Results 121 to 130 of about 147,268 (335)
The effect of DDAVP infusion On thrombin generation in platelet-rich plasma of von Willebrand type 1 and in mild haemophilia A patients [PDF]
, 2000 SummaryIn von Willebrand disease (vWD) type 1 and mild haemophilia A patients we studied the effect of an infusion of DDAVP (0.3 ?g/kg body weight) on thrombin generation in platelet-rich plasma (PRP) and platelet-poor plasma (PPP).
Béguin, S. +7 more
core +1 more source
Andrology, EarlyView.ABSTRACT Background Cell therapy, particularly those utilizing mesenchymal stem/stromal cells (MSCs), is gaining traction as a therapeutic option for regenerative treatment in patients with limited therapeutic options. Although the safety of MSC‐based interventions is well established, uncertainties remain regarding how genetic abnormalities and ...
Marzena Zychowicz +12 more
wiley +1 more source
Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2022 Objective: To compare the status of oral hygiene and dentition in patients with congenital hemorrhagic disorders with their age-matched healthy counterparts.
Mathangi Kumar +3 more
doaj
Artificial Organs, EarlyView.This study aims to evaluate the potential of a multistage pump design to enhance hemocompatibility in left ventricular assist devices. We found that the two‐stage concept offers favorable hemolysis measures compared to single‐stage designs, as the reduction in peak shear stresses outweighs the disadvantage associated with prolonged residence time ...
Sarah Linnemeier +6 more
wiley +1 more source
Hemodynamic activation of von Willebrand factor in children with congenital heart diseases
Акушерство, гинекология и репродукцияQuite complex and non-linear cellular and molecular mechanisms underlie hemostasis changes in patients with congenital heart diseases (CHD). Altered activity ratio between von Willebrand factor (vWF) and metalloproteinase ADAMTS-13 (a disintegrin and ...
K. A. Tokmakova +2 more
doaj +1 more source
Enfermedad de Von Willebrand, tipos, estrategias, diagnóstico y opciones terapéuticas
, 2021 Von Willebrand disease is the most common congenital hemorrhagic diathesis that affects up to 1% of the world`s population. It affects both men and women.
Ponce Pincay, Yelena Katiusca +2 more
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Artificial Organs, EarlyView.Shear‐induced blood damage—including hemolysis, platelet and neutrophil injury, and von Willebrand factor (vWF) degradation—was evaluated for the BrioVAD and HM3 using an in vitro circulatory loop under clinically relevant conditions. Across 15 biomarkers (n > 6 per group), no significant differences were observed between the two devices.
Wenji Sun +9 more
wiley +1 more source
Clinical utility of panel-based genetic sequencing for von Willebrand disease
Research and Practice in Thrombosis and HaemostasisBackground: von Willebrand disease (VWD) is the most prevalent inherited bleeding disorder with a wide spectrum of causative variants. Next-generation sequencing analyzes the entire VWF gene and provides concomitant assessment of other genes, allowing ...
Radha Ramanan +12 more
doaj +1 more source
A first description of the Colombian national registry for rare diseases
BMC Research Notes, 2017 Objective Orphan diseases must be considered a public health concern, underlying country-specific challenges for their accurate and opportune diagnosis, classification and management.
Heidi Eliana Mateus +7 more
doaj +1 more source
, 2003 BACKGROUND: Nucleotide variations not changing protein sequences are considered silent mutations; accumulating data suggest that they can, however, be important in human diseases.
PONTARA, ELENA +5 more
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