Results 141 to 150 of about 52,208 (254)

Reversible formation of von-Willebrand-factor-platelet aggregates in microvascular blood flow. [PDF]

PNAS Nexus
Topuz A, Hoore M, Gompper G, Fedosov DA.
europepmc   +1 more source

Investigator‐Led Research to Improve the Diagnostic Assessment of Platelet Function Disorders: Reflections on the Challenges and Rewards

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Investigator‐led research and quality improvement initiatives have led to important improvements in the diagnostic assessment of platelet function disorders (PFD). Methods Personal reflections were used to summarize our contributions to knowledge on PFD diagnostic assessment, pathogenesis, and bleeding risks.
Catherine P. M. Hayward
wiley   +1 more source

Flow molecular dynamics simulations reveal mechano-presentation of von Willebrand factor through glycan-modulated autoinhibitory modules. [PDF]

APL Bioeng
Louis NELR, Zhao YC, Ju LA.
europepmc   +1 more source

How I Investigate Borderline Prolonged aPTT: An Integrated Laboratory Approach to Mixing Studies and Factor Analysis

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Borderline prolongation of routine clotting assays—particularly the activated partial thromboplastin time (aPTT)—is a common interpretative challenge in laboratory hematology. These reproducible but mildly prolonged results often lie just beyond the upper reference limit and can trigger unnecessary follow‐up, delays, or misinterpretation ...
Nikolaos Androulakis, Eleni Nioti, Antonios Dilintas, Christina Kalpadakis   +3 more
wiley   +1 more source

von Willebrand Factor fibers formed at pathological high shear provide a scaffold for α-synuclein binding and aggregation. [PDF]

Sci Rep
Rossi JM, Diamond SL.
europepmc   +1 more source

Advanced Molecular Analysis in Hemophilia A in a Single Step: Next Generation Sequencing (NGS) and Copy Number Variation (CNV) Analysis

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Hemophilia A, an X‐linked bleeding disorder caused by pathogenic variants in the F8 gene, requires precise genetic diagnosis for optimal management. Conventional stepwise sequence and copy number variation (CNV) analyses are time‐consuming and may leave some cases unresolved.
Enise Avci Durmusalioglu, Esra Isik, Basak Durmus Ozen, Mehmet Mert Topaloglu, Nihal Karadas, Kaan Kavakli, Melike Sezgin Evim, Tolga Aslan, Erşen Kavak, Adalet Meral Gunes, Funda Tayfun Kupesiz, Alphan Kupesiz, Fahri Sahin, Tahir Atik   +13 more
wiley   +1 more source

Von Willebrand Factor and ADAMTS13 in Relation to Major Adverse Limb Events in Peripheral Artery Disease. [PDF]

Vasc Specialist Int
Agid N, Andrisani P, Khan H, Qadura M, Kretz CA, Bhagirath VC.   +5 more
europepmc   +1 more source

Comparing clinical manifestations, treatment strategies and outcomes of Staphylococcus lugdunensis bacteraemia versus Staphylococcus aureus bacteraemia – a retrospective cohort study

Internal Medicine Journal, EarlyView.
Abstract Background Staphylococcus lugdunensis is a coagulase‐negative Staphylococcus that has been increasingly recognised as a significant pathogen capable of causing invasive infections similar to Staphylococcus aureus. Data comparing the clinical manifestations and outcomes of S. lugdunensis bacteraemia to S. aureus bacteraemia remain limited. This
Gemma Webb, Jasmine Choi, Angela Younes, Emily Schembri, Roy Chean, Stephen Guy   +5 more
wiley   +1 more source

Retrospective analysis of von willebrand factor and microthrombus formation in septic shock: associations with TTP-like syndrome and sepsis-induced coagulopathy. [PDF]

Am J Clin Exp Immunol
Liu Y, Yue J, Huang Q, Wan L, Zhao W, Ren Z, Han C, Zhang B, Li C, Pan L, Zhang H, Zhang J.   +11 more
europepmc   +1 more source

Forgotten Steps in the Coagulation Cascade

Haemophilia, EarlyView.
Quentin Van Thillo, Cedric Hermans
wiley   +1 more source