Results 71 to 80 of about 6,412,465 (299)

Differential cargo mobilisation within Weibel-Palade bodies after transient fusion with the plasma membrane. [PDF]

, 2014
Inflammatory chemokines can be selectively released from Weibel-Palade bodies (WPBs) during kiss-and-run exocytosis. Such selectivity may arise from molecular size filtering by the fusion pore, however differential intra-WPB cargo re-mobilisation ...
Knipe, Laura, Tom Carter (196826), Carter, T, Laura Knipe (196817), Hannah, MJ, Kiskin, Nikolai I, Kiskin, NI, Nikolai I Kiskin, Matthew J. Hannah (196824), Matthew J Hannah, Babich, Victor, Nikolai I. Kiskin (631240), Victor Babich, Knipe, L, Tom Carter, Victor Babich (631241), Laura Knipe, Carter, Tom, Babich, V, Hannah, Matthew J   +19 more
core   +1 more source

Diagnosis and Management of Polycythemia Vera Complicated by Cerebral Infarction and Subdural Hematoma: A Case Report

iLABMED, EarlyView.
A 70‐year‐old man with recurrent cerebral infarctions, a subdural hematoma, and atherosclerotic disease involving multiple extracranial vascular territories was subsequently diagnosed with polycythemia vera (PV). In patients with recurrent cerebrovascular events accompanied by otherwise unexplained persistent erythrocytosis, JAK2 mutation testing and ...
Hui Zhao, Jie Feng, Yu Jing, Wei Xie, Yingjiao Sha, Yanhong Gao   +5 more
wiley   +1 more source

Study on the mechanism of bleeding in acquired von Willebrand syndrome [PDF]

, 1997
P(論文)The mechanism of bleeding in acquired von Willebrand syndrome (a-vWS), which is associated with several kinds of disorders, is not established. This report investigated the pathogenesis of a-vWS associated with essential thrombocythemia (ET) and ...
河野, 通史, 小池, 隆夫, 安河内, 太郎, 36936, 36937, 36938, 36939, 25285, 垂水, 隆志, 家子, 正裕, 36940, 36941, 沢田, 賢一, 能登谷, 京   +13 more
core  

Third Åland islands conference on von Willebrand disease, 26-28 September 2012: meeting report.

, 2013
The first meeting of international specialists in the field of von Willebrand disease (VWD) was held in the Åland islands in 1998 where Erik von Willebrand had first observed a bleeding disorder in some members of a family from Föglö and a summary of the
M. Makris, Petrini, Alexander, Lee, C, D. Lillicrap, O'Donnell, J S, C. Kannicht, Makris, M, James, Peter,, Budde, U, Berntorp, Erik, Lillicrap, D, Morfini, M, E. Berntorp, Jiménez-Yuste, V, S. Austin, Flood, V, James, Peter, Fuchs, B, Austin, S, M. Morfini, P. Petrini, Petrini, Alexander,, Montgomery, R, Federici, A B, R. Montgomery, B. Fuchs, A.B. Federici, Berntorp, Erik,, Kannicht, C, V. Flood, P. James, C. Lee, Lund University., U. Budde, V. Jiménez Yuste, J. S. O'Donnell   +35 more
core   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

A real‐world analysis of AI chatbot performance for medicines information enquiries

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background The provision of medicines information (MI) services requires interpretation and clinical judgement of complex scenarios by pharmacists. To date, few studies have assessed the performance of artificial intelligence (AI) chatbots to assist pharmacists providing MI advice.
Duncan Yorkston, Tracey Borrie, Paul Chin   +2 more
wiley   +1 more source

A Case of Distal Hereditary Motor Neuronopathy‐7 With Two Novel VWA1 Variants in Compound Heterozygosity

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT Distal hereditary motor neuronopathy‐7 (HMNR7) is an autosomal recessive VWA1‐related disorder characterized predominantly by distal motor involvement. A 41‐year‐old man with a history of childhood orthopedic surgery for foot deformities exhibited progressive distal weakness and muscle atrophy with lower limb predominance. Electrophysiological
Toshiyuki Kakumoto, Kenta Orimo, Takashi Matsukawa, Jun Mitsui, Shoji Tsuji   +4 more
wiley   +1 more source

von Willebrand Factor Propeptide: A Potential Disease Biomarker Not Affected by ABO Blood Groups

, 2015
Epidemiological studies have shown that vascular-related disorders are associated with high von Willebrand factor antigen (VWF:Ag) and VWF propeptide (VWFpp).
C.H. Che Maraina, Mahat Marianor, Abdullah Wan Zaidah   +2 more
core   +1 more source

Q1311X: a novel nonsense mutation of putative ancient origin in the von Willebrand factor gene [PDF]

, 2000
[EN] Type 3 von Willebrand disease, a recessive autosomally inherited bleeding disorder, refers to complete deficiency of von Willebrand factor (VWF).
Haya, Saturnino, Aznar, José A., Casaña, Pilar, Martínez, Francisco, Espinós-Armero, Carmen Ángeles, Lorenzo, José Ignacio   +5 more
core   +1 more source

Mesenchymal stem cells as cellular factories for targeted P2X7 blockade after traumatic brain injury

Neuroprotection, EarlyView.
This manuscript presents a novel therapeutic strategy using mesenchymal stem cells (MSCs) engineered as living drug factories to deliver a P2X7‐blocking nanobody for treatment of ischemic stroke. By combining targeted cellular delivery with sustained local immunomodulation, the approach aims to overcome key limitations of systemic biologic ...
Lucia Fadon‐Padilla, Chengyan Chu, Lorissa McDougall, Yajie Liang, Chinmoy Sarkar, Marta Lipinski, Tim Magnus, Miroslaw Janowski, Piotr Walczak   +8 more
wiley   +1 more source