Results 11 to 20 of about 192,512 (365)
Неврология, нейропсихиатрия, психосоматика, 2021 Endothelial dysfunction is a universal pathological mechanism underlying or contributing to the development/progression of many diseases, including cerebrovascular disease and multiple sclerosis.
I. A. Koltsov +5 more
doaj +1 more source
Pediatrics In Review, 2014 1. Stacy Cooper, MD 2. Clifford Takemoto, MD 1. Charlotte Bloomberg Children’s Center, Johns Hopkins Hospital Baltimore, MD 1. 1. Nichols W, 2. Hultin MB, 3. James AH, 4. et al Von Willebrand Disease (VWD): Evidence-Based Diagnosis and Management Guidelines, The National Heart, Lung, and Blood Institute (NHLBI) Expert
Stacy Cooper, Clifford M. Takemoto
+8 more sources
Genetics in Medicine, 2011 von Willebrand disease is a common inherited bleeding disorder characterized by excessive mucocutaneous bleeding. Characteristic bleeding symptoms include epistaxis, easy bruising, oral cavity bleeding, menorrhagia, bleeding after dental extraction, surgery, and/or childbirth, and in severe cases, bleeding into joints and soft tissues.
Paula D. James, Anne Goodeve
openaire +5 more sources
Mechanical Forces Impacting Cleavage of Von Willebrand Factor in Laminar and Turbulent Blood Flow
Fluids, 2021 Von Willebrand factor (VWF) is a large multimeric hemostatic protein. VWF is critical in arresting platelets in regions of high shear stress found in blood circulation. Excessive cleavage of VWF that leads to reduced VWF multimer size in plasma can cause
Alireza Sharifi, David Bark
doaj +1 more source
A continuum model for the unfolding of von Willebrand Factor [PDF]
, 2021 von Willebrand Factor is a mechano-sensitive protein circulating in blood that mediates platelet adhesion to subendothelial collagen and platelet aggregation at high shear rates. Its hemostatic function and thrombogenic effect, as well as susceptibility to enzymatic cleavage, are regulated by a conformational change from a collapsed globular state to a
arxiv +1 more source
von Willebrand Factor unfolding mediates platelet deposition in a model of high-shear thrombosis [PDF]
, 2022 Thrombosis under high-shear conditions is mediated by the mechanosensitive blood glycoprotein von Willebrand Factor (vWF). vWF unfolds in response to strong flow gradients and facilitates rapid recruitment of platelets in flowing blood. While the thrombogenic effect of vWF is well recognized, its conformational response in complex flows has largely ...
arxiv +1 more source
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
Polish Journal of Pathology, 2020 Acquired von Willebrand syndrome (AVWS) is a rare bleeding disorder that is associated with a variety of underlying diseases. We report a case of AVWS associated with plasma cell myeloma.
Maria Chraszczewska +4 more
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Prognostic value of von Willebrand factor in clinical practice
Акушерство, гинекология и репродукция, 2022 The von Willebrand factor (vWF) is a multimeric plasma glycoprotein, which quantification has important prognostic value. The current literature review demonstrates a relationship between the disease severity and vWF level.
K. N. Grigoreva +12 more
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, 2017 Von Willebrand Disease (VWD) is a blood clotting disorder characterized by low levels of the Von Willebrand Factor (VWF) in the blood. VWF is functions to bind platelets and promote clotting of the blood when vascular injury occurs.
Misla David, Ramon
core +2 more sources