Results 1 to 10 of about 151,232 (337)

Closing the gap – detection of clinically relevant von Willebrand disease in emergency settings through an improved algorithm based on rotational Thromboelastometry

BMC Anesthesiology, 2019
Background Hemorrhage and blood loss are still among the main causes of preventable death. Global hemostatic assays are useful point-of-care test (POCT) devices to rapidly detect cumulative effects of plasma factors and platelets on coagulation ...
H.-G. Topf, E. R. Strasser, G. Breuer, W. Rascher, M. Rauh, F. B. Fahlbusch   +5 more
doaj   +2 more sources

New therapies for von Willebrand disease [PDF]

Blood Advances, 2019
The management of von Willebrand disease (VWD) is based upon the dual correction of the primary hemostasis defect, due to the inherited deficiency of von Willebrand factor (VWF), and of the secondary defect of factor VIII coagulant activity (FVIII:C ...
Pier Mannuccio Mannucci
openalex   +2 more sources

Mechanisms of thrombocytopenia in platelet-type von Willebrand disease

Haematologica, 2019
Platelet-type von Willebrand disease is an inherited platelet disorder characterized by thrombocytopenia with large platelets caused by gain-of-function variants in GP1BA leading to enhanced GPIbα-von Willebrand factor (vWF) interaction.
Loredana Bury, Alessandro Malara, Stefania Momi, Eleonora Petito, Alessandra Balduini, Paolo Gresele   +5 more
doaj   +2 more sources

Individualizing dosing frequency may improve the efficacy of prophylaxis in patients with von Willebrand disease—a WIL-31 subanalysis [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: The efficacy and safety of prophylaxis with wilate, a plasma-derived von Willebrand factor/factor VIII concentrate, was demonstrated in patients with von Willebrand disease of all types in the WIL-31 study.
Robert F. Sidonio, Jr., Ana Boban, Toshko Lissitchkov, Laszlo Nemes, Vladimir Vdovin, Claudia Djambas Khayat   +5 more
doaj   +2 more sources

Diagnosis of von Willebrand disease [PDF]

Blood Advances
: von Willebrand disease (VWD) is the most common inherited bleeding disorder, resulting from a deficiency and/or dysfunction of von Willebrand factor (VWF).
Mackenzie Bowman, Paula James
doaj   +2 more sources

Molecular and clinical profile of von Willebrand disease in Spain (PCM-EVW-ES): comprehensive genetic analysis by next-generation sequencing of 480 patients

Haematologica, 2017
Molecular diagnosis of patients with von Willebrand disease is pending in most populations due to the complexity and high cost of conventional molecular analyses.
Nina Borràs, Javier Batlle, Almudena Pérez-Rodríguez, María Fernanda López-Fernández, Ángela Rodríguez-Trillo, Esther Lourés, Ana Rosa Cid, Santiago Bonanad, Noelia Cabrera, Andrés Moret, Rafael Parra, María Eva Mingot-Castellano, Ignacia Balda, Carme Altisent, Rocío Pérez-Montes, Rosa María Fisac, Gemma Iruín, Sonia Herrero, Inmaculada Soto, Beatriz de Rueda, Víctor Jiménez-Yuste, Nieves Alonso, Dolores Vilariño, Olga Arija, Rosa Campos, María José Paloma, Nuria Bermejo, Rubén Berrueco, José Mateo, Karmele Arribalzaga, Pascual Marco, Ángeles Palomo, Lizheidy Sarmiento, Belén Iñigo, María del Mar Nieto, Rosa Vidal, María Paz Martínez, Reyes Aguinaco, Jesús María César, María Ferreiro, Javier García-Frade, Ana María Rodríguez-Huerta, Jorge Cuesta, Ramón Rodríguez-González, Faustino García-Candel, Rosa Cornudella, Carlos Aguilar, Francisco Vidal, Irene Corrales   +48 more
doaj   +2 more sources

von Willebrand Factor (VWF) Inhibitors in Two Brothers with von Willebrand Disease: A Case Report [PDF]

TH Open
The development of inhibitors to von Willebrand factor (VWF) is a rare but potentially serious complication of VWF replacement therapy in patients with von Willebrand disease (VWD).
Claudia Djambas Khayat, Anna Pavlova, Sylvia Werner, Sigurd Knaub, Robert F. Sidonio   +4 more
doaj   +2 more sources

ASH ISTH NHF WFH 2021 guidelines on the diagnosis of von Willebrand disease.

Blood Advances, 2021
BACKGROUND von Willebrand disease (VWD) is the most common inherited bleeding disorder known in humans. Accurate and timely diagnosis presents numerous challenges.
P. James, Nathan T Connell, B. Ameer, J. Di Paola, Jeroen C J Eikenboom, Nicolas Giraud, S. Haberichter, Vicki Jacobs-Pratt, B. Konkle, C. McLintock, Simon McRae, Robert R Montgomery, J. O’Donnell, Nikole Scappe, R. Sidonio, V. Flood, Nedaa M Husainat, Mohamad A. Kalot, R. Mustafa   +18 more
semanticscholar   +1 more source

ASH ISTH NHF WFH 2021 guidelines on the management of von Willebrand disease.

Blood Advances, 2021
BACKGROUND von Willebrand disease (VWD) is a common inherited bleeding disorder. Significant variability exists in management options offered to patients.
Nathan T Connell, V. Flood, R. Brignardello-Petersen, R. Abdul-Kadir, Alice Arapshian, Susie Couper, Jean M Grow, P. Kouides, M. Laffan, M. Lavin, F. Leebeek, S. O’Brien, M. Ozelo, A. Tosetto, A. Weyand, P. James, Mohamad A. Kalot, Nedaa M Husainat, R. Mustafa   +18 more
semanticscholar   +1 more source

Elevated von Willebrand factor levels during heavy menstrual bleeding episodes limit the diagnostic utility for von Willebrand disease

Research and Practice in Thrombosis and Haemostasis, 2021
Heavy menstrual bleeding (HMB) is often the first bleeding symptom for female individuals with inherited bleeding disorders. Guidelines recommend performing the hemostatic evaluation at HMB presentation.
Megan C Brown, Michael H White, Rachel Friedberg, K. Woods, Krista Childress, Mona Kulkarni, R. Sidonio   +6 more
semanticscholar   +1 more source