine phosphatase that mediates intracellular signaling downstream of transmembrane receptors regulated by a pair of src homology 2 (SH2) domains. Its overexpression and mutation are pivotal in driving tumor progression by influencing various cancer's fundamental characteristics, such as metastasis, DNA repair, angiogenesis ...
Maryam Jama +2 more
wiley +1 more source
Von Hippel-Lindau disease with extramedullary and pancreatic involvement
, 2020 We report a patient with Von Hippel-Lindau disease who presented with an intradural extramedullary hemangioblastoma as a primary manifestation.Revisión por ...
Murillo-Díaz, Giuliana +3 more
core +1 more source
Surgical Case Reports, 2017 Background von Hippel-Lindau disease is a dominantly inherited multi-system syndrome with neoplastic hallmarks. Pancreatic lesions associated with von Hippel-Lindau include serous cystic neoplasms, simple cysts, and neuroendocrine tumors. The combination
Shimpei Maeda +10 more
doaj +1 more source
Neuroprotection, EarlyView.Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang +6 more
wiley +1 more source
VON HIPPEL-LINDAU SYNDROME: ASPECTS OF TREATMENT AND MANAGEMENT. CASE REPORT AND LITERATURE REVIEW
Архивъ внутренней медицины, 2019 The steadily growing interest in studying of endocrine genetics is driven not only by the search for new pathologies but also by the most pressing need to develop methods for early diagnosis, treatment and management of patients.
I. I. Larina +10 more
doaj +1 more source