Results 51 to 60 of about 6,412,465 (299)
Animal stroke models and outcome evaluation: A review
Animal Models and Experimental Medicine, EarlyView.Rodents are the preeminent stroke model species. Large animal models exist too, but are poorly standardized. Ischemic and hemorrhagic experimental models are available, with the intraluminal filament model being predominant. Outcomes are evaluated via quantifying subjects' sensorimotor impairment, cognitive memory faculties, degree of cellular ...
Solsa Cariba +2 more
wiley +1 more source
Enfermedad de Von Willebrand: Tipo III, una revisión de la literatura
, 2023 Von Willebrand's disease is characteristic for its clinical manifestations caused by the alteration of the quantity or structural morphology of the von Willebrand factor, in type 3 there is an almost total quantitative absence of vWF, the objective of ...
Yessenia Magaly Cruz Castillo +3 more
core +1 more source
Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke
Annals of Neurology, EarlyView.Objectives Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) is frequent, but its causes remain elusive. We investigated whether biologically relevant intrathrombus concentrations of tissue plasminogen activator (tPA) were achieved in failed IVT and whether neutrophil extracellular traps (NETs) contributed to this therapeutic ...
Mialitiana Solo Nomenjanahary +21 more
wiley +1 more source
Лечащий Врач, 2021 Derangements of hemostatic system after cardiac surgery with cardiopulmonary bypass are described in detail, but predictors of thrombotic complication in this group of children are still not detected.
V. A. Lastovka +3 more
doaj
The relationship between ADAMTS13 genotype and phenotype in congenital thrombotic thrombocytopenic purpura and characterisation of ADAMTS13 mutants [PDF]
, 2015 Congenital thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy, usually involving ADAMTS13 gene defects. ADAMTS13 processes the multimeric plasma glycoprotein Von Willebrand factor making it less reactive to platelets.
Underwood, MI
core
Arthritis &Rheumatology, EarlyView.Objective Systemic lupus erythematosus (SLE) shows clinical and molecular heterogeneity, and cardiovascular (CV) complications and lupus nephritis (LN) remain leading causes of morbidity and mortality. This study investigated whether omic profiling can reveal molecular endotypes linked to these outcomes.
Tomás Cerdó +84 more
wiley +1 more source
BMEMat, EarlyView.The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang +6 more
wiley +1 more source
Endothelial dysfunction in the cardiovascular disease puzzle [PDF]
Medicinski Glasnik, 2009 Endothelial dysfunction (ED) is a syndrome characterized by impairment of endothelium dependent vasodilatation,altered anticoagulant, anti-inflammatory and vascular remodeling properties.
Melanija Ražov Radas +5 more
doaj
Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration
BMEMat, EarlyView.The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang +13 more
wiley +1 more source
Characterization of large in-frame von Willebrand factor deletions highlights differing pathogenic mechanisms [PDF]
, 2020 Copy number variation (CNV) is known to cause all von Willebrand disease (VWD) types, although the associated pathogenic mechanisms involved have not been extensively studied.
Jong, A. de +15 more
core +1 more source