Results 11 to 20 of about 328,885 (284)
A novel approach to laboratory assessment and reporting of platelet von Willebrand factor
Platelets, 2022 The interaction of platelets with von Willebrand factor is essential for primary hemostasis. Concentration and activity of plasma von Willebrand factor are routine parameters in the assessment of hemostasis disorders. In addition to plasma von Willebrand
Thorsten Kragh +4 more
doaj +1 more source
Clearance of von Willebrand factor [PDF]
Thrombosis and Haemostasis, 2008 SummaryThe life cycle of von Willebrand factor (VWF) comprises a number of distinct steps, ranging from the controlled expression of theVWF gene in endothelial cells and megakaryocytes to the removal of VWF from the circulation. The various aspects of VWF clearance have been the objects of intense research in the last few years, stimulated by ...
Denis, Cécile, +3 more
openaire +4 more sources
The relationship between ABO blood group, von Willebrand factor and primary hemostasis.
Blood, 2020 Numerous studies have reported significant associations between ABO blood group and risk for cardiovascular disease. These studies have consistently demonstrated that thrombotic risk is significantly reduced in blood group O individuals.
Soracha E. Ward +2 more
semanticscholar +1 more source
Von Willebrand factor and cancer; metastasis and coagulopathies
Journal of Thrombosis and Haemostasis, 2020 Von Willebrand factor (VWF) is a multimeric procoagulant plasma glycoprotein that mediates platelet adhesion along the endothelium. In addition to its role maintaining normal hemostasis, more recently novel biological functions for VWF have been ...
S. Patmore, S. Dhami, J. O’Sullivan
semanticscholar +1 more source
The ADAMTS13‐von Willebrand factor axis in COVID‐19 patients
Journal of Thrombosis and Haemostasis, 2020 Severe coronavirus disease 2019 (COVID‐19) is characterized by an increased risk of thromboembolic events, with evidence of microthrombosis in the lungs of deceased patients.
I. Mancini +15 more
semanticscholar +1 more source
A continuum model for the unfolding of von Willebrand Factor [PDF]
, 2021 von Willebrand Factor is a mechano-sensitive protein circulating in blood that mediates platelet adhesion to subendothelial collagen and platelet aggregation at high shear rates. Its hemostatic function and thrombogenic effect, as well as susceptibility to enzymatic cleavage, are regulated by a conformational change from a collapsed globular state to a
arxiv +1 more source
Evaluation of a new semi-automated Hydragel 11 von Willebrand factor multimers assay kit for routine use [PDF]
Journal of Medical Biochemistry, 2021 Background: Accurate diagnosis and classification of von Willebrand disease (VWD) are essential for optimal management. The von Willebrand factor multimers analysis (VWF:MM) is an integral part of the diagnostic process in the phenotypic classification ...
Pikta Marika +6 more
doaj +1 more source
von Willebrand Factor unfolding mediates platelet deposition in a model of high-shear thrombosis [PDF]
, 2022 Thrombosis under high-shear conditions is mediated by the mechanosensitive blood glycoprotein von Willebrand Factor (vWF). vWF unfolds in response to strong flow gradients and facilitates rapid recruitment of platelets in flowing blood. While the thrombogenic effect of vWF is well recognized, its conformational response in complex flows has largely ...
arxiv +1 more source
Haematologica, 2020 We report a new pathogenic mechanism in von Willebrand disease involving the use of a non-canonical splicing site. The proband, carrying the homozygous c.2269_2270del mutation previously classified as a type 3 mutation, showed severely reduced plasma and
Viviana Daidone +3 more
doaj +1 more source
Of von Willebrand factor and platelets [PDF]
Cellular and Molecular Life Sciences, 2014 Hemostasis and pathological thrombus formation are dynamic processes that require multiple adhesive receptor-ligand interactions, with blood platelets at the heart of such events. Many studies have contributed to shed light on the importance of von Willebrand factor (VWF) interaction with its platelet receptors, glycoprotein (GP) Ib-IX-V and αIIbβ3 ...
Marijke Bryckaert +7 more
openaire +3 more sources