Results 11 to 20 of about 214,027 (378)
Von Willebrand factor, angiodysplasia and angiogenesis [PDF]
Mediterranean Journal of Hematology and Infectious Diseases, 2013 The large multimeric glycoprotein Von Willebrand factor (VWF) is best known for its role in haemostasis; however in recent years other functions of VWF have been identified, indicating that this protein is involved in multiple vascular processes.
Laffan, MA, Randi, AM, Starke, RD
core +7 more sources
von Willebrand factor and inflammation [PDF]
Journal of Thrombosis and Haemostasis, 2017 Von Willebrand factor (VWF) is a plasma glycoprotein best known for its crucial hemostatic role in serving as a molecular bridge linking platelets to subendothelial components following vascular injury. In addition, VWF functions as chaperone for coagulation factor VIII. In pathological settings, VWF is recognized as a risk factor for both arterial and
C. Kawecki, P. Lenting, Cécile V. Denis
semanticscholar +4 more sources
Clinical Medicine, 2020 Editor – Ladikou et al have elegantly shown in their series that levels of factor VIII and von Willebrand factor (VWF) are markedly raised in patients with COVID-19 and that there is a reduced level of ADAMTS13 which may be secondary to depletion of the enzyme through consumption.[1][1 ...
Bhogal, P +6 more
openaire +3 more sources
The ADAMTS13‐von Willebrand factor axis in COVID‐19 patients
Journal of Thrombosis and Haemostasis, 2020 Severe coronavirus disease 2019 (COVID‐19) is characterized by an increased risk of thromboembolic events, with evidence of microthrombosis in the lungs of deceased patients.
I. Mancini +15 more
semanticscholar +1 more source
Of von Willebrand factor and platelets [PDF]
Cellular and Molecular Life Sciences, 2014 Hemostasis and pathological thrombus formation are dynamic processes that require multiple adhesive receptor-ligand interactions, with blood platelets at the heart of such events. Many studies have contributed to shed light on the importance of von Willebrand factor (VWF) interaction with its platelet receptors, glycoprotein (GP) Ib-IX-V and αIIbβ3 ...
Marijke Bryckaert +7 more
openaire +3 more sources
Haematologica, 2020 We report a new pathogenic mechanism in von Willebrand disease involving the use of a non-canonical splicing site. The proband, carrying the homozygous c.2269_2270del mutation previously classified as a type 3 mutation, showed severely reduced plasma and
Viviana Daidone +3 more
doaj +1 more source
Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor. [PDF]
PLoS ONE, 2017 Adhesion of erythrocytes to endothelial cells lining the vascular wall can cause vaso-occlusive events that impair blood flow which in turn may result in ischemia and tissue damage.
Michel W J Smeets +7 more
doaj +1 more source
Evaluation of a new semi-automated Hydragel 11 von Willebrand factor multimers assay kit for routine use [PDF]
Journal of Medical Biochemistry, 2021 Background: Accurate diagnosis and classification of von Willebrand disease (VWD) are essential for optimal management. The von Willebrand factor multimers analysis (VWF:MM) is an integral part of the diagnostic process in the phenotypic classification ...
Pikta Marika +6 more
doaj +1 more source
Factor VIII/von Willebrand factor binding to von Willebrand's disease platelets [PDF]
Blood, 1982 A form of von Willebrand's disease has been described with enhanced ristocetin-induced platelet aggregation and anodal migration of the factor VIII/von Willebrand factor protein (type IIb). We studied two families with this form of von Willebrand's disease and macrothrombocytopenia.
HR Gralnick +3 more
openalex +5 more sources
Carbohydrate of the Factor VIII/von Willebrand Factor in von Willebrand's Disease [PDF]
Journal of Clinical Investigation, 1979 We have examined the plasma Factor VIII/von Willebrand factor (FVIII/vWF) molecule from 16 patients with von Willebrand's disease, and have found no evidence of a significant decrease of carbohydrate content in 15 of these patients. FVIII/vWF was isolated by preparative counter immunoelectrophoresis directly from plasma using antibody to Factor VIII ...
Theodore S. Zimmerman +2 more
openaire +3 more sources