Results 71 to 80 of about 147,268 (335)

Assessment of the dynamics of the fibrin monomer and von Willebrand factor in the postoperative period in children with congenital heart disease

Лечащий Врач, 2021
Derangements of hemostatic system after cardiac surgery with cardiopulmonary bypass are described in detail, but predictors of thrombotic complication in this group of children are still not detected.
V. A. Lastovka, O. B. Gordeeva, R. F. Tepaev, A. R. Bidzhiev   +3 more
doaj  

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Clinical and Laboratory Characterization of Acquired Von Willebrand Syndrome

American Journal of Hematology, EarlyView.
ABSTRACT Acquired von Willebrand Syndrome (AVWS) is a rare bleeding disorder characterized by quantitative or qualitative defects of von Willebrand factor (VWF) in patients without a personal or family history of bleeding. It is frequently associated with systemic diseases, particularly lymphoproliferative disorders (LPDs) and myeloproliferative ...
Alessandro Ciavarella, Luciano Baronciani, Omid Seidizadeh, Paola Colpani, Elio Ingenito, Daniele Cattaneo, Maria Teresa Pagliari, Addolorata Truma, Alessandra Iurlo, Simona Maria Siboni, Flora Peyvandi   +10 more
wiley   +1 more source

Biomimetic Nanoparticle Delivering Colchicine to Target Endothelial Inflammation for Atherosclerosis Treatment

Advanced NanoBiomed Research, EarlyView.
Platelet membrane‐coated layered double hydroxide nanoparticles were engineered to target inflamed endothelium at early‐stage atherosclerosis and enhance therapeutic efficacy. The biomimetic platform improves stability, immune escape, and inflamed vascular cell targeting, resulting in reduced oxidative stress and downregulated adhesion molecules.
Xiuwen Zhang, Lingqing Zong, Ashish Misra, Sanjay Patel, Zi Gu   +4 more
wiley   +1 more source

Porcine and Canine von Willebrand Factor and von Willebrand Disease: Hemostasis, Thrombosis, and Atherosclerosis Studies [PDF]

, 2010
Use of animal models of inherited and induced von Willebrand factor (VWF) deficiency continues to advance the knowledge of VWF-related diseases: von Willebrand disease (VWD), thrombotic thrombocytopenic purpura (TTP), and coronary artery thrombosis ...
Natalie DeFriess, Timothy C. Nichols, Elizabeth P. Merricks, Robin A. Raymer, Dwight A. Bellinger, Thomas R. Griggs, Margaret V. Ragni, Mark T. Kloos   +7 more
core   +1 more source

Unveiling Endotypes in Systemic Lupus Erythematosus Through Multiomic Analysis: Insights Into Cardiovascular and Renal Complications

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) shows clinical and molecular heterogeneity, and cardiovascular (CV) complications and lupus nephritis (LN) remain leading causes of morbidity and mortality. This study investigated whether omic profiling can reveal molecular endotypes linked to these outcomes.
Tomás Cerdó, Laurel Woodridge, Sagrario Corrales, Juan Rafael Muñoz‐Castañeda, Ana Isabel Torralbo, Anisur Rahman, Filipa Farinha, Rafaela Ortega Castro, Pedro Segui, Ismael Sanchez‐Pareja, Laura Muñoz‐Barrera, Christian Merlo, Desiree Ruiz‐Vilchez, M. Carmen Ábalos‐Aguilera, Pilar Font, Nuria Barbarroja Puerto, PRECISESADS Clinical Consortium, Lorenzo Beretta, Barbara Vigone, Jacques‐Olivier Pers, Alain Saraux, Valérie Devauchelle‐Pensec, Divi Cornec, Sandrine Jousse‐Joulin, Bernard Lauwerys, Julie Ducreux, Anne‐Lise Maudoux, Carlos Vasconcelos, Ana Tavares, Esmeralda Neves, Raquel Faria, Mariana Brandão, Ana Campar, António Marinho, Fátima Farinha, Isabel Almeida, Miguel Angel Gonzalez‐Gay Mantecón, Ricardo Blanco Alonso, Alfonso Corrales Martínez, Ricard Cervera, Ignasi Rodríguez‐Pintó, Gerard Espinosa, Rik Lories, Ellen De Langhe, Nicolas Hunzelmann, Doreen Belz, Torsten Witte, Niklas Baerlecken, Georg Stummvoll, Michael Zauner, Michaela Lehner, Eduardo Collantes, Ma Carmen Castro‐Villegas, Norberto Ortego, María Concepción Fernández Roldán, Enrique Raya, Inmaculada Jiménez Moleón, Enrique de Ramon, Isabel Díaz Quintero, Pier Luigi Meroni, Maria Gerosa, Tommaso Schioppo, Carolina Artusi, Carlo Chizzolini, Aleksandra Zuber, Donatienne Wynar, Laszló Kovács, Attila Balog, Magdolna Deák, Márta Bocskai, Sonja Dulic, Gabriella Kádár, Falk Hiepe, Velia Gerl, Silvia Thiel, Manuel Rodriguez Maresca, Antonio López‐Berrio, Rocío Aguilar‐Quesada, Héctor Navarro‐Linares, Marta Alarcón‐Riquelme, Alejandro Escudero‐Contreras, M. Ángeles Aguirre‐Zamorano, Carlos Perez‐Sanchez, Elizabeth C. Jury, Chary Lopez‐Pedrera   +84 more
wiley   +1 more source

