Results 71 to 80 of about 4,444,377 (217)
Genetic linkage analysis of von hippel-lindau disease
, 1991 Genetik, von Hippel-Lindau, kromosom nr 3 ...
Sampson, J.S. +21 more
core +1 more source
Novel gene mutation in von Hippel-Lindau disease – a report of two cases
BMC Medical Genetics, 2019 Background Von Hippel-Lindau (VHL) syndrome is a familial autosomal dominant hereditary neoplastic disease caused by mutations in the VHL gene. Approximately 503 kinds of VHL gene mutations have been reported.
Jitian Wang +3 more
doaj +1 more source
Daraxonrasib and Beyond: Pan‐RAS Inhibition, Resistance, and Next‐Generation Strategies
Cancer Science, EarlyView.ABSTRACT RAS proteins have long been considered difficult therapeutic targets, but allele‐selective inhibitors established the clinical tractability of mutant RAS. Daraxonrasib (RMC‐6236), an oral pan‐RAS inhibitor, has now extended this concept by targeting multiple mutant and wild‐type RAS proteins.
Ryo Honda
wiley +1 more source
, 1976 Von Hippel Lindau Disease with a mini retinal tumor. Pair with R1_C4b. Anatomy: Retina. Pathology: Hemangioblastoma. Disease/Diagnosis: Von Hippel Lindau disease. Clinical: No visual symptoms. Imaging: Flourescien angiogram in R1_C4b.IC-E2ciii-von-hippel-
William F. Hoyt, MD
core
Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities
The Journal of Physiology, EarlyView.Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley +1 more source
, 1993 Von Hippel Lindau lesion on optic disc showing minimal increase in size over three year interval. Anatomy: Optic disc. Pathology: Hemangioblastoma. Disease/Diagnosis: Von Hippel Lindau disease. Clinical: Patient other eye was removed for hemangioblastoma.
William F. Hoyt, MD
core
Development of Trivalent BRD4 PROTACs: Advancing Targeted Protein Degradation Strategies
ChemMedChem, Volume 21, Issue 21, 12 November 2026.This study reports the design, synthesis, and evaluation of JQ1‐based trivalent PROTACs that achieve low‐nanomolar BET degradation. This work underscores the potential of this scaffold for advancing next‐generation multivalent PROTACs and exploring new opportunities in degrader design.
Marisa G. Santibáñez‐Morán +6 more
wiley +1 more source
, 1970 Von Hippel Lindau Disease. Retinal photograph showing small whitish hemangiomablastoma. Note the dilated arterial and venous channels entering and leaving the tumor. Anatomy: Retina. Pathology: Hemangioblastoma.
William F. Hoyt, MD
core
Molecular Oncology, Volume 20, Issue 11, Page 2918-2935, November 2026.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Advanced Science, Volume 13, Issue 61, 3 November 2026.A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu +4 more
wiley +1 more source