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Mechanochemistry of von Willebrand factor [PDF]
Biomolecular Concepts, 2019 Von Willebrand factor (VWF), a blood multimeric protein with a very high molecular weight, plays a crucial role in the primary haemostasis, the physiological process characterized by the adhesion of blood platelets to the injured vessel wall ...
Lancellotti Stefano +3 more
doaj +6 more sources
von Willebrand factor and inflammation [PDF]
Journal of Thrombosis and Haemostasis, 2017 Von Willebrand factor (VWF) is a plasma glycoprotein best known for its crucial hemostatic role in serving as a molecular bridge linking platelets to subendothelial components following vascular injury.
C. Kawecki, P. Lenting, Cécile V. Denis
semanticscholar +4 more sources
Macrophage scavenger receptor SR-AI contributes to the clearance of von Willebrand factor
Haematologica, 2018 Previously, we found that LDL-receptor related protein-1 on macrophages mediated shear stress-dependent clearance of von Willebrand factor. In control experiments, however, we observed that von Willebrand factor also binds to macrophages independently of
Nikolett Wohner +9 more
doaj +2 more sources
Haematologica, 2016 It has been proposed that von Willebrand factor might affect factor VIII immunogenicity by reducing factor VIII uptake by antigen presenting cells. Here we investigate the interaction of recombinant von Willebrand factor with immature monocyte-derived ...
Nicoletta Sorvillo +8 more
doaj +2 more sources
Deciphering the triad of endothelial glycocalyx, von Willebrand Factor, and P-selectin in inflammation-induced coagulation [PDF]
Frontiers in Cell and Developmental BiologyThis review examines the endothelial glycocalyx’s role in inflammation and explores its involvement in coagulation. The glycocalyx, composed of proteins and glycosaminoglycans, interacts with von Willebrand Factor and could play a crucial role in ...
Guinevere Ferreira +4 more
doaj +2 more sources
Factor VIII/von Willebrand factor binding to von Willebrand's disease platelets [PDF]
Blood, 1982 A form of von Willebrand's disease has been described with enhanced ristocetin-induced platelet aggregation and anodal migration of the factor VIII/von Willebrand factor protein (type IIb). We studied two families with this form of von Willebrand's disease and macrothrombocytopenia.
HR Gralnick +3 more
openalex +5 more sources
von Willebrand factor propeptide and the phenotypic classification of von Willebrand disease. [PDF]
Blood, 2015 UNLABELLED The ratios between von Willebrand factor propeptide (VWFpp) or factor VIII activity ( FVIII C) and VWF antigen (VWF:Ag) reflect synthesis, secretion, and clearance of VWF. We aimed to define the pathophysiology of 658 patients with type 1, 2,
Y. Sanders +11 more
semanticscholar +9 more sources
Clinical Medicine, 2020 Editor – Ladikou et al have elegantly shown in their series that levels of factor VIII and von Willebrand factor (VWF) are markedly raised in patients with COVID-19 and that there is a reduced level of ADAMTS13 which may be secondary to depletion of the enzyme through consumption.[1][1 ...
Bhogal, P +6 more
openaire +3 more sources
von Willebrand Factor Multimer Formation Contributes to Immunothrombosis in Coronavirus Disease 2019
Critical Care Medicine, 2021 Supplemental Digital Content is available in the text. OBJECTIVES: Prevention and therapy of immunothrombosis remain crucial challenges in the management of coronavirus disease 2019, since the underlying mechanisms are incompletely understood.
A. Doevelaar +14 more
semanticscholar +1 more source