Results 101 to 110 of about 6,412,465 (299)

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Clinical utility of panel-based genetic sequencing for von Willebrand disease

Research and Practice in Thrombosis and Haemostasis
Background: von Willebrand disease (VWD) is the most prevalent inherited bleeding disorder with a wide spectrum of causative variants. Next-generation sequencing analyzes the entire VWF gene and provides concomitant assessment of other genes, allowing ...
Radha Ramanan, Christine Van Laer, Sarissa Baert, Cyrielle Kint, Chris Van Geet, Quentin Van Thillo, Peter Verhamme, Thomas Vanassche, James D. McFadyen, Andrew C. Perkins, Huyen A. Tran, Veerle Labarque, Kathleen Freson   +12 more
doaj   +1 more source

Safety of Recombinant von Willebrand Factor in the Treatment of von Willebrand Disease: Real-World Data from an EU Post-Authorization Safety Study [PDF]

Susan M Sinclair, Yi Ba, Kayode Badejo Takeda Development Center Americas, Inc., Cambridge, MA, USACorrespondence: Susan M Sinclair, Takeda Development Center Americas, Inc., 650 E Kendall Street, Cambridge, MA, 02142, USA, Email susan.sinclair@takeda ...
Sinclair SM, Ba Y, Badejo K
core  

Four‐dimensional immuno‐mechanobiomaterials: Dynamic material cues that program host response to prevent fibrosis and enable regeneration

VIEW, EarlyView.
Dynamic immuno‐mechanobiomaterials with time‐programmed mechanical adaptation orchestrate host responses through precise mechanotransduction and immune‐stromal regulation. These adaptive biomaterials minimize mechanical mismatch, attenuate the forign dy response and fibrosis, promote angiogenesis and controlled extracellular matrix remodeling, and ...
Gobinath Vellapalayam Manoharan, Kathirvel Ayyaswamy, Parthasarathy Vellaichamy, Nagarajan Deivanayagam Pillai, Rithik Gobinath   +4 more
wiley   +1 more source

Deficiency of high‐molecular‐weight von Willebrand factor mitigates thrombo‐complement injury in an LPS‐induced TMA‐like mouse model

VIEW, EarlyView.
Reduction of high‐molecular‐weight von Willebrand factor disrupts the platelet–complement amplification loop, attenuating microvascular thrombosis, complement deposition, endothelial injury, and organ damage in complement‐mediated thrombotic microangiopathy.
Yang Li, Chihao Zhang, Xiaoqian Xu, Sicong Wang, Xiaofan Hu, Junjie Yao, Xi Wu, Difeng Zhu, Qian Liang, Yeling Lu, Yu Liu, Guanqun Xu, Jiakuan Zhou, Qiulan Ding, Wenman Wu, Ya Li, Jing Dai, Xuefeng Wang   +17 more
wiley   +1 more source

Clinical and Laboratory Characterization of Acquired Von Willebrand Syndrome. [PDF]

Am J Hematol
ABSTRACT Acquired von Willebrand Syndrome (AVWS) is a rare bleeding disorder characterized by quantitative or qualitative defects of von Willebrand factor (VWF) in patients without a personal or family history of bleeding. It is frequently associated with systemic diseases, particularly lymphoproliferative disorders (LPDs) and myeloproliferative ...
Ciavarella A, Baronciani L, Seidizadeh O, Colpani P, Ingenito E, Cattaneo D, Pagliari MT, Truma A, Iurlo A, Siboni SM, Peyvandi F.   +10 more
europepmc   +2 more sources

An Automated Microfluidic System for Haemostasis Assessment in Cirrhosis With Thrombocytopenia. [PDF]

Liver Int
ABSTRACT Background & Aims Conventional laboratory tests do not capture platelet–vessel wall interactions (primary haemostasis) occurring in vivo, limiting guidance before invasive procedures. This is relevant in patients with thrombocytopenia, hallmark of advanced cirrhosis. Microfluidic assays may overcome these limitations.
Bitto N, Tosetti G, Tripodi A, Lecchi A, La Marca S, Padovan L, Scalambrino E, Clerici M, Caputo C, Lucà M, Primignani M, Fracanzani AL, Lampertico P, Peyvandi F, La Mura V.   +14 more
europepmc   +2 more sources

International Practice Variation in Post‐Tonsillectomy Hemorrhage: A Survey Study of Pediatric Otolaryngologists

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background A significant complication of pediatric tonsillectomy is post‐tonsillectomy bleeding (PTB). Management within and outside of the operating room (OR) is not standardized. We consolidated international similarities and differences in PTB management.
Gina M. Spencer, Claire A. Wilson, Jacob Davidson, Julie E. Strychowsky, Claire M. Lawlor, Hannah Burns, Eishaan K. Bhargava, James Fowler, M. Elise Graham   +8 more
wiley   +1 more source

Persistent Gingival Bleeding After Scaling: A Diagnostic Clue to von Willebrand Disease. [PDF]

Clin Case Rep
ABSTRACT Von Willebrand disease (VWD) is not a rare inherited bleeding disorder. However, it is frequently underdiagnosed because early mucocutaneous bleeding manifestations are often attributed to local factors such as inflammation or anatomical abnormalities, leading to delayed recognition of the underlying systemic disease. A 31‐year‐old Han Chinese
Zhang H, Qiu N, Cao Z, Shang S.
europepmc   +2 more sources

De ziekte van von Willebrand in Nederland: de WiN-studie

, 2014
Von Willebrand disease is the most common inherited bleeding disorder and is characterised by mucocutaneous bleeding. Von Willebrand disease is caused by reduced levels or reduced function of von Willebrand factor.
Fijnvandraat, C. J. Karin, Cnossen, Marjon H., Sanders, Yvonne V., Meijer, Karina, Mauser-Bunschoten, Evelien P., Laros-van Gorkom, Britta A. P., Eikenboom, J., Leebeek, Frank W. G., de Wee, Eva M., van der Bom, Jeroen G.   +9 more
core