On the Versatility of von Willebrand Factor
Von Willebrand factor (VWF) is a large multimeric protein, the function of which has been demonstrated to be pivotal to the haemostatic system. Indeed, quantitative and/or qualitative abnormalities of VWF are associated with the bleeding disorder Von ...
A. Rauch+5 more
semanticscholar +1 more source
Reciprocal interactions between tumor and endothelial cells: Effects of selective vasopressin V2 receptor peptide agonists [PDF]
Recent experimental evidence suggested that the synthetic peptide desmopressin (DDAVP) interferes tumor angiogenesis by inducing the formation of angiostatin.
Alonso, Daniel Fernando, Garona, Juan
core +1 more source
High Glucose, But Not Testosterone, Increases Platelet Aggregation Mediated by Endothelial Cells [PDF]
Endothelial cells inhibit platelet aggregation by releasing thromboregulators, such as prostacyclin and nitric oxide. Male subject is a traditional risk factor for cardiovascular diseases.
Aswin, S. (Soedjono)+3 more
core +2 more sources
Background Thrombocytopenia, bleeding and plasma leakage are cardinal features of severe dengue. Endothelial cell activation with exocytosis of Weibel-Palade bodies (WPBs) may play an etiological role in this condition.
K. Djamiatun+8 more
semanticscholar +1 more source
Herbert Gritsch,1 Gerald Schrenk,1 Nina Weinhappl,1 Björn Mellgård,2 Bruce Ewenstein,2 Peter L Turecek3,4 1Pharmaceutical Sciences, Baxalta Innovations GmbH, a Takeda Company, Vienna, Austria; 2Rare Genetics and Hematology, Research & Development, Takeda
Gritsch H+5 more
doaj
Correlation of intracardiac hemodynamics indicators with von Willebrand factor – Marker of endothelial dysfunction in patients with coronary artery disease combined with coronavirus disease (COVID-19) [PDF]
The research relevance is predefined by the need to establish the relationship and identify new markers and potential contributions to clinical practice and scientific progress.
V. Netiazhenko, S. Mostovyi, O. Safonova
doaj +3 more sources
Aptamer-based applications for cardiovascular disease
Cardiovascular disease (especially atherosclerosis) is a major cause of death worldwide, and novel diagnostic tools and treatments for this disease are urgently needed. Aptamers are single-stranded oligonucleotides that specifically recognize and bind to
Xinyuan Chen, Yue Ma, Yuquan Xie, Jun Pu
doaj +1 more source
Migraine and vascular disease biomarkers: A population-based case-control study. [PDF]
Background The underpinnings of the migraine-stroke association remain uncertain, but endothelial activation is a potential mechanism. We evaluated the association of migraine and vascular disease biomarkers in a community-based population.
Ferrari, Michel D.+9 more
core +2 more sources
Clinical surveillance of thrombotic microangiopathies in Scotland, 2003-2005 [PDF]
The prevalence, incidence and outcomes of haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopaenic purpura (TTP) are not well established in adults or children from prospective studies. We sought to identify both outcomes and current management
D. YOUNG+8 more
core +2 more sources
Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses [PDF]
<p>Background: Activation of blood coagulation and fibrinolysis may be associated with increased risk of coronary heart disease. We aimed to assess associations of circulating tissue plasminogen activator (t-PA) antigen, D-dimer and von Willebrand ...
Aspelund, T.+7 more
core +6 more sources