Results 11 to 20 of about 275,200 (373)
Mechanochemistry of von Willebrand factor [PDF]
Biomolecular Concepts, 2019 Von Willebrand factor (VWF), a blood multimeric protein with a very high molecular weight, plays a crucial role in the primary haemostasis, the physiological process characterized by the adhesion of blood platelets to the injured vessel wall ...
Lancellotti Stefano +3 more
doaj +7 more sources
Clinical Medicine, 2020 Editor – Ladikou et al have elegantly shown in their series that levels of factor VIII and von Willebrand factor (VWF) are markedly raised in patients with COVID-19 and that there is a reduced level of ADAMTS13 which may be secondary to depletion of the enzyme through consumption.[1][1 ...
Bhogal, P +6 more
core +5 more sources
Homocisteína plasmática total e fator von Willebrand no diabete melito experimental Total plasmatic homocysteine and von Willebrand factor in experimental diabetes mellitus [PDF]
Arquivos Brasileiros de Cardiologia, 2007 OBJETIVOS: Determinar os valores plasmáticos de homocisteína e fator von Willebrand, como marcador de disfunção endotelial, em ratos com diabete melito induzido por estreptozotocina.
Renato Delascio Lopes +4 more
doaj +3 more sources
Closing the gap – detection of clinically relevant von Willebrand disease in emergency settings through an improved algorithm based on rotational Thromboelastometry [PDF]
BMC Anesthesiology, 2019 Background Hemorrhage and blood loss are still among the main causes of preventable death. Global hemostatic assays are useful point-of-care test (POCT) devices to rapidly detect cumulative effects of plasma factors and platelets on coagulation ...
H.-G. Topf +5 more
doaj +4 more sources
Von Willebrand factor, angiodysplasia and angiogenesis [PDF]
Mediterranean Journal of Hematology and Infectious Diseases, 2013 The large multimeric glycoprotein Von Willebrand factor (VWF) is best known for its role in haemostasis; however in recent years other functions of VWF have been identified, indicating that this protein is involved in multiple vascular processes.
Laffan, MA, Randi, AM, Starke, RD
core +7 more sources
Deciphering the triad of endothelial glycocalyx, von Willebrand Factor, and P-selectin in inflammation-induced coagulation [PDF]
Frontiers in Cell and Developmental BiologyThis review examines the endothelial glycocalyx’s role in inflammation and explores its involvement in coagulation. The glycocalyx, composed of proteins and glycosaminoglycans, interacts with von Willebrand Factor and could play a crucial role in ...
Guinevere Ferreira +4 more
doaj +2 more sources
A novel approach to laboratory assessment and reporting of platelet von Willebrand factor
Platelets, 2022 The interaction of platelets with von Willebrand factor is essential for primary hemostasis. Concentration and activity of plasma von Willebrand factor are routine parameters in the assessment of hemostasis disorders. In addition to plasma von Willebrand
Thorsten Kragh +4 more
doaj +1 more source
Clearance of von Willebrand factor [PDF]
Thrombosis and Haemostasis, 2008 SummaryThe life cycle of von Willebrand factor (VWF) comprises a number of distinct steps, ranging from the controlled expression of theVWF gene in endothelial cells and megakaryocytes to the removal of VWF from the circulation. The various aspects of VWF clearance have been the objects of intense research in the last few years, stimulated by ...
Denis, Cécile, +3 more
openaire +4 more sources
A continuum model for the unfolding of von Willebrand Factor [PDF]
, 2021 von Willebrand Factor is a mechano-sensitive protein circulating in blood that mediates platelet adhesion to subendothelial collagen and platelet aggregation at high shear rates. Its hemostatic function and thrombogenic effect, as well as susceptibility to enzymatic cleavage, are regulated by a conformational change from a collapsed globular state to a
arxiv +1 more source
Haematologica, 2020 We report a new pathogenic mechanism in von Willebrand disease involving the use of a non-canonical splicing site. The proband, carrying the homozygous c.2269_2270del mutation previously classified as a type 3 mutation, showed severely reduced plasma and
Viviana Daidone +3 more
doaj +1 more source