Results 201 to 210 of about 52,208 (254)
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von Willebrand disease and von Willebrand factor
Haemophilia, 2022AbstractSummaryProgress in both basic and translational research into the molecular mechanisms of VWD can be seen in multiple fields.Genetics of VWDIn the past several decades, knowledge of the underlying pathogenesis of von Willebrand disease (VWD) has increased tremendously, thanks in no small part to detailed genetic mapping of the von Willebrand ...
Brooke, Sadler +2 more
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La Ricerca in Clinica e in Laboratorio, 1990
Von Willebrand factor (vWf) is a multimeric and multivalent adhesive protein which is essential for platelet adhesion to subendothelium and for stabilization of factor VIII procoagulant activity in circulation. The quantitative measurement of vWf involves essentially two different approaches.
F, Rodeghiero, G, Castaman
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Von Willebrand factor (vWf) is a multimeric and multivalent adhesive protein which is essential for platelet adhesion to subendothelium and for stabilization of factor VIII procoagulant activity in circulation. The quantitative measurement of vWf involves essentially two different approaches.
F, Rodeghiero, G, Castaman
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The FASEB Journal, 1993
von Willebrand factor is a multimeric glycoprotein essential for the normal arrest of bleeding after tissue injury (hemostasis). The molecule is present in blood, both in plasma and inside platelets, as well as in endothelial cells and the subendothelial matrix of the vessel wall. Through multiple functional domains, von Willebrand
Z M, Ruggeri, J, Ware
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von Willebrand factor is a multimeric glycoprotein essential for the normal arrest of bleeding after tissue injury (hemostasis). The molecule is present in blood, both in plasma and inside platelets, as well as in endothelial cells and the subendothelial matrix of the vessel wall. Through multiple functional domains, von Willebrand
Z M, Ruggeri, J, Ware
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Von Willebrand factor and thrombosis
Annals of Hematology, 2006There is increasing evidence that von Willebrand factor (VWF), an adhesive multimeric protein that has an important function in primary hemostasis and as a carrier of factor VIII, has a pivotal role in thrombogenesis. In fact, while the presence in plasma of unusually large VWF multimers due to a congenital or acquired deficiency of a VWF-cleaving ...
Franchini M, LIPPI, Giuseppe
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Platelet von Willebrand factor: Comparison with plasma von Willebrand factor
Thrombosis Research, 1985Platelet von Willebrand factor (vWf) was compared to its plasma counterpart. The platelet vWf was different from plasma vWf in that the multimeric organization was different, larger multimers were present, and the ratio of vWf activity to antigen was higher.
H R, Gralnick +5 more
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Antibodies to von Willebrand factor in von Willebrand disease
1995The occurrence of an alloantibody directed against von Willebrand factor in a multitransfused patient with severe (type III) von Willebrand disease was first reported in 2 consecutive studies by Sarji et al. (1974) and Stratton et al. (1975). After this, 14 additional cases of alloantibodies were described and reviewed by Mannucci and Mari (1984).
P.M. Mannucci, A.B. Federici
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Platelets and von Willebrand factor
Transfusion and Apheresis Science, 2003The interaction of platelets with von Willebrand factor (VWF) is crucial in the initiation of any hemostatic or thrombotic process. VWF enables the platelet, via its surface glycoprotein receptors, to adhere to exposed subendothelium and to respond to shear stress in the blood.
Markus, Schmugge +2 more
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Von Willebrand Factor and the Endothelium
Mayo Clinic Proceedings, 1991Endothelial cells are the principal source of plasma and basement membrane von Willebrand factor (vWF). To arrive at its biologically active multimeric form, vWF undergoes a series of intracellular processing steps. The protein is synthesized as a large precursor pro-vWF, which dimerizes in the endoplasmic reticulum through disulfide bonds located in ...
D D, Wagner, R, Bonfanti
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von Willebrand factor to the rescue
Blood, 2009Abstractvon Willebrand factor (VWF) is a large multimeric adhesive glycoprotein with complex roles in thrombosis and hemostasis. Abnormalities in VWF give rise to a variety of bleeding complications, known as von Willebrand disease (VWD), the most common inherited bleeding disorder in humans.
Simon F, De Meyer +2 more
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Platelet von Willebrand Factor
Mayo Clinic Proceedings, 1991von Willebrand factor (vWF) circulates in the blood in two distinct compartments. One, plasma vWF, is synthesized and released from endothelial cells; the second, synthesized by megakaryocytes, circulates in platelets primarily stored in the alpha granules.
H R, Gralnick +6 more
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