Results 111 to 120 of about 192,512 (365)
The Journal of Clinical Pharmacology, EarlyView.Abstract Efanesoctocog alfa is a first‐in‐class high‐sustained factor VIII (HSF) replacement therapy for treatment of hemophilia A. This article presents population pharmacokinetics (PopPK) of efanesoctocog alfa and repeated time‐to‐event (RTTE) analysis of bleeding episodes in adults/adolescents (≥12 years of age) and children (<12 years).
Nancy Wong +7 more
wiley +1 more source
Conformational dynamics of charged polymers interacting with charged nanoparticles [PDF]
arXiv, 2018 The transition from globular to elongated states of biopolymers in shear flow occurs at a distinct critical shear rate, $\dot{\gamma }^{*}$. The magnitude of $\dot{\gamma }^{*}$ depends on the internal potential and the polymer length. For example, the critical shear is much larger for von Willebrand Factor (vWF) compared to DNA.
arxiv
Statistical dynamics of social distancing in SARS-CoV-2 as a differential game [PDF]
arXiv, 2020 The novel coronavirus SARS-CoV-2 has rapidly emerged as a significant threat to global public health, in particular because -- as is not uncommon with novel pathogens -- there is no effective pharmaceutical treatment or prophylaxis to the viral syndrome it causes.
arxiv
Vascular risk factors and diabetic neuropathy [PDF]
, 2005 Background: Other than glycemic control, there are no treatments for diabetic neuropathy. Thus, identifying potentially modifiable risk factors for neuropathy is crucial.
Chaturvedi, N. +7 more
core +1 more source
Biomarkers of endothelial activation/dysfunction in infectious diseases
Virulence, 2013 Endothelial dysfunction contributes to the pathogenesis of a variety of potentially serious infectious diseases and syndromes, including sepsis and septic shock, hemolytic-uremic syndrome, severe malaria, and dengue hemorrhagic fever. Because endothelial
A. Page, W. Liles
semanticscholar +1 more source
BMP signalling in colorectal cancer: losing the yin to WNTs yang
The Journal of Pathology, EarlyView.Abstract Colorectal cancer (CRC) is the third most common form of cancer globally, and arises from the hyperproliferation of epithelial cells in the intestine. The architecture and maintenance of these cells is governed by two major signalling pathways working in a counter‐gradient: the stem cell WNT signalling pathway, and the prodifferentiation bone ...
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Neutrophil extracellular trap (NET) impact on deep vein thrombosis.
Arteriosclerosis, Thrombosis and Vascular Biology, 2012 Deep vein thrombosis (DVT) is a major health problem that requires improved prophylaxis and treatment. Inflammatory conditions such as infection, cancer, and autoimmune diseases are risk factors for DVT.
Tobias A. Fuchs, A. Brill, D. Wagner
semanticscholar +1 more source
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Target‐mediated drug disposition (TMDD) is often associated with high‐affinity binding to a target resulting in nonlinear pharmacokinetics. For large molecules, such as monoclonal antibodies, this can lead to increased clearance at sub‐saturating concentrations.
Ronny Straube
wiley +1 more source
Folding of Pig Gastric Mucin Non-glycosylated Domains: A Discrete Molecular Dynamics Study [PDF]
arXiv, 2009 Mucin glycoprotein consist of tandem repeating glycosylated regions flanked by non-repetitive protein domains with little glycosylation. These non-repetitive domains are involved in the pH dependent gelation of gastric mucin, which is essential to protecting the stomach from autodigestion.
arxiv
ESC Heart Failure, Volume 12, Issue 2, Page 1514-1522, April 2025.
Takamasa Iwai +4 more
wiley +1 more source