Endothelial dysfunction in the cardiovascular disease puzzle [PDF]

Medicinski Glasnik, 2009
Endothelial dysfunction (ED) is a syndrome characterized by impairment of endothelium dependent vasodilatation,altered anticoagulant, anti-inflammatory and vascular remodeling properties.
Melanija Ražov Radas, Viktor Peršić, Alexandra Iskra Nola, Bojan Miletić, Alen Ružić, Aleksandar Včev   +5 more
doaj  

Design Space Assessment of Virus Inactivation in Plasma‐Derived Matrices Establishes a Single Detergent Alternative to TX‐100‐Containing Mixes

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The detergent Triton X‐100 (TX‐100) is a typical component of solvent/detergent (S/D) mixes applied for virus inactivation steps of biomanufacturing processes, yet environmentally unfavorable properties have led to restrictions on its use. Deviron 13‐S9 has recently been described as an eco‐friendly TX‐100 alternative, with powerful virus ...
Johanna Kindermann, Cecilie Klausen, Michael Karbiener, Thomas R. Kreil   +3 more
wiley   +1 more source

Clinical Application and Evaluation of Preoperative Bleeding Tendency using Platelet Function Analyzer (PFA)-100. [PDF]

Archives of Aesthetic Plastic Surgery, 2013
Routine preoperative tests such as BT/CT, PT/PTT and CBC, could not test abnormal hemostasis that take drugs and health functional food. We used platelet function analyzer (PFA®)-100, to evaluate preoperative bleeding tendencies.
Jihu Han, Eon Rok Do, Tae Seob Kim, Chen Zhang, Dae Hwan Park   +4 more
doaj   +1 more source

Joint surgery in von Willebrand disease: a multicentre cross-sectional study [PDF]

, 2016
Background: Joint bleeds are reported by 23% of von Willebrand disease (VWD) patients and associated with orthopaedic surgery. Limited data are available on joint surgery in VWD. Aim: To assess the prevalence, indications, management and complications of
Schutgens, R. E. G., Vogely, H. C., Meijer, K., Schutgens, R. E.G., Eikenboom, J, Laros-van Gorkom, B. A. P., Bom, J.G. van der, Laros-Van Gorkom, BAP, H. C. Vogely, van Galen, K. P.M., Schutgens, REG, K. P. M. van Galen, Leebeek, F. W.G., Galen, K.P.M. van, F. W. G. Leebeek, B. A. P. Laros‐van Gorkom, Leebeek, F.W.G., van Galen, KPM, K. Meijer, Fijnvandraat, K, van der Bom, JG, Fijnvandraat, K., van der Bom, J. G., Schutgens, R.E.G., R. E. G. Schutgens, E. P. Mauser‐Bunschoten, Eikenboom, J., K. Fijnvandraat, J. Eikenboom, Vogely, H.C., Leebeek, F. W. G., Leebeek, Frank, Laros-van Gorkom, B.A.P., Win Study Grp, van Galen, K. P. M., Mauser-Bunschoten, EP, J. G. van der Bom, Cnossen, M. H., M. H. Cnossen, Laros-van Gorkom, B. A.P., Mauser-Bunschoten, E. P., Cnossen, M.H., Cnossen, Marjon, Meijer, K (Karina), Mauser-Bunschoten, E.P., Meijer, K.; id_orcid, WiN Study Group, Vogely, HC, Leebeek, Frank; id_orcid   +48 more
core   +1 more source