Results 11 to 20 of about 219,337 (367)

A novel approach to laboratory assessment and reporting of platelet von Willebrand factor

Platelets, 2022
The interaction of platelets with von Willebrand factor is essential for primary hemostasis. Concentration and activity of plasma von Willebrand factor are routine parameters in the assessment of hemostasis disorders. In addition to plasma von Willebrand
Thorsten Kragh, Isabell Pekrul, Helmut W. Ott, Michael Spannagl, Patrick Möhnle   +4 more
doaj   +1 more source

The relationship between ABO blood group, von Willebrand factor and primary hemostasis.

Blood, 2020
Numerous studies have reported significant associations between ABO blood group and risk for cardiovascular disease. These studies have consistently demonstrated that thrombotic risk is significantly reduced in blood group O individuals.
Soracha E. Ward, J. O’Sullivan, J. O’Donnell   +2 more
semanticscholar   +1 more source

Von Willebrand factor and cancer; metastasis and coagulopathies

Journal of Thrombosis and Haemostasis, 2020
Von Willebrand factor (VWF) is a multimeric procoagulant plasma glycoprotein that mediates platelet adhesion along the endothelium. In addition to its role maintaining normal hemostasis, more recently novel biological functions for VWF have been ...
S. Patmore, S. Dhami, J. O’Sullivan
semanticscholar   +1 more source

The ADAMTS13‐von Willebrand factor axis in COVID‐19 patients

Journal of Thrombosis and Haemostasis, 2020
Severe coronavirus disease 2019 (COVID‐19) is characterized by an increased risk of thromboembolic events, with evidence of microthrombosis in the lungs of deceased patients.
I. Mancini, L. Baronciani, A. Artoni, P. Colpani, Marina Biganzoli, G. Cozzi, C. Novembrino, Massimo Boscolo Anzoletti, Valentina de Zan, M. Pagliari, R. Gualtierotti, S. Aliberti, M. Panigada, G. Grasselli, F. Blasi, F. Peyvandi   +15 more
semanticscholar   +1 more source

Zebrafish von Willebrand factor [PDF]

Blood Cells, Molecules, and Diseases, 2010
von Willebrand factor (vWF) is a large protein involved in primary hemostasis. A dysfunction in this protein or an insufficient production of the protein leads to improper platelet adhesion/aggregation, resulting in a bleeding phenotype known as von Willebrand disease (vWD).
Maira, Carrillo, Seongcheol, Kim, Surendra Kumar, Rajpurohit, Vrinda, Kulkarni, Pudur, Jagadeeswaran   +4 more
openaire   +2 more sources

Cryptic non-canonical splice site activation is part of the mechanism that abolishes multimer organization in the c.2269_2270del von Willebrand factor

Haematologica, 2020
We report a new pathogenic mechanism in von Willebrand disease involving the use of a non-canonical splicing site. The proband, carrying the homozygous c.2269_2270del mutation previously classified as a type 3 mutation, showed severely reduced plasma and
Viviana Daidone, Eva Galletta, Luigi De Marco, Alessandra Casonato   +3 more
doaj   +1 more source

Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor. [PDF]

PLoS ONE, 2017
Adhesion of erythrocytes to endothelial cells lining the vascular wall can cause vaso-occlusive events that impair blood flow which in turn may result in ischemia and tissue damage.
Michel W J Smeets, Ruben Bierings, Henriet Meems, Frederik P J Mul, Dirk Geerts, Alexander P J Vlaar, Jan Voorberg, Peter L Hordijk   +7 more
doaj   +1 more source

Evaluation of a new semi-automated Hydragel 11 von Willebrand factor multimers assay kit for routine use [PDF]

Journal of Medical Biochemistry, 2021
Background: Accurate diagnosis and classification of von Willebrand disease (VWD) are essential for optimal management. The von Willebrand factor multimers analysis (VWF:MM) is an integral part of the diagnostic process in the phenotypic classification ...
Pikta Marika, Szanto Timea, Viigimaa Margus, Lejniece Sandra, Balode Dārta, Saks Kadri, Banys Valdas   +6 more
doaj   +1 more source

von Willebrand factor. [PDF]

Journal of Clinical Investigation, 1997
The adhesive protein von Willebrand factor contributes to platelet function by mediating the initiation and progression of thrombus formation at sites of vascular injury. In the last 2 years, there has been considerable progress in explaining the biologic properties of von Willebrand factor.
openaire   +4 more sources

An apparently silent nucleotide substitution (c.7056C>T) in the von Willebrand factor gene is responsible for type 1 von Willebrand disease

Haematologica, 2011
Background Nucleotide variations not changing protein sequences are considered silent mutations; accumulating data suggest that they can, however, be important in human diseases.Design and Methods We report an altered splicing process induced by a silent
Viviana Daidone, Lisa Gallinaro, Maria Grazia Cattini, Elena Pontara, Antonella Bertomoro, Antonio Pagnan, Alessandra Casonato   +6 more
doaj   +1 more source