Results 21 to 30 of about 209,391 (373)

von Willebrand factor propeptide and the phenotypic classification of von Willebrand disease [PDF]

Blood, 2015
Key Points VWFpp discriminates between type 3 VWD patients and severe type 1 VWD patients with very low VWF levels. The pathophysiological mechanisms of all types of VWD can be defined by the combined ratios of VWFpp/VWF:Ag and FVIII:C/VWF:Ag.
Sanders, Yvonne V., Groeneveld, Dafna, Meijer, Karina, Fijnvandraat, Karin, Cnossen, M. H., Van Der Bom, J. G., Coppens, M., De Meris, Joke, Laros-Van Gorkom, B. A.P., Mauser-Bunschoten, Eveline P., Leebeek, F. W.G., Eikenboom, Jeroen, Fijnvandraat, K., Coppens, M., Kors, A., Zweegman, S., De Meris, J., Goverde, G. J., Jonkers, M. H., Dors, N., Nijziel, M. R., Meijer, K., Tamminga, R. Y.J., Van Der Linden, P. W., Ypma, P. F., Van Der Bom, J. G., Eikenboom, J., Smiers, F. J.W., Granzen, B., Hamulyák, K., Brons, P., Laros-Van Gorkom, B. A.P., Cnossen, M. H., Sanders, Y. V.   +33 more
openaire   +9 more sources

von Willebrand Factor Multimer Formation Contributes to Immunothrombosis in Coronavirus Disease 2019

Critical Care Medicine, 2021
Supplemental Digital Content is available in the text. OBJECTIVES: Prevention and therapy of immunothrombosis remain crucial challenges in the management of coronavirus disease 2019, since the underlying mechanisms are incompletely understood.
A. Doevelaar, M. Bachmann, Bodo Hölzer, F. Seibert, B. Rohn, F. Bauer, O. Witzke, U. Dittmer, Michael Bachmann, S. Yilmaz, R. Dittmer, S. Schneppenheim, N. Babel, U. Budde, T. Westhoff   +14 more
semanticscholar   +1 more source

A novel approach to laboratory assessment and reporting of platelet von Willebrand factor

Platelets, 2022
The interaction of platelets with von Willebrand factor is essential for primary hemostasis. Concentration and activity of plasma von Willebrand factor are routine parameters in the assessment of hemostasis disorders. In addition to plasma von Willebrand
Thorsten Kragh, Isabell Pekrul, Helmut W. Ott, Michael Spannagl, Patrick Möhnle   +4 more
doaj   +1 more source

Clearance of von Willebrand factor [PDF]

Thrombosis and Haemostasis, 2008
SummaryThe life cycle of von Willebrand factor (VWF) comprises a number of distinct steps, ranging from the controlled expression of theVWF gene in endothelial cells and megakaryocytes to the removal of VWF from the circulation. The various aspects of VWF clearance have been the objects of intense research in the last few years, stimulated by ...
Denis, Cécile,, Christophe, Olivier,, Oortwijn, Beatrijs,, Lenting, Peter,   +3 more
openaire   +4 more sources

The relationship between ABO blood group, von Willebrand factor and primary hemostasis.

Blood, 2020
Numerous studies have reported significant associations between ABO blood group and risk for cardiovascular disease. These studies have consistently demonstrated that thrombotic risk is significantly reduced in blood group O individuals.
Soracha E. Ward, J. O’Sullivan, J. O’Donnell   +2 more
semanticscholar   +1 more source

Von Willebrand factor and cancer; metastasis and coagulopathies

Journal of Thrombosis and Haemostasis, 2020
Von Willebrand factor (VWF) is a multimeric procoagulant plasma glycoprotein that mediates platelet adhesion along the endothelium. In addition to its role maintaining normal hemostasis, more recently novel biological functions for VWF have been ...
S. Patmore, S. Dhami, J. O’Sullivan
semanticscholar   +1 more source

The ADAMTS13‐von Willebrand factor axis in COVID‐19 patients

Journal of Thrombosis and Haemostasis, 2020
Severe coronavirus disease 2019 (COVID‐19) is characterized by an increased risk of thromboembolic events, with evidence of microthrombosis in the lungs of deceased patients.
I. Mancini, L. Baronciani, A. Artoni, P. Colpani, Marina Biganzoli, G. Cozzi, C. Novembrino, Massimo Boscolo Anzoletti, Valentina de Zan, M. T. Pagliari, R. Gualtierotti, S. Aliberti, M. Panigada, G. Grasselli, F. Blasi, F. Peyvandi   +15 more
semanticscholar   +1 more source

Of von Willebrand factor and platelets [PDF]

Cellular and Molecular Life Sciences, 2014
Hemostasis and pathological thrombus formation are dynamic processes that require multiple adhesive receptor-ligand interactions, with blood platelets at the heart of such events. Many studies have contributed to shed light on the importance of von Willebrand factor (VWF) interaction with its platelet receptors, glycoprotein (GP) Ib-IX-V and αIIbβ3 ...
Marijke Bryckaert, Marijke Bryckaert, Cécile V. Denis, Cécile V. Denis, Peter J. Lenting, Peter J. Lenting, Jean-Philippe Rosa, Jean-Philippe Rosa   +7 more
openaire   +3 more sources

Cryptic non-canonical splice site activation is part of the mechanism that abolishes multimer organization in the c.2269_2270del von Willebrand factor

Haematologica, 2020
We report a new pathogenic mechanism in von Willebrand disease involving the use of a non-canonical splicing site. The proband, carrying the homozygous c.2269_2270del mutation previously classified as a type 3 mutation, showed severely reduced plasma and
Viviana Daidone, Eva Galletta, Luigi De Marco, Alessandra Casonato   +3 more
doaj   +1 more source

Evaluation of a new semi-automated Hydragel 11 von Willebrand factor multimers assay kit for routine use [PDF]

Journal of Medical Biochemistry, 2021
Background: Accurate diagnosis and classification of von Willebrand disease (VWD) are essential for optimal management. The von Willebrand factor multimers analysis (VWF:MM) is an integral part of the diagnostic process in the phenotypic classification ...
Pikta Marika, Szanto Timea, Viigimaa Margus, Lejniece Sandra, Balode Dārta, Saks Kadri, Banys Valdas   +6 more
doaj   +1 more source