Results 1 to 10 of about 212,775 (379)
Mechanochemistry of von Willebrand factor [PDF]
Biomolecular Concepts, 2019 Von Willebrand factor (VWF), a blood multimeric protein with a very high molecular weight, plays a crucial role in the primary haemostasis, the physiological process characterized by the adhesion of blood platelets to the injured vessel wall ...
Lancellotti Stefano +3 more
doaj +6 more sources
von Willebrand factor and inflammation [PDF]
Journal of Thrombosis and Haemostasis, 2017 Von Willebrand factor (VWF) is a plasma glycoprotein best known for its crucial hemostatic role in serving as a molecular bridge linking platelets to subendothelial components following vascular injury. In addition, VWF functions as chaperone for coagulation factor VIII. In pathological settings, VWF is recognized as a risk factor for both arterial and
C. Kawecki, P. Lenting, Cécile V. Denis
semanticscholar +4 more sources
Clinical Medicine, 2020 Editor – Ladikou et al have elegantly shown in their series that levels of factor VIII and von Willebrand factor (VWF) are markedly raised in patients with COVID-19 and that there is a reduced level of ADAMTS13 which may be secondary to depletion of the enzyme through consumption.[1][1 ...
Bhogal, P +6 more
openaire +6 more sources
von Willebrand Factor (VWF) Inhibitors in Two Brothers with von Willebrand Disease: A Case Report [PDF]
TH OpenThe development of inhibitors to von Willebrand factor (VWF) is a rare but potentially serious complication of VWF replacement therapy in patients with von Willebrand disease (VWD).
Claudia Djambas Khayat +4 more
doaj +2 more sources
Macrophage scavenger receptor SR-AI contributes to the clearance of von Willebrand factor
Haematologica, 2018 Previously, we found that LDL-receptor related protein-1 on macrophages mediated shear stress-dependent clearance of von Willebrand factor. In control experiments, however, we observed that von Willebrand factor also binds to macrophages independently of
Nikolett Wohner +9 more
doaj +2 more sources
Haematologica, 2016 It has been proposed that von Willebrand factor might affect factor VIII immunogenicity by reducing factor VIII uptake by antigen presenting cells. Here we investigate the interaction of recombinant von Willebrand factor with immature monocyte-derived ...
Nicoletta Sorvillo +8 more
doaj +2 more sources
HERALD of North-Western State Medical University named after I.I. Mechnikov, 2019 Von Willebrand factor is a multimeric glycoprotein which appears to be one of the most important clotting factors providing an implementation of bleeding stop mechanism.
Ye.V. Chernova
semanticscholar +4 more sources
Factor VIII/von Willebrand factor binding to von Willebrand's disease platelets [PDF]
Blood, 1982 A form of von Willebrand's disease has been described with enhanced ristocetin-induced platelet aggregation and anodal migration of the factor VIII/von Willebrand factor protein (type IIb). We studied two families with this form of von Willebrand's disease and macrothrombocytopenia.
HR Gralnick +3 more
openalex +5 more sources
von Willebrand factor propeptide and the phenotypic classification of von Willebrand disease. [PDF]
Blood, 2015 UNLABELLED The ratios between von Willebrand factor propeptide (VWFpp) or factor VIII activity ( FVIII C) and VWF antigen (VWF:Ag) reflect synthesis, secretion, and clearance of VWF. We aimed to define the pathophysiology of 658 patients with type 1, 2,
Y. Sanders +11 more
semanticscholar +9 more sources
Pre-procedural abnormal von Willebrand factor function predicts clinical outcomes after Transcatheter Aortic Valve Implantation: a prospective cohort study [PDF]
Frontiers in Cardiovascular MedicineBackground and objectivesTranscatheter Aortic Valve Implantation (TAVI) is a minimally invasive intervention for aortic stenosis, which is associated with the potential for major vascular complications and arrhythmias. This study aims to identify primary
Haitham Abu Khadija +13 more
doaj +2 more sources