Mechanochemistry of von Willebrand factor [PDF]
Biomolecular Concepts, 2019 Von Willebrand factor (VWF), a blood multimeric protein with a very high molecular weight, plays a crucial role in the primary haemostasis, the physiological process characterized by the adhesion of blood platelets to the injured vessel wall ...
Lancellotti Stefano +3 more
doaj +6 more sources
Macrophage scavenger receptor SR-AI contributes to the clearance of von Willebrand factor
Haematologica, 2018 Previously, we found that LDL-receptor related protein-1 on macrophages mediated shear stress-dependent clearance of von Willebrand factor. In control experiments, however, we observed that von Willebrand factor also binds to macrophages independently of
Nikolett Wohner +9 more
doaj +2 more sources
Haematologica, 2016 It has been proposed that von Willebrand factor might affect factor VIII immunogenicity by reducing factor VIII uptake by antigen presenting cells. Here we investigate the interaction of recombinant von Willebrand factor with immature monocyte-derived ...
Nicoletta Sorvillo +8 more
doaj +2 more sources
von Willebrand Factor (VWF) Inhibitors in Two Brothers with von Willebrand Disease: A Case Report [PDF]
TH OpenThe development of inhibitors to von Willebrand factor (VWF) is a rare but potentially serious complication of VWF replacement therapy in patients with von Willebrand disease (VWD).
Claudia Djambas Khayat +4 more
doaj +2 more sources
Homocisteína plasmática total e fator von Willebrand no diabete melito experimental Total plasmatic homocysteine and von Willebrand factor in experimental diabetes mellitus [PDF]
Arquivos Brasileiros de Cardiologia, 2007 OBJETIVOS: Determinar os valores plasmáticos de homocisteína e fator von Willebrand, como marcador de disfunção endotelial, em ratos com diabete melito induzido por estreptozotocina.
Renato Delascio Lopes +4 more
doaj +3 more sources
von Willebrand Factor Multimer Formation Contributes to Immunothrombosis in Coronavirus Disease 2019
Critical Care Medicine, 2021 Supplemental Digital Content is available in the text. OBJECTIVES: Prevention and therapy of immunothrombosis remain crucial challenges in the management of coronavirus disease 2019, since the underlying mechanisms are incompletely understood.
A. Doevelaar +14 more
semanticscholar +1 more source
A novel approach to laboratory assessment and reporting of platelet von Willebrand factor
Platelets, 2022 The interaction of platelets with von Willebrand factor is essential for primary hemostasis. Concentration and activity of plasma von Willebrand factor are routine parameters in the assessment of hemostasis disorders. In addition to plasma von Willebrand
Thorsten Kragh +4 more
doaj +1 more source
The relationship between ABO blood group, von Willebrand factor and primary hemostasis.
Blood, 2020 Numerous studies have reported significant associations between ABO blood group and risk for cardiovascular disease. These studies have consistently demonstrated that thrombotic risk is significantly reduced in blood group O individuals.
Soracha E. Ward +2 more
semanticscholar +1 more source
Von Willebrand factor and cancer; metastasis and coagulopathies
Journal of Thrombosis and Haemostasis, 2020 Von Willebrand factor (VWF) is a multimeric procoagulant plasma glycoprotein that mediates platelet adhesion along the endothelium. In addition to its role maintaining normal hemostasis, more recently novel biological functions for VWF have been ...
S. Patmore, S. Dhami, J. O’Sullivan
semanticscholar +1 more source