Results 101 to 110 of about 147,268 (335)

The relationship between ADAMTS13 genotype and phenotype in congenital thrombotic thrombocytopenic purpura and characterisation of ADAMTS13 mutants

, 2015
Congenital thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy, usually involving ADAMTS13 gene defects. ADAMTS13 processes the multimeric plasma glycoprotein Von Willebrand factor making it less reactive to platelets.
Underwood, MI
core  

Long-term impact of joint bleeds in von Willebrand disease: A nested case-control study [PDF]

, 2017
Patients with severe von Willebrand disease (VWD) may develop arthropathy after joint bleeds. Information on its prevalence and severity is limited. We aimed to assess the occurrence and severity of arthropathy in VWD and its impact on daily life.
Frank W.G. Leebeek, Wouter Foppen, Britta A.P. Laros-van Gorkom, Cnossen, Marjon H., Kathelijn Fischer, Mauser-Bunschoten, Evelien P., van der Bom, Johanna G, Leebeek, Frank W G, Marjon H. Cnossen, Eikenboom, Jeroen H C, Mauser-Bunschoten, Eveline P., Joke de Meris, Karina Meijer, Laros-van Gorkom, Britta A P, Karin Fijnvandraat, Cnossen, Marjon H, Roger E.G. Schutgens, van Galen, Karin P. M., van der Bom, Johanna G., Meijer, Karina; id_orcid, Fijnvandraat, Karin, Jeroen Eikenboom, Foppen, Wouter, Johanna G. van der Bom, de Meris, Joke, Eveline P. Mauser-Bunschoten, de Kleijn, Piet, Meijer, Karina, van Galen, Karin P.M., Laros-van Gorkom, Britta A. P., Piet de Kleijn, Schutgens, Roger E. G., Fischer, Kathelijn, Schutgens, Roger E.G., WiN Study Group, Eikenboom, Jeroen, Leebeek, Frank W. G., Karin P.M. van Galen   +37 more
core   +1 more source

Biomarkers of endothelial activation/dysfunction in infectious diseases

Virulence, 2013
Endothelial dysfunction contributes to the pathogenesis of a variety of potentially serious infectious diseases and syndromes, including sepsis and septic shock, hemolytic-uremic syndrome, severe malaria, and dengue hemorrhagic fever. Because endothelial
A. Page, W. Liles
semanticscholar   +1 more source

Kaposiform hemangioendothelioma: Diagnosis and treatment

Pediatric Investigation, EarlyView.
Vascular endothelial growth factor‐C (VEGF‐C)/vascular endothelial growth factor receptor‐3 (VEGFR‐3) and angiopoietin‐2 (Ang‐2)/tyrosine kinase with immunoglobulin‐like and EGF‐like domain 2 (TIE2) signaling pathways play an important role in lymphangiogenesis.
Yi Tian, Yuanyuan Tian, Li Wei, Zigang Xu, Li Li, Lin Ma   +5 more
wiley   +1 more source

Acquired von Willebrand disease associated with smoldering multiple myeloma and hereditary hemorrhagic telangiectasia successfully treated with daratumumab, pomalidomide, and dexamethasone: hitting three birds with one stone? – case report

Frontiers in Hematology
Acquired von Willebrand disease (AvWD) is a rare bleeding disorder that results from a structural or functional defect of von Willebrand factor.
Lemchukwu Amaeshi, Jacqueline N. Poston, Jacqueline N. Poston, Mansour Gergi   +3 more
doaj   +1 more source

De ziekte van von Willebrand in Nederland: de WiN-studie

, 2014
Von Willebrand disease is the most common inherited bleeding disorder and is characterised by mucocutaneous bleeding. Von Willebrand disease is caused by reduced levels or reduced function of von Willebrand factor.
Fijnvandraat, C. J. Karin, Cnossen, Marjon H., Sanders, Yvonne V., Meijer, Karina, Mauser-Bunschoten, Evelien P., Laros-van Gorkom, Britta A. P., Eikenboom, J., Leebeek, Frank W. G., de Wee, Eva M., van der Bom, Jeroen G.   +9 more
core  

Biomarkers to predict outcomes in diabetic foot ulcers

VIEW, EarlyView.
Studies attempting to predict the healing outcome of diabetic foot ulcers (DFUs) have investigated various biological materials and recovered molecules that may aid in discriminating wounds that will heal and those that will not heal. This graphical abstract captures the commonly studied classes of biomarkers in the context of DFUs.
Julie Okiro, Kellie Fortune, Eimear Daly, Luca McCann, Merhan Soltan, Seamus Sreenan, Fabio Quondamatteo   +6 more
wiley   +1 more source

The molecular linkage of von Willebrand Factor (VWF) and pathological coagulation in disease [PDF]

This thesis describes the assessment of the alterations in von Willebrand factor (VWF) levels, as well as its activation status in various diseases and the evaluation of the interaction between VWF and platelets, the inflammatory response and thrombin ...
Huang, Shengshi
core   +1 more source

Elevated plasma von Willebrand factor and propeptide levels in Malawian children with malaria. [PDF]

, 2011
In spite of the significant mortality associated with Plasmodium falciparum infection, the mechanisms underlying severe disease remain poorly understood.
Malcolm E. Molyneux, Craig, Alister G., de Laat, Bas, Seydel, Karl B., Simon J Glover, Alister G Craig, Taylor, Terrie E., Daniel J Bridges, Bas de Laat, Jan A. van Mourik, Molyneux Malcolm E., Taylor Terrie E., Happy T Phiri, E Brian Faragher, M'baya Bridon, Daniel J. Bridges, Glover Simon J., James E G Bunn, Faragher E. Brian, Craig Alister G., Jan A van Mourik, M'baya, Bridon, Glover, Simon J., Bunn James E. G., Karl B. Seydel, Bridges, Daniel J., van Mourik Jan A., James E. G. Bunn, Bridges Daniel J., Karl B Seydel, van Mourik, Jan A., Molyneux, Malcolm E., Terrie E. Taylor, Malcolm E Molyneux, Phiri, Happy T., Happy T. Phiri, Bunn, James E.G., Bunn, James E. G., Phiri Happy T., de Laat Bas, Terrie E Taylor, Faragher, E. Brian, Seydel Karl B., Alister G. Craig, Bridon M'baya, Simon J. Glover, E. Brian Faragher, Craig, Alister   +47 more
core   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source