Results 151 to 160 of about 8,401,904 (201)

Platelet von Willebrand factor: Comparison with plasma von Willebrand factor

Thrombosis Research, 1985
Platelet von Willebrand factor (vWf) was compared to its plasma counterpart. The platelet vWf was different from plasma vWf in that the multimeric organization was different, larger multimers were present, and the ratio of vWf activity to antigen was higher.
H R, Gralnick, S B, Williams, L P, McKeown, D M, Krizek, B C, Shafer, M E, Rick   +5 more
openaire   +2 more sources

Antibodies to von Willebrand factor in von Willebrand disease

1995
The occurrence of an alloantibody directed against von Willebrand factor in a multitransfused patient with severe (type III) von Willebrand disease was first reported in 2 consecutive studies by Sarji et al. (1974) and Stratton et al. (1975). After this, 14 additional cases of alloantibodies were described and reviewed by Mannucci and Mari (1984).
P.M. Mannucci, A.B. Federici
openaire   +3 more sources

von Willebrand factor to the rescue

Blood, 2009
Abstractvon Willebrand factor (VWF) is a large multimeric adhesive glycoprotein with complex roles in thrombosis and hemostasis. Abnormalities in VWF give rise to a variety of bleeding complications, known as von Willebrand disease (VWD), the most common inherited bleeding disorder in humans.
Simon F, De Meyer, Hans, Deckmyn, Karen, Vanhoorelbeke   +2 more
openaire   +2 more sources

Biosynthesis, processing and secretion of von Willebrand factor: biological implications

Best Practice and Research in Clinical Haematology, 2001
von Willebrand factor is a multimeric plasma glycoprotein that is required for normal haemostasis. von Willebrand factor is synthesized by endothelial cells and megakaryocytes, and originates from its precursor pro-von Willebrand factor.
Jan A van Mourik, J A van Mourik
exaly   +1 more source

Platelets and von Willebrand factor

Transfusion and Apheresis Science, 2003
The interaction of platelets with von Willebrand factor (VWF) is crucial in the initiation of any hemostatic or thrombotic process. VWF enables the platelet, via its surface glycoprotein receptors, to adhere to exposed subendothelium and to respond to shear stress in the blood.
Markus, Schmugge, Margaret L, Rand, John, Freedman   +2 more
openaire   +2 more sources

Platelet von Willebrand Factor

Mayo Clinic Proceedings, 1991
von Willebrand factor (vWF) circulates in the blood in two distinct compartments. One, plasma vWF, is synthesized and released from endothelial cells; the second, synthesized by megakaryocytes, circulates in platelets primarily stored in the alpha granules.
H R, Gralnick, S B, Williams, L P, McKeown, L, Magruder, K, Hansmann, M, Vail, R I, Parker   +6 more
openaire   +2 more sources

Von Willebrand Factor and the Endothelium

Mayo Clinic Proceedings, 1991
Endothelial cells are the principal source of plasma and basement membrane von Willebrand factor (vWF). To arrive at its biologically active multimeric form, vWF undergoes a series of intracellular processing steps. The protein is synthesized as a large precursor pro-vWF, which dimerizes in the endoplasmic reticulum through disulfide bonds located in ...
D D, Wagner, R, Bonfanti
openaire   +2 more sources

[Von Willebrand factor and Von Willebrand disease].

Nederlands tijdschrift voor geneeskunde, 2014
Von Willebrand factor (VWF) is a multimeric adhesive protein that binds platelets to exposed subendothelium and carries factor VIII in the circulation. VWD is classified into three major subtypes, distinguished by a quantitative deficiency of VWF (type 1: partial deficiency; type 3: complete deficiency) or qualitative defects of VWF (type 2A, 2B, 2M ...
Paul W M, Verhezen, Erik A M, Beckers, Yvonne M C, Henskens   +2 more
openaire   +1 more source

Von Willebrand factor processing

Hämostaseologie, 2017
SummaryVon Willebrand factor (VWF) is a multimeric glycoprotein essential for primary haemostasis that is produced only in endothelial cells and megakaryocytes. Key to VWF’s function in recruitment of platelets to the site of vascular injury is its multimeric structure.
openaire   +2 more sources

von Willebrand's factor and von Willebrand's disease.

Current opinion in hematology, 1997
von Willebrand's factor is required for platelet adhesion to subendothelium, and for normal factor VIII survival in the circulation. These functions require the assembly of von Willebrand's factor into multimers that exhibit properly regulated binding to platelet glycoprotein lb. Recent studies suggest that the propeptide of von Willebrand's factor may
T, Matsushita, Z, Dong, J E, Sadler
openaire   +1 more source